Christopher M. Reilly
University of California, Davis
GeneAnatomyOphthalmologyInternal medicinePhenotypeSurgeryPathologyRetrospective cohort studyAdipose tissueChemistryEnucleationImmunologyImmunohistochemistryGoblet cellBreedChemotherapyMetastasisDiseaseLacrimal glandCATSDifferential diagnosisTrabecular meshworkEyelidOcular PathologyRisk factorHistopathologyClinical significanceMedicineMissense mutationBiologyCell biology
57Publications
14H-index
730Citations
Publications 56
Newest
#1Vijay Krishna Raghunathan (UC Davis: University of California, Davis)H-Index: 22
#2Shin Ae Park (UC Davis: University of California, Davis)H-Index: 7
Last. Christopher J. Murphy (UC Davis: University of California, Davis)H-Index: 68
view all 15 authors...
Re-epithelialization of wounds is a critical element of wound closure. Growth factors have been used in combination with conventional wound management to promote closure, but the method of delivery has been limited to the topical application of ointment formulations. Cytoactive factors delivered in this way have short resident times in wounds and have met with limited success. Here, we demonstrate that methods used to covalently immobilize proteins on synthetic materials can be extended to immob...
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#1Kelly E. Knickelbein (UC Davis: University of California, Davis)H-Index: 5
#2Mary E. Lassaline (UC Davis: University of California, Davis)H-Index: 16
Last. Rebecca R. Bellone (UC Davis: University of California, Davis)H-Index: 20
view all 8 authors...
BACKGROUND: Belgian horses are commonly affected with ocular squamous cell carcinoma (SCC), the most common cancer of the equine eye. A missense mutation in damage-specific DNA binding protein 2 (DDB2 c.1013C>T, p.Thr338Met) has been established as a recessive genetic risk factor for ocular SCC in the Haflinger breed. A sample of Belgian horses with unknown SCC phenotype was shown to possess this variant at a similar frequency to the Haflinger breed. Retrospective studies indicate that chestnut ...
6 CitationsSource
#1M. Singer-Berk (UC Davis: University of California, Davis)H-Index: 4
#2Kelly E. Knickelbein (UC Davis: University of California, Davis)H-Index: 5
Last. Rebecca R. Bellone (UC Davis: University of California, Davis)H-Index: 20
view all 14 authors...
Squamous cell carcinoma (SCC) is the most common periocular cancer in horses and the second most common tumor of the horse overall. A missense mutation in damage-specific DNA-binding protein 2 (DDB2, c.1012 C>T, p.Thr338Met) was previously found to be strongly associated with ocular SCC in Haflinger and Belgian horses, explaining 76% of cases across both breeds. To determine if this same variant in DDB2 contributes to risk for ocular SCC in the Arabian, Appaloosa, and Percheron breeds and to det...
5 CitationsSource
#1Bret A. Moore (Veterinary Medical Teaching Hospital)H-Index: 14
#3Brian C. Leonard (UC Davis: University of California, Davis)H-Index: 21
Last. Ala Moshiri (Vision-Sciences, Inc.)H-Index: 14
view all 69 authors...
In the original published version of the article, Valerie Vancollie was mistakenly omitted from the list of members of the International Mouse Phenotyping Consortium. In addition, recognition of funding from Wellcome Trust grant WT098051 was mistakenly omitted from the Acknowledgements.The errors have been corrected in both the PDF and HTML versions of the paper.
1 CitationsSource
#1Jill Covert (UC Davis: University of California, Davis)H-Index: 10
#2Sara M Thomasy (UC Davis: University of California, Davis)H-Index: 24
Last. David J. Maggs (UC Davis: University of California, Davis)H-Index: 28
view all 9 authors...
Abstract Purpose: To assess safety and tolerability of a subconjunctival penciclovir implant in cats infected with feline herpesvirus type 1 (FHV-1). Methods: Subconjunctival blank (n = 4 cats) or ...
1 CitationsSource
#1Rita F WehrmanH-Index: 5
#2Lionel SebbagH-Index: 12
Last. Margaret L MusserH-Index: 4
view all 7 authors...
This report documents the progression of chronic lymphocytic leukemia into diffuse aggressive lymphoma, or Richter’s syndrome, first manifesting as unilateral ophthalmic disease in a 10-year-old coonhound. Following a 1.5-year course of chronic leukemia that was in a clinical remission, the dog was presented for a protruded left globe. Orbital ultrasound revealed a vascular mass located ventromedially and causing indentation of the sclera. Skull computed tomography showed exophthalmos due to a s...
#1Kelly E. Knickelbein (Veterinary Medical Teaching Hospital)H-Index: 5
#2Mallory Stock (Veterinary Medical Teaching Hospital)
Last. Mary E. Lassaline (UC Davis: University of California, Davis)H-Index: 16
view all 5 authors...
: An 18-year-old American Miniature Horse mare was presented with a complaint of a scleral swelling affecting the right eye and a history of suspected trauma 6 weeks prior to evaluation. Clinical findings included severe blepharospasm, a bulbous swelling of the dorsotemporal bulbar conjunctiva, and phthisis bulbi. Ocular ultrasound was recommended but declined. Enucleation was elected for the blind, painful eye and was performed standing. Gross and histopathologic examinations of the globe were ...
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#1Krista A. Keller (Veterinary Medical Teaching Hospital)H-Index: 6
#2David Sanchez-Migallon Guzman (UC Davis: University of California, Davis)H-Index: 31
Last. Richard R. Dubielzig (UW: University of Wisconsin-Madison)H-Index: 39
view all 7 authors...
Abstract This report describes post-traumatic ocular lymphoma in three companion rabbits; 2 rabbits with unilateral disease and one with bilateral disease. Historical findings suggestive of a traumatic event included either external unilateral ocular trauma or bilateral phacoemulsification. Severe corneal changes, presence of an anterior chamber mass(es), low intraocular pressures and ocular discomfort were noted on ophthalmic examinations. All eyes were treated for variable courses with standar...
3 CitationsSource
#1Bret A. Moore (Veterinary Medical Teaching Hospital)H-Index: 14
#2Brian C. Leonard (UC Davis: University of California, Davis)H-Index: 21
Last. Ala Moshiri (UC Davis: University of California, Davis)H-Index: 14
view all 69 authors...
Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for ...
14 CitationsSource
#1M. Singer-Berk (UC Davis: University of California, Davis)H-Index: 4
#2Kelly E. Knickelbein (UC Davis: University of California, Davis)H-Index: 5
Last. Rebecca R. Bellone (UC Davis: University of California, Davis)H-Index: 20
view all 13 authors...
: Squamous cell carcinoma (SCC) is the most common cancer affecting the equine eye, with a higher incidence documented in Haflinger horses. Recently, a missense variant in the gene damage specific DNA binding protein 2 (DDB2, p.Thr338Met) on ECA12 was identified as a risk factor for the development of limbal SCC in Haflinger horses. SCC also occurs on the nictitating membrane; therefore, investigating the role of this missense variant in nictitating membrane SCC is warranted. In this study, a co...
10 CitationsSource