Aharon Levy
Israel Institute for Biological Research
Internal medicineEndocrinologyHippocampal formationPsychologyNeuroscienceCognitionChemistryTransdermalCholinergicAcetylcholineCorticosteroneHippocampusCholinesteraseMuscarinic acetylcholine receptorAnesthesiaMorris water navigation taskMicrodialysisCentral nervous systemMedicineBiologyPharmacology
53Publications
25H-index
1,828Citations
Publications 52
Newest
#1Aharon Levy (Israel Institute for Biological Research)H-Index: 25
#2Giora Cohen (Israel Institute for Biological Research)H-Index: 12
Last. Lily Raveh (Israel Institute for Biological Research)H-Index: 23
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The extrapolation from animal data to therapeutic effects in humans, a basic pharmacological issue, is especially critical in studies aimed to estimate the protective efficacy of drugs against nerve agent poisoning. Such efficacy can only be predicted by extrapolation of data from animal studies to humans. In pretreatment therapy against nerve agents, careful dose determination is even more crucial than in antidotal therapy, since excessive doses may lead to adverse effects or performance decrem...
12 CitationsSource
#1Arik Eisenkraft (UTMB: University of Texas Medical Branch)H-Index: 2
#2Eran Gilat (Israel Institute for Biological Research)H-Index: 14
Last. Aharon Levy (Israel Institute for Biological Research)H-Index: 25
view all 6 authors...
Immediate administration of antidotal treatment is crucial in severe organophosphate (OP) poisoning and the use of an open intravenous (i.v.) line might also be required. The state of casualties might prevent getting access to their veins. The bone injection gun (BIG) was established as a simple method for introducing an intraosseous (i.o.) line and could be applied while wearing a protective suit. The present study followed the pharmacokinetics of the anticonvulsive drug midazolam after i.o. ad...
25 CitationsSource
#1Eugenia Bloch-Shilderman (Israel Institute for Biological Research)H-Index: 6
#2Aharon Levy (Israel Institute for Biological Research)H-Index: 25
Organophosphate (OP) poisoning, which inhibits cholinesterase activity, leads to severe cholinergic symptoms. Effective and quick management of these symptoms is considered critical to the clinical outcome. Acute renal damage following exposure to OP insecticides has been reported. Similar complications might occur following exposure to OP nerve agents, however, this subject has been studied only sporadically. In the present study, the effect of the nerve agent sarin on renal function was examin...
9 CitationsSource
#1Eran Gilat (Israel Institute for Biological Research)H-Index: 14
#2Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
Last. Rachel Brandeis (Israel Institute for Biological Research)H-Index: 23
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Abstract Centrally mediated seizures and convulsions are common consequences of exposure to organophosphates (OPs). These seizures rapidly progress to status epilepticus (SE) and contribute to profound brain injury. Effective management of these seizures is critical for minimization of brain damage. Nasal application of midazolam (1.5 mg/kg) after 5 min of sarin-induced electrographic seizure activity (EGSA) ameliorated EGSA and convulsive behavior (238 ± 90 s). Identical treatment after 30 min ...
45 CitationsSource
#1Amnon GilH-Index: 8
#2Zohar NachumH-Index: 16
Last. Dror TalH-Index: 13
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Introduction: Scopolamine is highly effective for the treatment of seasickness. Nevertheless, transdermal therapeutic system (TTS) scopolamine, despite high compliance on the part of persons treated by the drug, fails to provide protection against seasickness in 26-38% of patients. To the best of our knowledge, the correlation between scopolamine levels in plasma and its therapeutic effect under sailing conditions in the open sea is investigated for the first time in the present study. Methods: ...
13 Citations
#1Eugenia Bloch-Shilderman (Israel Institute for Biological Research)H-Index: 6
#2Tamar KadarH-Index: 26
Last. Eran GilatH-Index: 14
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The protein kinase C (PKC) signaling pathway has been associated with modulation of N -metyl-d-aspartate receptor activity, motor behavior, learning, and memory, all of which are severely impaired in organophosphate (OP) intoxication. Nevertheless, the role of PKC in OP intoxication is largely unknown. The present study attempted to characterize alterations in the immunoreactivity levels of PKC isozymes expressed in different brain areas in the rat following exposure to the nerve agent sarin (1×...
9 CitationsSource
#1Aharon Levy (Israel Institute for Biological Research)H-Index: 25
#2Shira Chapman (Israel Institute for Biological Research)H-Index: 16
Last. Eran Gilat (Israel Institute for Biological Research)H-Index: 14
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The purpose of the present study was to compare the antidotal efficacy and the combined effects on inflammatory markers of three oximes — toxogonine, TMB4 and 2-PAM — in combination with anticholinergic drugs following exposure to sarin vapour by inhalation. Guinea pigs restrained in plethysmographs were exposed to various doses of sarin vapour (in the range of 1.4–4.4ld50). The antidotal mixture was injected immediately (5–20 s) following exposure (3 mg kg−1 atropine and 1 mg kg−1 benactyzine in ...
17 CitationsSource
#1Aharon Levy (Israel Institute for Biological Research)H-Index: 25
#2Moshe Kushnir (Israel Institute for Biological Research)H-Index: 4
Last. Eran Gilat (Israel Institute for Biological Research)H-Index: 14
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The treatment of organophosphate-induced poisoning is based mainly on atropine and an oxime. Prompt anticonvulsive intervention is usually also required to terminate the ensuing seizure activity and to prevent delayed permanent brain damage. Midazolam, a water-soluble benzodiazepine agonist, has the advantage of rapid absorption following intramuscular administration. In mass casualty situations, the availability of an autoinjector, filled with midazolam, might be a further advantage. In the pre...
13 CitationsSource
#1Adina Amir (Israel Institute for Biological Research)H-Index: 16
#2Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
Last. M. RossH-Index: 1
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Sulfur mustard (2,2‐dichlorodiethyl sulfide; HD), is a potent alkylating agent which in liquid or vapor form is capable of causing severe injuries to skin and respiratory tract, and was shown to cause short‐ and long‐term ocular injuries. N‐Acetylcysteine (NAC) may act as a mucolytic agent, changing the “wetting” and scavenging properties of the cornea and thus the adhesion of HD. Moreover, NAC is a scavenger of HD, an antioxidant and a glutathione precursor, which was shown to reduce HD toxicit...
8 CitationsSource
#1Eran Gilat (Israel Institute for Biological Research)H-Index: 14
#2M. Goldman (TAU: Tel Aviv University)H-Index: 2
Last. G. Eshel (TAU: Tel Aviv University)H-Index: 1
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Seizures and status epilepticus, which may contribute to brain injury, are common consequences of exposure to organophosphorus (OP) cholinesterase inhibitors. Effective management of these seizures is critical. To investigate the efficacy of nasal midazolam as an anticonvulsive treatment for OP exposure, as compared to intramuscular midazolam, guinea pigs were connected to a recording swivel for electrocorticograph (ECoG) monitoring and clinical observation. The experimental paradigm consisted o...
21 CitationsSource