Xiaobing Li
Jilin University
Internal medicineEndocrinologyProinflammatory cytokineChemistryIn vitroGluconeogenesisOxidative stressHepatocyteKetosisFatty liverNEFALipid oxidationLipid metabolismFatty acid synthaseBiochemistryOxidative phosphorylationSignal transductionVery low-density lipoproteinBiologyProtein kinase A
80Publications
22H-index
1,592Citations
Publications 78
Newest
#1Yuxiang Song (JLU: Jilin University)H-Index: 8
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 9 authors...
Left displaced abomasum (LDA) occurs at high frequency in the early postpartum period and can affect production performance of dairy cows. Clinical diagnosis of LDA is usually done by abdominal auscultation and percussion. The purpose of this study was to explore the potential applicability of blood biomarkers for early warning and diagnosis of LDA in dairy cows. Twenty early postpartum healthy cows and thirty early postpartum LDA cows of similar parity were used. A receiver operating characteri...
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#1Yuxiang SongH-Index: 8
#2Juan J. LoorH-Index: 68
Last. Xinwei LiH-Index: 23
view all 9 authors...
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#1Yu Li (AAU: Anhui Agricultural University)H-Index: 8
#2Hongyan Ding (AAU: Anhui Agricultural University)H-Index: 7
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 13 authors...
Elevated plasma nonesterified fatty acid (NEFA) levels and hepatocytes damage are characteristics of ketosis in dairy cows. Oxidative stress is associated with the pathogenesis of NEFA-induced liver damage. However, the exact mechanism by which oxidative stress mediates NEFA-induced hepatocytes apoptosis and liver injury remains poorly understood. The results of the present study demonstrated that NEFA contribute to reactive oxygen species (ROS) generation, resulting in an imbalance between oxid...
8 CitationsSource
#1Xin Shu (JLU: Jilin University)H-Index: 5
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 12 authors...
Ketosis is a metabolic disease of dairy cows often characterized by high concentrations of ketone bodies and fatty acids, but low milk protein and milk production. The Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) and the mechanistic target of rapamycin (mTOR) signaling pathways are central for the regulation of milk protein synthesis. The effect of high levels of fatty acids on these pathways and beta-casein synthesis are unknown in dairy cows with clinical ke...
1 CitationsSource
#1Meng Chen (JLU: Jilin University)H-Index: 1
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT During the transition period, dairy cows are challenged by increased energy demands and decreased dry matter intake, which can induce a variety of metabolic disorders, especially fatty liver. Dairy cows suffering from mild or moderate fatty liver in this period show no distinct clinical symptoms, indicating the occurrence of adaptive processes. The process of autophagy (an adaptive response) leads to degradation of intracellular components to generate energy and maintains cellular homeo...
1 CitationsSource
#1Xudong Sun (JLU: Jilin University)H-Index: 7
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 11 authors...
Aims: Nuclear factor E2-related factor 2 (Nrf2) is a regulator of cellular oxidative stress and is also involved in lipid metabolism in adipocytes. However, it remains unknown whether Nrf2 is the l...
9 CitationsSource
#1Taiyu Shen (JLU: Jilin University)H-Index: 5
#2Xinwei Li (JLU: Jilin University)H-Index: 23
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 11 authors...
ABSTRACT Ketosis is an important metabolic disease that can negatively affect the production efficiency of dairy cows. Earlier studies have revealed metabolic and inflammatory alterations in the blood associated with ketosis; however, a link between ketosis and hepatic inflammation has not been well documented. The objective of this study was to investigate whether the nuclear factor kappa B (NF-κB) signaling pathway and NLR family pyrin domain containing 3 (NLRP3) inflammasome were activated in...
10 CitationsSource
#1Jihong Dong (JLU: Jilin University)H-Index: 7
#2Juan J. Loor (UIUC: University of Illinois at Urbana–Champaign)H-Index: 68
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 13 authors...
ABSTRACT High blood concentrations of nonesterified fatty acids (NEFA) and altered lipid metabolism are key characteristics of fatty liver in dairy cows. In nonruminants, the mitochondrial membrane protein mitofusin 2 (MFN2) plays important roles in regulating mitochondrial function and intrahepatic lipid metabolism. Whether MFN2 is associated with hepatic lipid metabolism in dairy cows with moderate fatty liver is unknown. Therefore, to investigate changes in MFN2 expression and lipid metabolic...
6 CitationsSource
#1Yiwei Zhu (JLU: Jilin University)H-Index: 9
#2Yuan Guan (JLU: Jilin University)H-Index: 8
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 12 authors...
ABSTRACT Disruption of endoplasmic reticulum (ER) homeostasis, often termed ER stress, is intrinsically linked with perturbation of lipid metabolism in humans and mice. Whether ER homeostasis is affected in cows experiencing fatty liver is unknown. The aim of this study was to investigate the potential role of ER stress in hepatic lipid accumulation in calf hepatocytes and ER stress status in dairy cows with severe fatty liver. In vitro experiments were conducted in which hepatocytes were isolat...
22 CitationsSource
#1Qiushi Xu (JLU: Jilin University)H-Index: 6
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 10 authors...
: Ketosis is a major metabolic disorder of high-yielding dairy cows during the transition period. Although metabolic adaptations of the adipose tissue are critical for a successful transition, beyond lipolysis, alterations within adipose tissue during ketosis are not well known. The objective of this study was to investigate the adipose tissue proteome of healthy or ketotic postpartum cows to gain insights into biological adaptations that may contribute to disease outcomes. Adipose tissue biopsy...
6 CitationsSource