Stephen P.H. Alexander
University of Nottingham
Metabotropic glutamate receptor 4Metabotropic glutamate receptor 2EndocrinologyCannabinoid receptorReceptorChemistryMetabotropic glutamate receptor 1AdenosineAnandamideCannabinoidMetabotropic glutamate receptor 5Endocannabinoid systemBiochemistryMetabotropic glutamate receptor 6Clinical pharmacologyAdenosine receptorMedicineBiologyMetabotropic glutamate receptor 7Pharmacology
Publications 220
BACKGROUND AND PURPOSE The enzyme α/β-hydrolase domain containing 6 (ABHD6), a new member of the endocannabinoid system, is a promising therapeutic target against neuronal-related diseases. However, how ABHD6 activity is regulated is not known. ABHD6 coexists in protein complexes with the brain-specific carnitine palmitoyltransferase 1C (CPT1C). CPT1C is involved in neuro-metabolic functions, depending on brain malonyl-CoA levels. Our aim was to study CPT1C-ABHD6 interaction and determine whethe...
#1Yousra Adel (University of Nottingham)H-Index: 1
#2Stephen P.H. Alexander (University of Nottingham)H-Index: 56
Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain, spinal cord and peripheral nerves. CBD action, on the other hand, is probably mediated through multiple molecular targets.
2 CitationsSource
#2Jonathan K. BallH-Index: 35
Last. Theocharis TsoleridisH-Index: 3
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#1Elliott Lilley (Royal Society)H-Index: 1
#2S. Clare Stanford (UCL: University College London)H-Index: 18
Last. Amrita Ahluwalia (QMUL: Queen Mary University of London)H-Index: 56
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101 CitationsSource
#1Simon D. HardingH-Index: 21
#2Jane F ArmstrongH-Index: 16
Last. Nc-IupharH-Index: 5
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2 CitationsSource
#1Stephen P.H. Alexander (University of Nottingham)H-Index: 56
The use of Cannabis-based preparations for medicinal use has waxed and waned in the multi-millennial history of human co-existence with the plant and its cultivation. Recorded use of preparations f...
3 CitationsSource
#1Stephen P.H. Alexander (University of Nottingham)H-Index: 56
#2Jane F Armstrong (Edin.: University of Edinburgh)H-Index: 16
Last. Michael SpeddingH-Index: 65
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In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targetting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed; an agenda for drug re-purposing, which should allow rapid translation to clinical trials. A simultaneous, multi-pronged approach using conv...
38 CitationsSource
#1Angelo A. Izzo (University of Naples Federico II)H-Index: 73
#2Mauro M. Teixeira (UFMG: Universidade Federal de Minas Gerais)H-Index: 79
Last. Amrita Ahluwalia (QMUL: Queen Mary University of London)H-Index: 56
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Conclusions This editorial illustrates major requirements that authors should con- sider before submitting articles to BJP (see Table 3 for authors' check- list). It also highlights some common shortcomings in natural product pharmacological research, which could be prevented if experiments have appropriate planning and experimental design. BJP is a leading journal in the pharmacological field, in which important new advances are published, and thus, novelty is a major determinant of acceptance ...
40 CitationsSource
#1Stephen P.H. Alexander (University of Nottingham)H-Index: 56
#2Jonathan K. Ball (University of Nottingham)H-Index: 35
Last. Theocharis Tsoleridis (University of Nottingham)H-Index: 3
view all 3 authors...
CoronavirusesCoronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Of the four structural proteins encoded in the viral genome, the RNA winds around the highly basic nucleocapsid (N) protein. The three other structural proteins, envelope (E), membrane (M) and spike (S), are transmembrane proteins. The E protein is a small (9-12 kDa) single transmembrane domain protein, which enables virus assembly with the M protein, a la...
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