Ele Ferrannini
National Research Council
Internal medicineEndocrinologyCardiologyCarbohydrate metabolismIntensive care medicineChemistryType 2 diabetesInsulin resistanceGlucose uptakeGlucose clamp techniqueInsulinBody mass indexHyperinsulinemiaPopulationObesityWeight lossDiabetes mellitusCXCL10MedicineBlood pressureBiology
Publications 450
#1Beatrice CampiH-Index: 4
#2Simone Codini (UniPi: University of Pisa)H-Index: 1
Last. Alessandro Saba (UniPi: University of Pisa)H-Index: 21
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Abstract The present paper describes the development and the validation process – in compliance with the EMA guidelines – of a method based on tandem mass spectrometry coupled to liquid chromatography for the accurate quantification of mannose in human plasma samples. The quick sample preparation procedure, simplified by the absence of any derivatization step, makes the assay suitable for routine use in a clinical chemistry laboratory. The method validation yielded satisfactory selectivity, with...
3 CitationsSource
#1Eleni RebelosH-Index: 11
#2Prince DadsonH-Index: 5
Last. Pirjo NuutilaH-Index: 87
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Objective: Changes of obesity on renal perfusion and metabolism are poorly understood. Our aims were to evaluate whether obesity increases renal regional hemodynamics and metabolism in vivo, and to determine the effects of weight loss. Methods: 23 morbidly obese and 15 age- and sex-matched nonobese controls were recruited. Renal perfusion and fatty acid uptake (FAU) were measured using PET-CT scanning and [15O]- H2O and [18F]fluoro-6-thia-heptadecanoic acid ([18F]THA), respectively. Kidney volum...
#1Elaine ChowH-Index: 11
#2Andrea O.Y. LukH-Index: 25
Last. Juliana C.N. ChanH-Index: 104
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Background: Increased glycemic variability (GV) is thought to represent abnormalities of glucose homeostasis in the progression from prediabetes to diabetes. We evaluated the association between GV, beta-cell function and glucagon-like peptide 1 (GLP-1) response among individuals with prediabetes. Methods: 61 individuals with prediabetes (age Mean±SD 56±9 years, 31 male) each wore a blinded continuous glucose monitor (Medtronic iPro2) for 72 hours. Standard deviation (SD) and coefficient of vari...
#1Yuliya LytvynH-Index: 18
Last. Ele FerranniniH-Index: 110
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Last. Bong Soo ChaH-Index: 57
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Objective: Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance still remains unclear. We investigated the association between spontaneous fasting ketonuria and incident diabetes in conjunction with changes in metabolic parameters in a large population-based, observational study. Research Design and Methods: We analyzed a total of 8,703 individuals free of diabetes at baseline in the Korean Genome and Epidemiology Study, a community-based, ...
#1Gyuri Kim (SMC: Samsung Medical Center)H-Index: 15
#2Sang-Guk Lee (Yonsei University)H-Index: 17
Last. Nam H. Cho (Ajou University)H-Index: 56
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Aims/hypothesis Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance remains unclear. We investigated the association between spontaneous fasting ketonuria and incident diabetes in conjunction with changes in metabolic variables in a large population-based observational study.
4 CitationsSource
#1Thomas DanneH-Index: 55
#2Satish K. Garg (University of Colorado Denver)H-Index: 70
Last. Moshe Phillip (TAU: Tel Aviv University)H-Index: 72
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Sodium–glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mi...
99 CitationsSource
#1Eleni Rebelos (UTU: University of Turku)H-Index: 11
#2Heidi Immonen (UTU: University of Turku)H-Index: 7
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 87
view all 11 authors...
AIMS: To investigate further the finding that insulin enhances brain glucose uptake (BGU) in obese but not in lean people by combining BGU with measures of endogenous glucose production (EGP), and to explore the associations between insulin-stimulated BGU and peripheral markers, such as metabolites and inflammatory markers. MATERIALS AND METHODS: A total of 20 morbidly obese individuals and 12 lean controls were recruited from the larger randomized controlled SLEEVEPASS study. All participants w...
14 CitationsSource
#1Subodh Verma (U of T: University of Toronto)H-Index: 95
#1Subodh Verma (St. Michael's Hospital)H-Index: 26
Last. David Fitchett (St. Michael's Hospital)H-Index: 39
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Molecular and cellular changes in the diabetic heart lead to aberrant myocardial remodeling, characterized by left ventricular hypertrophy (LVH) and eventual diastolic and/or systolic dysfunction (1,2). Although the differential effects of antihypertensive therapy on cardiovascular outcomes in patients with type 2 diabetes and LVH have been studied, those of antihyperglycemic therapy have not (3). In this post hoc analysis of the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabete...
10 CitationsSource