Catherine A Egan
UCL Institute of Ophthalmology
OphthalmologyOptometrySurgeryPathologyRandomized controlled trialFundus (eye)Macular degenerationRetinaMacular telangiectasiaVisual acuityRetinopathyOptical coherence tomographyDiabetic retinopathyFluorescein angiographyMacular edemaRetinalRanibizumabOptical coherence tomography angiographyDiabetes mellitusMedicine
258Publications
43H-index
5,022Citations
Publications 214
Newest
#1Moawiya Alshunnar (Newcastle University)
#2Roy Schwartz (Moorfields Eye Hospital)H-Index: 5
Last. Usha Chakravarthy ('QUB': Queen's University Belfast)H-Index: 76
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#1Alexander Tanner (UCL Institute of Ophthalmology)H-Index: 1
#2Hwei Wuen Chan (Moorfields Eye Hospital)H-Index: 8
Last. Omar A. Mahroo (UCL Institute of Ophthalmology)H-Index: 17
view all 17 authors...
1 CitationsSource
#1Peter MalocaH-Index: 10
#2Emily A. Williams (University of Leeds)
Last. Philippe C. CattinH-Index: 27
view all 16 authors...
Purpose Virtual reality (VR) can be useful in explaining diseases and complications that affect children in order to improve medical communications with this vulnerable patient group. So far, children and young people's responses to high-end medical VR environments have never been assessed. Methods An unprecedented number of 320 children and young people were given the opportunity to interact with a VR application displaying original ophthalmic volume data via a commercially available tethered h...
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#1Parmita Mehta (UW: University of Washington)H-Index: 3
#2Christine A. Petersen (UW: University of Washington)H-Index: 1
Last. Ariel Rokem (UW: University of Washington)H-Index: 27
view all 11 authors...
Purpose To develop a multi-modal model to automate glaucoma detection. Design Development of a machine-learning glaucoma detection model. Methods We selected a study cohort from the UK Biobank dataset with 1193 eyes of 863 healthy subjects and 1283 eyes of 771 subjects with glaucoma. We trained a multi-modal model that combines multiple deep neural nets, trained on macular optical coherence tomography volumes and color fundus photos, with demographic and clinical data. We performed an interpreta...
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#1Roy Schwartz (UCL: University College London)H-Index: 5
#2Alasdair Warwick (UCL: University College London)H-Index: 2
Last. Adnan Tufail (UCL: University College London)H-Index: 55
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Abstract Purpose Management of neovascular age-related macular degeneration (nAMD) has evolved over the last decade with several treatment regimens and different medications. This study describes the treatment patterns and, importantly, visual outcomes over ten years in a large cohort of patients. Design Retrospective analysis of electronic health records from 27 National Health Service (NHS) secondary care healthcare providers in the UK. Participants Treatment-naive patients receiving at least ...
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#1Roberto Bonelli (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 6
#2Victoria E. Jackson (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 15
Last. Melanie Bahlo (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 61
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#1Richard GaleH-Index: 17
#2Maria Pikoula (UCL: University College London)H-Index: 4
Last. Paul Taylor (UCL: University College London)H-Index: 27
view all 7 authors...
Background/aims Clinical trials suggest anti-vascular endothelial growth factor is more effective than intravitreal dexamethasone as treatment for macular oedema secondary to branch retinal vein occlusion. This study asks if ‘real world’ data from a larger and more diverse population, followed for a longer period, also support this conclusion. Methods Data collected to support routine care at 27 NHS (National Health Service) Trusts between February 2002 and September 2017 contained 5661 treatmen...
3 CitationsSource
#1Laurenz Pauleikhoff (University of Oxford)
#1Laurenz Pauleikhoff (University of Freiburg)
Last. Peter Charbel Issa (University of Oxford)H-Index: 44
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PURPOSE To investigate the role of fundus autofluorescence (FAF) imaging in the diagnosis of macular telangiectasia type 2 (MacTel) and to describe disease-associated FAF patterns and their origin. DESIGN Cross-sectional multicenter study Methods: FAF images were collected from the multicentre MacTel Natural History Observation and Registry Study. In a first qualitative approach, common FAF phenotypes were defined and correlated with multimodal imaging. We then evaluated how many eyes showed FAF...
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#1Roberto Bonelli (University of Melbourne)H-Index: 6
#2Victoria E. Jackson (University of Melbourne)H-Index: 15
Last. Catherine A Egan (Moorfields Eye Hospital)H-Index: 43
view all 13 authors...
Macular Telangiectasia Type 2 (MacTel) is a rare degenerative retinal disease with complex genetic architecture. We performed a genome-wide association study on 1,067 MacTel patients and 3,799 controls, which identified eight novel genome-wide significant loci (p < 5 × 10-8), and confirmed all three previously reported loci. Using MAGMA, eQTL and transcriptome-wide association analysis, we prioritised 48 genes implicated in serine-glycine biosynthesis, metabolite transport, and retinal vasculatu...
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#1Darren S. Thomas (UCL: University College London)H-Index: 2
#2Aaron Y. Lee (UW: University of Washington)H-Index: 26
Last. Adnan Tufail (UCL: University College London)H-Index: 6
view all 11 authors...
One-in-four ophthalmology trials are single-armed, which poses challenges to their interpretation. We demonstrate how real-world cohorts used as external/synthetic control arms can contextualise such trials. We herein emulated a target trial on the intention-to-treat efficacy of off-label bevacizumab (q6w) pro re nata relative to fixed-interval aflibercept (q8w) for improving week-54 visual acuity of eyes affected by neovascular age-related macular degeneration. The bevacizumab arm (n 65) was ta...
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