Andrew L. Mason
University of Alberta
Internal medicineSurgeryPathologyVirologyImmunologyVirusLiver diseaseAutoimmune hepatitisCirrhosisDiseaseLiver transplantationPrimary biliary cirrhosisBetaretrovirusPrimary sclerosing cholangitisUrsodeoxycholic acidTransplantationIn patientMedicineBiologyGastroenterology
Publications 264
#1Alessio Gerussi (University of Milano-Bicocca)H-Index: 7
#1Alessio Gerussi (University of Milano-Bicocca)H-Index: 2
Last. Marco Carbone (University of Milano-Bicocca)H-Index: 26
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Abstract Background and Aims Gamma-glutamyltransferase (GGT) is a serum marker of cholestasis. We investigated whether serum level of GGT is a prognostic marker for patients with primary biliary cholangitis (PBC). Methods We analyzed data from patients with PBC from the Global PBC Study Group, comprising 14 centers in Europe and North America. We obtained measurements of serum GGT at baseline and time points after treatment. We used Cox model hazard ratios to evaluate the association between GGT...
3 CitationsSource
Autoimmune liver disease (AILD) spans a spectrum of chronic disorders affecting the liver parenchyma and biliary system. Three main categories of AILD are autoimmune hepatitis (AIH), primary biliar...
#1Rosanna Asselta (Humanitas University)H-Index: 39
#2Elvezia Maria Paraboschi (Humanitas University)H-Index: 16
Last. Pietro Invernizzi (University of Milano-Bicocca)H-Index: 80
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ABSTRACT Background & aims Genome-wide association studies (GWAS) in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually-dimorphic complex autoimmune disease. Methods We performed a chrX-wide association study (XWAS), including genotype data from five GWAS (from Italy, UK, Canada, China, Japan; 5,244 cases, 11,875 controls). Results Single-marker association analyses...
1 CitationsSource
#1Heather J. Cordell (Newcastle University)H-Index: 76
#2James J. Fryett (Newcastle University)H-Index: 2
Last. George F. Mells (University of Cambridge)H-Index: 23
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Abstract BACKGROUND & AIMS Primary biliary cholangitis (PBC) is a chronic liver disease in which autoimmune destruction of the small intra-hepatic bile ducts eventually leads to cirrhosis. Many patients have inadequate response to licensed medications, motivating the search for novel therapies. Previous genome-wide association studies (GWAS) and meta-analyses (GWMA) of PBC have identified numerous risk loci for this condition, providing insight into its aetiology. We undertook the largest GWMA o...
1 CitationsSource
#1Ellina Lytvyak (U of A: University of Alberta)H-Index: 7
#2Mina Niazi (U of A: University of Alberta)
Last. Andrew L. Mason (U of A: University of Alberta)H-Index: 54
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Recurrent primary biliary cholangitis (rPBC) is frequent following liver transplantation and associated with increased morbidity and mortality. It has been argued that rPBC behaves like an infectious disease because more potent immunosuppression with tacrolimus is associated with earlier and more severe recurrence. Prophylactic ursodeoxycholic acid is an established therapeutic option to prevent rPBC, whereas the role of second line therapies, such as obeticholic acid and bezafibrate in rPBC rem...
#1L. NguyenH-Index: 1
#1Linh NguyenH-Index: 9
Last. John S. KlassenH-Index: 44
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Emerging evidence suggests that host glycans influence infection by SARS-CoV-2. Here, we reveal that the receptor-binding domain (RBD) of the spike (S)-protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (SA), with preference for the oligosaccharide of monosialylated gangliosides. Gangliosides embedded within an artificial membrane also bind the RBD. The monomeric affinities (Kd = 100-200 M) of gangliosides for the RBD are similar to heparan sulfate, another negatively charg...
4 CitationsSource
Background Opportunity to redefine the care journeys for those living with primary biliary cholangitis (PBC) includes facilitating access to enhanced (PBC-dedicated) programmes by nonspecialist risk 'flagging' of patients. Objective To develop a nonexpert PBC stratification tool to help care pathway choices (standard vs. enhanced) choices in PBC. Methods We included ursodeoxycholic acid-treated patients with PBC from the Global PBC Study Group. The performance of baseline and 1-year clinical mar...
1 CitationsSource
#1Guangzhi Zhang (U of A: University of Alberta)H-Index: 3
#2Kiandokht Bashiri (U of A: University of Alberta)H-Index: 1
Last. Andrew L. Mason (U of A: University of Alberta)H-Index: 54
view all 8 authors...