Jason R. Richardson
Florida International University
Internal medicineEndocrinologyDopaminergicNeuroscienceChemistryNeuroprotectionDopamine transporterNeurodegenerationDeltamethrinDiseaseParkinson's diseaseMicrogliaSubstantia nigraDopamineBiochemistryMedicineBiologyNeuroinflammationCell biologyPharmacology
102Publications
28H-index
1,757Citations
Publications 102
Newest
#1Jiyun PengH-Index: 12
#2Min Hee Yi (Mayo Clinic)H-Index: 3
Last. Long Jun WuH-Index: 55
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#1Melissa K. EdlerH-Index: 7
#2Cooper T. Johnson (NEOMED: Northeast Ohio Medical University)
Last. Jason R. Richardson (FIU: Florida International University)H-Index: 28
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Scavenger receptor CD36 contributes significantly to lipid homeostasis, inflammation, and amyloid deposition, while CD36 deficiency is associated with restored cerebrovascular function in an Alzheimer's disease (AD) mouse model. Yet the distribution of CD36 has not been examined in the brain. Here, we characterized CD36 gene and protein expression in the brains of young, middle aged, aged, and elderly male and female C57BL/6J mice. Age-related increases in CD36 mRNA expression were observed in t...
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#1Melissa K. EdlerH-Index: 7
Last. Jason R. RichardsonH-Index: 28
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Microglia are the primary immune cells of the central nervous system that help nourish and support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their environment, microglia go through rapid changes in cell shape, gene expression, and functional behavior during states of infection, trauma, and neurodegeneration. Aging also has a profound effect on microglia, leading to chronic inflammation and an increase in the brain’s susceptibility to neurodegenerative processes t...
1 CitationsSource
#1Melody Wren (RU: Rutgers University)H-Index: 2
#2Min Liu (RU: Rutgers University)H-Index: 9
Last. Brian Buckley (RU: Rutgers University)H-Index: 31
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Abstract Pyrethroid insecticides are commonly used for residential and commercial pest control in the US. Pregnant women and their fetuses are vulnerable to pesticide exposures during critical windows of neurodevelopment. Biomonitoring for exposure requires accurate and sensitive methods to assess exposures during pregnancy. The objective of this study was to develop a sensitive analytical method to measure pyrethroid metabolite concentrations in cord serum. Six pyrethroid metabolites, cis- and ...
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#1Melissa EdlerH-Index: 2
Last. Jason R. RichardsonH-Index: 28
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#1Muhammad M Hossain (NEOMED: Northeast Ohio Medical University)H-Index: 2
#1Muhammad M. Hossain (FIU: Florida International University)H-Index: 13
Last. Jason R. Richardson (FIU: Florida International University)H-Index: 28
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Deficits in learning and memory are often associated with disruption of hippocampal neurogenesis, which is regulated by numerous processes, including precursor cell proliferation, survival, migration, and differentiation to mature neurons. Recent studies demonstrate that adult born neurons in the dentate gyrus (DG) in the hippocampus can functionally integrate into the existing neuronal circuitry and contribute to hippocampal-dependent learning and memory. Here, we demonstrate that relatively sh...
2 CitationsSource
#1Jason R. Richardson (FIU: Florida International University)H-Index: 28
#2Yinsheng Wang (FIU: Florida International University)
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#1Wen-Ning Wu (Anhui Medical University)H-Index: 6
#2Yujiao Li (Fourth Military Medical University)H-Index: 4
Last. Long Jun Wu (Mayo Clinic)H-Index: 55
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Abstract Microglia are the resident immune cells of the center nervous system and participate in various neurological diseases. Here we determined the function of microglia in epileptogenesis using microglial ablation approaches. Three different microglia-specific genetic tools were used, CX3CR1CreER/+:R26iDTA/+, CX3CR1CreER/+:R26iDTR/+, and CX3CR1CreER/+:Csf1rFlox/Flox mice. We found that microglial depletion led to worse kainic acid (KA)-induced status epilepticus, higher mortality rate, and i...
14 CitationsSource
#1Kevin Budge (NEOMED: Northeast Ohio Medical University)H-Index: 1
#1Kevin M. BudgeH-Index: 3
Last. Fayez F. SafadiH-Index: 34
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#1Muhammad M. Hossain (FIU: Florida International University)H-Index: 13
#2Jason R. Richardson (FIU: Florida International University)H-Index: 28
Neurotrophins are a family of growth factors crucial for growth and survival of neurons in the developing and adult brain. Reduction in neurotrophin levels is associated with reduced neurogenesis and cognitive deficits in rodents. Recently, we demonstrated that long-term exposure to low levels of the pyrethroid pesticide deltamethrin causes hippocampal endoplasmic reticulum (ER) stress and learning deficits in mice. Here, we found that nerve growth factor (NGF) mRNA and protein were selectively ...
2 CitationsSource