Hemant K. Mishra
University of Minnesota
Internal medicineGenotypeSurgeryCellOdds ratioAntibodyCardiologyRandomized controlled trialReceptorAlleleChemistryImmunologyAngiotensin-converting enzymeObstructive sleep apneaInflammationImmunotherapyPolysomnographySepsisFc receptorMetabolic syndromeCancer immunotherapyTuberculosisPopulationGenotypingAntibody-dependent cell-mediated cytotoxicityCancer researchMedicineCell cultureBiologyGastroenterologyCell biology
32Publications
14H-index
464Citations
Publications 31
Newest
Objectives: To systematically review the clinical literature reporting the use of Lopinavir/ritonavir (LPV/r) for the treatment of patients with COVID-19 to assess the efficacy of LPV/r for the treatment of Cornonavirus disease 19 (COVID-19). Methods: The authors systematically searched PubMed and MedRxiv databases for studies describing treatment of COVID-19 patients using LPV/r compared to other therapies. Articles were excluded if they were case reports, opinion editorials, preclinical studie...
1 CitationsSource
#1Yashwitha Sai Pulakurthi (Academy of Medical Sciences, United Kingdom)H-Index: 2
#2John M. PedersonH-Index: 2
Last. Kirk W. EvansonH-Index: 1
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BACKGROUND Corticosteroid treatment is an effective and common therapeutic strategy for various inflammatory lung pathologies and may be an effective treatment for coronavirus disease 2019 (COVID-19). The purpose of this systematic review and meta-analysis of current literature was to investigate the clinical outcomes associated with corticosteroid treatment of COVID-19. METHODS We systematically searched PubMed, medRxiv, Web of Science, and Scopus databases through March 10, 2021 to identify ra...
1 CitationsSource
#1Charan Thej Reddy Vegivinti (Manipal University)H-Index: 1
#2John M. PedersonH-Index: 2
Last. Ameer E. HassanH-Index: 1
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The purpose of this systematic review and meta-analysis was to examine clinical outcomes associated with convalescent plasma therapy in COVID-19 patients. We performed a literature search on PubMed, medRxiv, Web of Science, and Scopus to identify studies published up to December 10th, 2020 that examined the efficacy of convalescent plasma treatment for COVID-19. The primary endpoints were mortality, clinical improvement, and hospital length of stay. We screened 859 studies that met the search cr...
3 CitationsSource
#1Hemant K. Mishra (UMN: University of Minnesota)H-Index: 14
#2Kate J. Dixon (UMN: University of Minnesota)H-Index: 1
Last. Bruce Walcheck (UMN: University of Minnesota)H-Index: 34
view all 6 authors...
Natural killer (NK) cells are innate cytotoxic lymphocytes that can recognize assorted determinants on tumor cells and rapidly kill these cells. Due to their anti-tumor effector functions and potential for allogeneic use, various NK cell platforms are being examined for adoptive cell therapies. However, their limited in vivo persistence is a current challenge. Cytokine-mediated activation of these cells is under extensive investigation and interleukin-15 (IL-15) is a particular focus since it dr...
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#1Hugues Allard-Chamard (Université de Sherbrooke)H-Index: 7
#2Hemant K. Mishra (UMN: University of Minnesota)H-Index: 14
Last. Sheela RamanathanH-Index: 23
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Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor complexes containing the common gamma (γc) chain for signaling. IL-15 plays important roles in innate and adaptative immune responses and is implicated in the pathogenesis of several immune diseases. The IL-15 receptor consists of 3 subunits namely, the ligand-binding IL-15Rα chain, the β chain (also used by IL-2) and the γc chain. IL-15 uses a unique signaling pathway whereby IL-15 associates with IL-15Rα dur...
3 CitationsSource
#1Patrick Graupman (Boston Children's Hospital)H-Index: 5
#1Patrick C Graupman (Boston Children's Hospital)H-Index: 1
Last. Hemant K. Mishra (UMN: University of Minnesota)H-Index: 14
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Epidural or spinal anesthesia is commonly administered in births in the US, and the potential risks for epidermoid tumors are not well-characterized. We present the case of a 29-year-old female patient who developed an intradural epidermoid tumor in the lumbar spine, discovered seven years after spinal anesthesia for childbirth. MRI revealed a 4 cm tumor filling the entire spinal canal. Pathology confirmed the mass to be an epidermoid. Complete surgical resection of the intradural lesion was acc...
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#1Hemant K. Mishra (UMN: University of Minnesota)H-Index: 14
#2Jing Ma (UMN: University of Minnesota)H-Index: 11
Last. Bruce Walcheck (UMN: University of Minnesota)H-Index: 34
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Sepsis is the culmination of hyperinflammation and immune suppression in response to severe infection. Neutrophils are critical early responders to bacterial infection but can become highly dysfunctional during sepsis and other inflammatory disorders. The transmembrane protease ADAM17 (a disintegrin and metalloproteinase 17) is expressed by leukocytes and most other cells and has many substrates that regulate inflammation. We have reported that conditional knockout mice lacking ADAM17 in all leu...
3 CitationsSource
#1Ziva Atias (Sheba Medical Center)
#2John M. Pederson (UMN: University of Minnesota)H-Index: 2
Last. Shoshana Greenberger (TAU: Tel Aviv University)H-Index: 17
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Objective: The aim of this study was to evaluate the therapeutic effects of natural matrix biopolymer membrane (NMBM) in the treatment of venous leg ulcers (VLUs). Method: Patients exhibiting one o...
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#1Jianming Wu (UMN: University of Minnesota)H-Index: 31
#2Hemant K. Mishra (UMN: University of Minnesota)H-Index: 14
Last. Bruce Walcheck (UMN: University of Minnesota)H-Index: 34
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: Human NK cell antitumor activities involve Ab-dependent cell-mediated cytotoxicity (ADCC), which is a key mechanism of action for several clinically successful tumor-targeting therapeutic mAbs. Human NK cells exclusively recognize these Abs by the Fcγ receptor CD16A (FcγRIIIA), one of their most potent activating receptors. Unlike other activating receptors on NK cells, CD16A undergoes a rapid down-regulation in expression by a proteolytic process following NK cell activation with various stim...
25 CitationsSource
#1Kristin M. Snyder (UMN: University of Minnesota)H-Index: 5
#2Robert Hullsiek (UMN: University of Minnesota)H-Index: 2
Last. Bruce Walcheck (UMN: University of Minnesota)H-Index: 34
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Author(s): Snyder, Kristin M; Hullsiek, Robert; Mishra, Hemant K; Mendez, Daniel C; Li, Yunfang; Rogich, Allison; Kaufman, Dan S; Wu, Jianming; Walcheck, Bruce | Abstract: Anti-tumor mAbs are the most widely used and characterized cancer immunotherapy. Despite having a significant impact on some malignancies, most cancer patients respond poorly or develop resistance to this therapy. A known mechanism of action of these therapeutic mAbs is antibody-dependent cell-mediated cytotoxicity (ADCC), a k...
17 CitationsSource