Gustavo Petri Guerra
Federal University of Technology - Paraná
Internal medicineEndocrinologyNociceptionTransient receptor potential channelTRPV1CREBChemistryIn vivoSpermineResiniferatoxinInflammationPutrescineSpermidineAllodyniaAgonistMemory improvementCapsaicinPolyamineHippocampusAnesthesiaBiochemistryNMDA receptorMedicineProtein kinase APharmacology
23Publications
17H-index
598Citations
Publications 23
Newest
Last. Marina PrigolH-Index: 23
view all 12 authors...
Chronic unpredictable mild stress (CUMS) is a valid model for inducing depression-like symptoms in animal models, causing predictive behavioral, neurochemical, and physiological responses to this condition. This work aims to evaluate the possible antidepressant effect of γ-oryzanol (ORY) in the CUMS-induced depressive model in male Drosophila melanogaster. We will use the CUMS protocol to continue the study previously conducted by our research group, mimicking a depressive state in these insects...
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Abstract The pathogenesis of Parkinson's disease has not been fully clarified yet but its cause is known to be multifactorial. One of these factors is oxidative stress induced by exposure to environmental toxifiers. We studied the effect of Bisphenol A (BPA) at concentrations of 0.5 mM and 1 mM, the concentration of 1 mM corresponding to Lowest Observed Adverse Effect Level (LOAEL) for humans in adult Drosophila melanogaster. The BPA induced oxidative stress was established by increased levels o...
10 CitationsSource
#1Mateus Rossato (USP: University of São Paulo)H-Index: 16
#2Flávia Karine Rigo (Health Science University)H-Index: 17
Last. Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 25
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Abstract The clinical use of paclitaxel as a chemotherapeutic agent is limited by the severe acute and chronic hypersensitivity caused when it is administered via intraperitoneal or intravenous routes. Thus far, evidence has suggested that transient receptor potential vanilloid-1 (TRPV1) has a key role in the chronic neuropathy induced by paclitaxel. Despite this, the role of TRPV1 in paclitaxel -related acute nociception, especially the development of visceral nociception, has not been evaluate...
11 CitationsSource
#1Jéssica Thaís do Prado Silva (UTFPR: Federal University of Technology - Paraná)H-Index: 4
#2Anderson Clayton da Silva (UTFPR: Federal University of Technology - Paraná)H-Index: 3
Last. Odinei Hess Gonçalves (UTFPR: Federal University of Technology - Paraná)H-Index: 16
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Abstract Lutein is a carotenoid presenting known anti-inflammatory and antioxidant properties. Lutein-rich diets have been associated with neurological improvement as well as reduction of the risk of vision loss due to Age-Related Macular Degeneration (AMD). Micro and nanoencapsulation have demonstrated to be effective techniques in protecting lutein against degradation and also in improving its bioavailability. However, actual lutein concentration inside the capsules and encapsulation efficienc...
14 CitationsSource
#1Jéssica Thaís do Prado Silva (UTFPR: Federal University of Technology - Paraná)H-Index: 4
#2Julia Maria Tonin Geiss (UTFPR: Federal University of Technology - Paraná)H-Index: 2
Last. Odinei Hess Gonçalves (UTFPR: Federal University of Technology - Paraná)H-Index: 16
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Abstract Lutein is a xanthophyll carotenoid widely known by its biological properties and low toxicity. When located in the brain, lutein may inhibit damage mechanisms, acting in neural cells maintenance. However, this carotenoid is very sensitive to external agents such as heat, light, pH and oxidation, besides presenting low absorption in gastrointestinal tract due its low solubility in water. Encapsulation procedures have shown promising results to increase lutein stability and bioavailabilit...
25 CitationsSource
#1Gustavo Petri Guerra (UTFPR: Federal University of Technology - Paraná)H-Index: 17
#2Maribel Antonello Rubin (UFSM: Universidade Federal de Santa Maria)H-Index: 35
Last. Carlos Fernando Mello (UFSM: Universidade Federal de Santa Maria)H-Index: 38
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Abstract Spermine and spermidine are natural polyamines that are produced mainly via decarboxylation of l -ornithine and the sequential transfer of aminopropyl groups from S -adenosylmethionine to putrescine by spermidine synthase and spermine synthase. Spermine and spermidine interact with intracellular and extracellular acidic residues of different nature, including nucleic acids, phospholipids, acidic proteins, carboxyl- and sulfate-containing polysaccharides. Therefore, multiple actions have...
39 CitationsSource
#1Cássia Regina Silva (UFSM: Universidade Federal de Santa Maria)H-Index: 21
#2Sara Marchesan Oliveira (UFSM: Universidade Federal de Santa Maria)H-Index: 25
Last. Juliano Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 53
view all 13 authors...
Objective Verify the role of the kinin B 1 receptors (B 1 R) and the effect of ACE inhibitors (ACEi) on acute gout induced by monosodium urate (MSU) crystals in rodents. Methods Painful (overt pain and allodynia) and inflammatory parameters (joint oedema, leukocyte trafficking, interleukin-1β levels) of acute gout attacks were assessed several hours after an intra-articular injection of MSU (1.25 or 0.5 mg/articulation) into the ankle of rats or mice, respectively. The role of B 1 R was investig...
25 CitationsSource
#1Francielle de Vargas Pinheiro (UFSM: Universidade Federal de Santa Maria)H-Index: 9
#2Jardel Gomes Villarinho (UFSM: Universidade Federal de Santa Maria)H-Index: 15
Last. Eunice André (UFSM: Universidade Federal de Santa Maria)H-Index: 20
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Abstract Sympathetic fibres maintain some forms of neuropathic pain, but the underlying mechanisms are poorly understood. Therefore, this study investigated the possible involvement of transient receptor potential ankyrin 1 (TRPA1) and the role of the sympathetic nervous system (involved in sympathetically maintained neuropathic pain) in a model of neuropathic pain induced by sciatic nerve chronic constriction injury (CCI) in mice. Systemic injection of the selective TRPA1 antagonist HC-030031 r...
18 CitationsSource
#1Gabriela Trevisan (UFSM: Universidade Federal de Santa Maria)H-Index: 25
#2Carin Hoffmeister (UFSM: Universidade Federal de Santa Maria)H-Index: 11
Last. Juliano Ferreira (UFSC: Universidade Federal de Santa Catarina)H-Index: 53
view all 14 authors...
Abstract Acute gout attacks produce severe joint pain and inflammation associated with monosodium urate (MSU) crystals leading to oxidative stress production. The transient potential receptor ankyrin 1 (TRPA1) is expressed by a subpopulation of peptidergic nociceptors and, via its activation by endogenous reactive oxygen species, including hydrogen peroxide (H2O2), contributes to pain and neurogenic inflammation. The aim of this study was to investigate the role of TRPA1 in hyperalgesia and infl...
68 CitationsSource
#1Carin Hoffmeister (UFSM: Universidade Federal de Santa Maria)H-Index: 11
#2Mariane Arnoldi Silva (UFSM: Universidade Federal de Santa Maria)H-Index: 13
Last. Juliano Ferreira (UFSM: Universidade Federal de Santa Maria)H-Index: 53
view all 8 authors...
Objective. The aim of the present study was to investigate the participation of TRPV1 in an acute gout attack model. Methods. Experiments were conducted to evaluate the participation of TRPV1 in the nociceptive and inflammatory responses (oedema, plasma extravasation, leucocyte infiltration and also IL-1b production) triggered by IA (ankle) administration of monosodium urate (MSU) in rats using selective antagonist TRPV1 receptor, defunctionalization of sensory fibres and increased immunoreactiv...
23 CitationsSource