Dongfeng Chen
Guangzhou University of Chinese Medicine
AdductInternal medicineEndocrinologyCellMolecular biologyChemistryApoptosisMesenchymal stem cellHydroxyl radicalAntioxidantMTT assayABTSDPPHStem cellElectrospray ionizationChromatographyBiochemistrySignal transductionStereochemistryMedicineBiologyCell biologyPharmacology
130Publications
22H-index
1,670Citations
Publications 128
Newest
#1Juan Lu (Guangzhou University of Chinese Medicine)H-Index: 2
#2Xuelei Liu (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Meiling Zhu (Guangzhou University of Chinese Medicine)H-Index: 4
view all 13 authors...
The objective of this study was to explore the neuroprotective effect of moxibustion on rats with Parkinson’s disease (PD) and its mechanism. A Parkinson’s disease model was established in rats using a two-point stereotactic 6-hydroxydopamine injection in the right substantia nigra (SN) and ventral tegmental area. The rats received moxibustion at the Baihui (GV20) and Sishencong (EX-HN1) acupoints for 20 minutes, six times a week, for 6 weeks. The right SN tissue was histologically and immunohis...
4 CitationsSource
#1Xican LiH-Index: 19
#2Xiaojian OuyangH-Index: 5
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 4 authors...
The biological process, 3-O-galactosylation, is important in plant cells. To understand the mechanism of the reduction of flavonol antioxidative activity by 3-O-galactosylation, myricetin-3-O-galactoside (M3OGa) and myricetin aglycone were each incubated with 2 mol α,α-diphenyl-β-picrylhydrazyl radical (DPPH•) and subsequently comparatively analyzed for radical adduct formation (RAF) products using ultra-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-fl...
7 CitationsSource
#1Yamei Liu (Guangzhou University of Chinese Medicine)H-Index: 9
#2Wang-Yang Li (Hunan University)H-Index: 1
Last. Wang Bin (GU: Guangzhou University)H-Index: 4
view all 14 authors...
ABSTRACT MSC transplantation has been explored as a new clinical approach to stem cell-based therapies for bone diseases in regenerative medicine due to their osteogenic capability. However, only a small population of implanted MSC could successfully reach the injured areas. Therefore, enhancing MSC migration could be a beneficial strategy to improve the therapeutic potential of cell transplantation. Catharmus tinctorius volatile oil (CTVO) was found to facilitate MSC migration. Further explorat...
2 CitationsSource
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 1
#1Liuchao Hu (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Yiwen Luo (Guangzhou University of Chinese Medicine)H-Index: 5
view all 13 authors...
: Bone fractures are very common, and above 5% of the fractures are impaired, leading to nonunions and severe disablilities. The traditional Chinese medicine Bushen Huoxue decoction (BHD) has been used to treat fracture in China. Our previous report has found that BHD promotes migration of rat mesenchymal stem cells (rMSCs) by activating Wnt5a signaling pathway. However, whether and how miRNAs are involved in modulating rMSCs migration induced by BHD has not been explored. In the present study, ...
2 CitationsSource
#1Xiang-Jun Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Fangfang Xie (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
view all 9 authors...
: Genomic DNA demethylation is important for mammalian embryonic development and organ function. 5-Hydroxymethylcytosine (5hmC) is considered a novel epigenetic marker. Ten-eleven translocation (TET) enzymes convert 5-methylcytosine (5mC) to 5hmC. To explore the dynamic changes of epigenetic modifications during organogenesis in the late mouse fetus, the regional distribution and histological localization of 5hmC and TET enzymes was investigated by immunohistochemical method. The liver of mouse ...
1 CitationsSource
#1Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
#2Xiaojian Ouyang (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 4 authors...
To probe the effect of 3′,8″-dimerization on antioxidant flavonoids, acacetin and its 3′,8″-dimer isoginkgetin were comparatively analyzed using three antioxidant assays, namely, the ·O2− scavenging assay, the Cu2+ reducing assay, and the 2,2′-azino bis(3-ethylbenzothiazolin-6-sulfonic acid) radical scavenging assay. In these assays, acacetin had consistently higher IC50 values than isoginkgetin. Subsequently, the acacetin was incubated with 4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxy radicals...
11 CitationsSource
#1Rongxin Cai (Guangzhou University of Chinese Medicine)H-Index: 3
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 19
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 6 authors...
5 CitationsSource
#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Shanyu Ye (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
: Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were p...
8 CitationsSource
#1Minshi Liang (Guangzhou University of Chinese Medicine)H-Index: 4
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 5 authors...
Echinatin and its 1,1-dimethyl-2-propenyl derivative licochalcone A are two chalcones found in the Chinese herbal medicine Gancao. First, their antioxidant mechanisms were investigated using four sets of colorimetric measurements in this study. Three sets were performed in aqueous solution, namely Cu2+-reduction, Fe3+-reduction, and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•)-scavenging measurements, while 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•)-scavenging colori...
20 CitationsSource
#1Qianru Liu (Guangzhou University of Chinese Medicine)H-Index: 3
#2Xican Li (Guangzhou University of Chinese Medicine)H-Index: 9
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 4 authors...
To explore whether and how glucuronidation affects pyrogallol-type phytophenols, scutellarein and scutellarin (scutellarein-7-O-glucuronide) were comparatively investigated using a set of antioxidant analyses, including spectrophotometric analysis, UV-vis spectra analysis, and ultra-performance liquid chromatography coupled with electrospray ionization-quadrupole time-of-flight tandem mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) analysis. In spectrophotometric analyses of the scavenging of 1,1-diphe...
12 CitationsSource