Jude Ogechukwu Okoye
Nnamdi Azikiwe University
CancerInternal medicinePathologyOncologymicroRNAAscusVirologyAntibodyChemistryImmunologyVirusCholesterolHPV infectionLesionHerpes simplex virusEpstein–Barr virusPopulationChinchilla rabbitHuman immunodeficiency virus (HIV)Incidence (epidemiology)Breast cancerTraditional medicineHistologyPapanicolaou stainMedicineStainingBiologyGastroenterologyPharmacology
34Publications
5H-index
37Citations
Publications 38
Newest
#1Jude Ogechukwu Okoye (Nnamdi Azikiwe University)H-Index: 5
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#1Damilohun Samuel Metibemu (FUNAAB: Federal University of Agriculture, Abeokuta)H-Index: 6
#2Oluseyi Adeboye Akinloye (FUNAAB: Federal University of Agriculture, Abeokuta)H-Index: 10
Last. Idowu Olaposi Omotuyi (Adekunle Ajasin University)H-Index: 2
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Objectives null Inhibition of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, the rate rate-determining enzyme for the biogenesis of cholesterol is known to show antineoplastic effects. Therefore, this study investigates the in-silico HMG-CoA reductase (HMGCR)-inhibitory and in-vivo anti-lipidaemic/anticancer effects of carotenoids from Spondias mombin. null Methods null Carotenoids from S. mombin leaves were characterized with the aid of liquid chromatography-electrospray ionization-...
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#1Jude Ogechukwu Okoye (Nnamdi Azikiwe University)H-Index: 5
Last. Anthony Ajuluchukwu Ngokere (Nnamdi Azikiwe University)H-Index: 3
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BACKGROUND/OBJECTIVE Cervical Cancer is the 6th most common and 3rd most deadly cancer among women. Despite the fact that the majority of the countries in Asia and Africa have a similar economy and low life expectancy, the mean age-standardized incidence rate (ASIR) of cervical cancer is substantially higher in Africa than in Asia. This study identified the correlates of the higher ASIR rates in Africa relative to Asia against two timelines; 2004-2009 and 2010-2017. METHODS Peer-reviewed article...
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#1Jude Ogechukwu Okoye (Nnamdi Azikiwe University)H-Index: 5
#2Chukwudi Amaechi Ofodile (Nnamdi Azikiwe University)H-Index: 1
Last. Okechi O. Obioma (Abia State University)H-Index: 1
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This review assessed the rate of high-risk Human papillomavirus (HPV) infection among women living in sub-Saharan Africa. It also determined the prevalence of high-risk HPV (hrHPV) among human immunodeficiency virus seropositive (HIV+) and seronegative (HIV-) women in sub-Saharan Africa, pre-and post-year 2010. In this systematic review, Google Scholar, PubMed Central, and EMBASE databases were searched to identify cohort and case-controlled studies that investigated the relationship between HIV...
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This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by...
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#1Damilohun Samuel Metibemu (FUNAAB: Federal University of Agriculture, Abeokuta)H-Index: 6
#2Oluseyi Adeboye Akinloye (FUNAAB: Federal University of Agriculture, Abeokuta)H-Index: 10
Last. Idowu Olaposi Omotuyi (Adekunle Ajasin University)H-Index: 2
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Abstract Vascular endothelial growth factor (VEGF) and its receptor-2 (VEGFR-2) mediated tumorigenesis, metastasis, and angiogenesis are the cause of the increased levels of mortality associated with breast cancer and other forms of cancer. Inhibition of VEGF and VEGFR-2 provides a great therapeutic option in the management of cancer. This study employed VEGFR-2 kinase domain inhibition as an anti-angiogenic scaffold and further validate the anti-angiogenic effects of the lead phytochemicals, ca...
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#1Jude Ogechukwu Okoye (Nnamdi Azikiwe University)H-Index: 5
#2Simon I Okekpa (Ebonyi State University)H-Index: 3
Last. Anthony Ajuluchukwu Ngokere (Nnamdi Azikiwe University)H-Index: 3
view all 5 authors...
Summary Background Cervical Cancer is the 6th most common and 3rd most deadly cancer among women. Despite the fact that majority of the countries in Asia and Africa have similar economy and low life expectancy, the mean age standardized incidence rate (ASIR) of cervical cancer is substantially higher in Africa than Asia. Thus, this study aimed to identify the correlates of the higher ASIR rates in Africa relative to Asia. Methods Peer-reviewed articles published between 2004 and 2017 were select...
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#1Jude Ogechukwu Okoye (Nnamdi Azikiwe University)H-Index: 5
#2Anthony Ajuluchukwu Ngokere (Nnamdi Azikiwe University)H-Index: 3
Source
#1Damilohun Samuel Metibemu (FUNAAB: Federal University of Agriculture, Abeokuta)H-Index: 6
#2Oluseyi Adeboye Akinloye (FUNAAB: Federal University of Agriculture, Abeokuta)H-Index: 10
Last. Idowu Olaposi Omotuyi (Adekunle Ajasin University)H-Index: 2
view all 7 authors...
Breast cancer is the most prevalent cancer in women. X-linked inhibitor of apoptosis protein (XIAP) that is constantly overexpressed in cancer is a promising therapeutic target in cancer treatments. The mechanisms of the anticancer effects of carotenoid isolates of Spondias mombim in DMBA-induced breast cancer in Wistar rats through XIAP antagonism were investigated in the present study. Carotenoids isolated from the leaves of Spondias mombim were subjected to Liquid Chromatography/Mass Spectrom...
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