Ele Ferrannini
National Research Council
Internal medicineEndocrinologySurgeryCardiologyCarbohydrate metabolismIntensive care medicineChemistryType 2 diabetesInsulin resistanceGlucose uptakeGlucose clamp techniqueInsulinBody mass indexPancreatic hormoneHyperinsulinemiaPopulationObesityWeight lossDiabetes mellitusCXCL10MedicineBlood pressureBiology
Publications 444
#1Jens-Jacob Lindegaard Lauterlein (OUH: Odense University Hospital)
#2Pernille Hermann (OUH: Odense University Hospital)H-Index: 5
Last. Morten Frost (OUH: Odense University Hospital)H-Index: 24
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Abstract Introduction Sclerostin, an inhibitor of bone formation, has emerged as a potential negative regulator of glucose homeostasis. We aimed to investigate if serum sclerostin associates with insulin sensitivity, beta cell function, prediabetes or metabolic syndrome in healthy men. Materials and Methods Serum sclerostin was measured in basal and insulin-stimulated samples from 526 men without diabetes from the RISC cohort study. An OGTT was performed at baseline and after 3 years. An IVGTT a...
#1Giulia FerranniniH-Index: 5
#2Maria Laura MancaH-Index: 23
Last. Ele FerranniniH-Index: 110
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In the above article, all mentions of “cartilage intermediate-layer protein” refer to “cartilage intermediate-layer protein 2.” The isoform number was misstated in the abstract and one place in the …
#1Eleni Rebelos (UTU: University of Turku)H-Index: 11
#2Marco Bucci (UTU: University of Turku)H-Index: 20
Last. Pirjo Nuutila (UTU: University of Turku)H-Index: 87
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OBJECTIVE Whereas insulin resistance is expressed as reduced glucose uptake in peripheral tissues, the relationship between insulin resistance and brain glucose metabolism remains controversial. Our aim was to examine the association of insulin resistance and brain glucose uptake (BGU) during a euglycemic hyperinsulinemic clamp in a large sample of study participants across a wide range of age and insulin sensitivity. RESEARCH DESIGN AND METHODS [18F]-fluorodeoxyglucose positron emission tomogra...
2 CitationsSource
#1Harshal Deshmukh (Newcastle University)H-Index: 24
#2Anne Lundager Madsen (UCPH: University of Copenhagen)
Last. Mark Walker (Newcastle University)H-Index: 103
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Context Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta cell glucose sensitivity. Objective To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies. Design We performed a geno...
#2Linda E. WatsonH-Index: 25
Last. Andrea NataliH-Index: 61
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The authors wish to correct some minor errors in this article: 1. The fasting insulin secretion rate was correctly shown in Table 1 to be slightly increased after lixisenatide treatment, whereas the text of the Results and Conclusions sections incorrectly reported that it was decreased. 2. Change …
#1Eleonora Grespan (National Research Council)H-Index: 4
#2Toni Giorgino (University of Milan)H-Index: 20
Last. Andrea Mari (National Research Council)H-Index: 67
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Abstract Background and aims. The reduced action of incretin hormones in type 2 diabetes (T2D) is mainly attributed to GIP insensitivity, but efficacy estimates of GIP and GLP-1 differ among studies, and the negligible effects of pharmacological GIP doses remain unexplained. We aimed to characterize incretin action in vivo in subjects with normal glucose tolerance (NGT) or T2D and provide an explanation for the different insulinotropic activity of GIP and GLP-1 in T2D subjects. Methods We used i...
1 CitationsSource
#8Ying WuH-Index: 42
#1Erik J. M. van Bommel (UvA: University of Amsterdam)H-Index: 1
#1Erik J.M. van Bommel (UvA: University of Amsterdam)H-Index: 6
Last. Daniël H. van Raalte (UvA: University of Amsterdam)H-Index: 16
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Sodium-glucose transporter (SGLT)2 inhibitors increase plasma magnesium and plasma phosphate and may cause ketoacidosis, but the contribution of improved glycemic control to these observations as well as effects on other electrolytes and acid-base parameters remain unknown. Therefore, our objective was to compare the effects of SGLT2 inhibitors dapagliflozin and sulfonylurea gliclazide on plasma electrolytes, urinary electrolyte excretion, and acid-base balance in people with Type 2 diabetes (T2...
Inflammation is implicated in the development and severity of the coronavirus disease 2019 (COVID-19), as well as in the pathophysiology of diabetes. Diabetes, especially when uncontrolled, is also recognized as an important risk factor for COVID-19 morbidity and mortality. Furthermore, certain inflammatory markers [i.e. C-reactive protein (CRP), interleukin-6 (IL-6) and ferritin] were reported as strong predictors of worse outcomes in COVID-19 positive patients. The same biomarkers have been as...
9 CitationsSource
#1Maria Laura Manca (UniPi: University of Pisa)H-Index: 23
#2Anna Solini (UniPi: University of Pisa)H-Index: 49
Last. Ele FerranniniH-Index: 14
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Background Chronic kidney disease (CKD) shows different clinical features in Types1 (T1D) and 2 diabetes (T2D). Metabolomics have recently provided useful contribution to the identification of biomarkers of CKD progression in either form of the disease. However, no studies have so far compared plasma metabolomics between T1D and T2D in order to identify differential signatures of progression of estimated glomerular filtration rate (eGFR) decline. Methods We used two large cohorts of T1D (from Fi...
1 CitationsSource