Michael J.D. Nugent
Athlone Institute of Technology
Self-healing hydrogelsDrug carrierElectrospinningComposite materialFourier transform infrared spectroscopyNanotechnologyChemistryPolymer chemistryLower critical solution temperatureMaterials scienceSwellingPolyvinyl alcoholCelluloseDrug deliveryAlloyPolyacrylic acidAcrylic acidVinyl alcoholFood scienceDifferential scanning calorimetryChemical engineeringPolymerMedicineNanofiber
49Publications
13H-index
704Citations
Publications 53
Newest
Last. Michael J.D. NugentH-Index: 13
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#1Bor Shin Chee (Athlone Institute of Technology)H-Index: 4
#2G. G. de Lima (Athlone Institute of Technology)
Last. Michael J.D. Nugent (Athlone Institute of Technology)H-Index: 13
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Abstract null null Polyvinyl alcohol/polyacrylic acid (PVA/PAA) bilayer hydrogel nanofibres were successfully fabricated by electrospinning and physically crosslinked via heat treatment. The effects of the thermal annealing process on the structure, morphology, swelling, thermal properties and hydrophilicity of electrospun nanofibres were investigated. In addition, these membranes were also used to incorporate doxorubicin and clarithromycin for osteosarcoma treatment, one in each layer. These dr...
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#2Michael J.D. Nugent (Athlone Institute of Technology)H-Index: 13
Last. Marion McAfeeH-Index: 14
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In the last few decades, hot-melt extrusion (HME) has emerged as a rapidly growing technology in the pharmaceutical industry, due to its various advantages over other fabrication routes for drug delivery systems. After the introduction of the ‘quality by design’ (QbD) approach by the Food and Drug Administration (FDA), many research studies have focused on implementing process analytical technology (PAT), including near-infrared (NIR), Raman, and UV–Vis, coupled with various machine learning alg...
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#1Viviane Seba (Athlone Institute of Technology)H-Index: 3
#2Gabriel Goetten de Lima (Athlone Institute of Technology)H-Index: 9
Last. Luis Octávio Regasini (UNESP: Sao Paulo State University)H-Index: 26
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Chalcones (1,3-diaryl-2-propen-1-ones) are naturally occurring polyphenols with known anticancer activity against a variety of tumor cell lines, including osteosarcoma (OS). In this paper, we present the preparation and characterization of spheres (~2 mm) from polyvinyl alcohol (PVA) containing a combination of 4′-Amino-1-Naphthyl-Chalcone (D14) and doxorubicin, to act as a new polymeric dual-drug anticancer delivery. D14 is a potent inhibitor of osteosarcoma progression and, when combined with ...
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The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechan...
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#1Gabriel Goetten de Lima (Athlone Institute of Technology)H-Index: 9
#2Rêydila Rayenne Caminhas Barbosa (Athlone Institute of Technology)
Last. Michael J.D. Nugent (Athlone Institute of Technology)H-Index: 13
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Unidirectional freeze casting for polymers and ceramics has been performed extensively; however, the mechanisms involved in unidirectional freezing are not thoroughly understood and therefo...
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#1Marina Bandeira (Athlone Institute of Technology)H-Index: 5
#2Bor Shin Chee (Athlone Institute of Technology)H-Index: 4
Last. Declan M. Devine (Athlone Institute of Technology)H-Index: 20
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Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs are a promising antimicrobial nanomaterial with high activity against a range of microorganisms, including drug-resistant bacteria. The electrospun fibers were obtained using polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) and were loaded wi...
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#1Gregory Beilner (UFPR: Federal University of Paraná)H-Index: 1
#2Bruno Leandro Pereira (UFPR: Federal University of Paraná)H-Index: 5
Last. Michael J.D. NugentH-Index: 13
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Among titanium alloys with non-toxic elements, the Ti-25Nb-25Ta alloy has good elastic behavior for applications in osseous implants, biocompatibility, and excellent corrosion resistance. The present study aimed to better the biocompatibility characteristics of Ti-25Nb-25Ta alloy modifying its surface through Plasma Electrolytic Oxidation (PEO) treatment. The formed oxide coating is amorphous and composed of two distinct porous formations: smaller hole-shaped pores and larger volcano-like pores....
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#1Bruno Leandro Pereira (UFPR: Federal University of Paraná)H-Index: 5
#2Gregory Beilner (UFPR: Federal University of Paraná)H-Index: 1
Last. Michael J.D. Nugent (Athlone Institute of Technology)H-Index: 13
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Abstract Well-adhered nanotube arrays were produced through the anodizing technique on a Ti-25Nb-25Ta alloy and tribo-mechanically evaluated by nanoindentation and nanoscratch tests. Disregarding substrate effects, the hardness of the nanotube arrays layer was 0.7 ± 0.1 GPa and elastic modulus was
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#1Luiza Steffens Reinhardt (UFCSPA: Universidade Federal de Ciências da Saúde de Porto Alegre)
#2Jeferson Gustavo Henn (UFCSPA: Universidade Federal de Ciências da Saúde de Porto Alegre)
Last. Dinara Jaqueline Moura (UFCSPA: Universidade Federal de Ciências da Saúde de Porto Alegre)H-Index: 21
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The productions of wound dressings involve three key goals: wound protection, suitable environment, and acceleration of the healing process. This study was based on our previous findings of a Plantago australis Lam., Plantaginaceae, hydroethanolic extract and its pronounced wound healing activity, leading to the development of wound dressings containing the extract. The hydroethanolic extract was produced by an ultrasound method, using leaves followed by HPLC characterization. A nanofiber contai...
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