Takashi Wada
Kanazawa University
Internal medicineUrologyChemokineEndocrinologyPathologyRenal functionImmunologyKidney diseaseProteinuriaDiabetic nephropathyKidneyGlomerulonephritisFibrosisPathogenesisNephropathyNephrologyDiabetes mellitusMedicineBiologyGastroenterology
Publications 365
#1Takashi Wada (Kanazawa University)H-Index: 61
#2Kazumi Mori-Anai (Mitsubishi Tanabe Pharma)
Last. Meg Jardine (The George Institute for Global Health)H-Index: 43
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AIM The sodium-glucose cotransporter 2 inhibitor canagliflozin reduced kidney failure and cardiovascular events in the Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial. We conducted a post-hoc analysis to evaluate the efficacy and safety of canagliflozin in a subgroup of participants in East and Southeast Asian (EA) countries who are at high risk of renal complications. METHODS Participants with an estimated glomerular filtration rate o...
#1Eri MusoH-Index: 32
#2Soichi SakaiH-Index: 3
Last. Yukio Yuzawa (Fujita Health University)H-Index: 55
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Many reports have shown the therapeutic efficacy of LDL apheresis (LDL-A) in drug-resistant nephrotic syndrome (NS) for improvement of heavy proteinuria and severely impaired renal function. To obtain comprehensive results in a large number of cases, a post-hoc analysis of the POLARIS study was performed by stratifying enrolled cases according to pretreatment eGFR levels indicating normal (N) (≥60 mL/min/1.73m2 ), moderately impaired (M) (≥30 to <60 mL/min/1.73m2 ), and severely impaired (S) (<3...
#1Sadayoshi Ito (Tohoku University)H-Index: 90
#2Naoki Kashihara (Kawasaki Medical School)H-Index: 43
Last. Tomoko Sawanobori (Daiichi Sankyo)H-Index: 2
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BACKGROUND Esaxerenone has potential renoprotective effects and reduces the urinary albumin-to-creatinine ratio (UACR) in patients with diabetic kidney disease and overt nephropathy. We investigated the efficacy and safety of esaxerenone in Japanese patients with type 2 diabetes (T2D) and macroalbuminuria (UACR ≥ 300 mg/g creatinine). METHODS We conducted a multicenter, single-arm, open-label phase III study in 56 patients with T2D and UACR ≥ 300 mg/g creatinine with estimated glomerular filtrat...
Abstract null null Adipose tissue-derived stem cells (ADSCs) have been suggested as a novel treatment for non-alcoholic steatohepatitis (NASH); however, the mechanisms underlying their therapeutic effect remain poorly understood. In this study, we aimed to investigate the association of Notch signaling, which is crucial for cellular proliferation and differentiation in ADSC-mediated treatment of NASH. Flow cytometry analysis of ADSCs showed that they expressed the Notch ligands JAG1, DLL1, and D...
#1Megumi Oshima (Kanazawa University)H-Index: 7
#2Tadashi Toyama (Kanazawa University)H-Index: 23
Last. Tetsuya BabazonoH-Index: 30
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Introduction null Changes in albuminuria or estimated glomerular filtration rate (eGFR) can be used as a surrogate endpoint of end-stage kidney disease (ESKD) in people with type 2 diabetes. We investigated whether the combined changes in albuminuria and eGFR are more strongly associated with future risk of ESKD. null Research design and methods null Using data from a multicenter observational cohort study of people with type 2 diabetes, we evaluated the association of percentage change in urine...
#1Yasunori Iwata (Kanazawa University)H-Index: 27
#2Norihiko Sakai (Kanazawa University)H-Index: 29
Last. Takashi Wada (Kanazawa University)H-Index: 61
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INTRODUCTION The number of patients with end stage kidney disease (ESKD) are increasing world-side. While interstitial fibrosis (IF) is a common step for the progression to ESKD, therapeutic options for IF is still limited in clinical settings. We have reported that bone marrow-derived fibrotic cell, fibrocyte, is involved in the pathogenesis of kidney fibrosis. Also recent studies revealed that erythropoietin has protective effect on kidney diseases. However, it is unknown whether erythropoieti...
#1Masayuki YamanouchiH-Index: 17
#2Kengo Furuichi (Kanazawa Medical University)H-Index: 6
Last. Takashi Wada (Kanazawa University)H-Index: 61
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BACKGROUND Prognosticating disease progression in patients with diabetic kidney disease (DKD) is challenging, especially in the early stages of kidney disease. Anemia can occur in the early stages of kidney disease in diabetes. We therefore postulated that serum hemoglobin concentration, as a reflection of incipient renal tubulointerstitial impairment, can be used as a marker to predict DKD progression. METHODS Drawing on nationally representative data of patients with biopsy-proven DKD, 246 pat...
#1Taku Kobayashi (Kanazawa University)
#2Yasunori Iwata (Kanazawa University)H-Index: 27
Last. Takashi Wada (Kanazawa University)H-Index: 61
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Recent studies have revealed that the gut microbiota plays a crucial role in maintaining a healthy, as well as diseased condition. Various organs and systems, including the kidney, are affected by the gut microbiota. While the impacts of the gut microbiota have been reported mainly on chronic kidney disease, acute kidney injury (AKI) is also affected by the intestinal environment. In this review, we discussed the pathogenesis of AKI, highlighting the relation to the gut microbiota. Since there i...
#1Yoshio Sakai (Kanazawa University)H-Index: 29
#2Shinya Fukunishi (Osaka Medical College)H-Index: 15
Last. Shuichi Kaneko (Kanazawa University)H-Index: 104
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Abstract Introduction Liver cirrhosis is the ultimate condition of chronic liver diseases. Non-alcoholic steatohepatitis and fatty liver diseases are emerging in association with metabolic syndrome largely due to excess nutrition. Stromal cells of adipose tissue are enriched mesenchymal stem cells which are pluripotent and immunomodulatory, which are expected to be applied for repairing/regenerative therapy of the impaired organs. Methods We conducted the multi-institutional clinical trial (Japa...
#1Taro Miyagawa (Kanazawa University)H-Index: 3
#2Yasunori Iwata (Kanazawa University)H-Index: 27
Last. Takashi Wada (Kanazawa University)H-Index: 61
view all 15 authors...
We present the case of a 67-year-old man in good health with perirenal hematoma due to a ruptured arterial aneurysm in the kidney. The patient developed weight loss, muscle weakness, multiple mononeuropathy, hypertension, anemia, renal insufficiency, and multiple lacuna infarctions about a month ago. He was admitted to the hospital due to worsening of his symptom. After admission, severe right-flank pain suddenly occurred; he was then transferred to our hospital. Renal angiography revealed bilat...