Marcus Brand
University of Münster
Fibroblast growth factor 23Internal medicineUrologyCalcineurinEndocrinologyPathologyRenal functionCardiologyMuscle hypertrophyIntensive care medicineLeft ventricular hypertrophyPreeclampsiaKidney diseaseDiseaseSoluble fms-like tyrosine kinase-1ImmunoadsorptionBone marrowKidneyImmunosuppressionKidney transplantationAngiogenesisMultiple sclerosisPathogenesisEndothelial dysfunctionIn patientBlood volumeFibroblast growth factor receptor 4MedicineFibroblast growth factorBlood pressureBiology
36Publications
17H-index
2,556Citations
Publications 36
Newest
Soluble Fms-like tyrosine kinase (sFlt-1/sVEGFR1) is a natural occurring antagonist of vascular endothelial growth factor (VEGF). Despite being a secreted, soluble protein lacking cytoplasmic and transmembrane domains, sFlt-1 can act locally and be protective against excessive microenvironmental VEGF concentration, or exert autocrine functions independently of VEGF. Circulating sFlt-1 may indiscriminately affect endothelial function and the microvasculature on distant target organs. The clinical...
Source
Source
#1Linus A. Völker (University of Cologne)H-Index: 12
#2Jessica KaufeldH-Index: 10
Last. Jan MenneH-Index: 32
view all 42 authors...
Introduction of the nanobody caplacizumab was shown to be effective in the treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in the acute setting. The official recommendations include plasma exchange (PEX), immunosuppression, and the use of caplacizumab for a minimum of 30 days after stopping daily PEX. This study was a retrospective, observational analysis of the use of caplacizumab in 60 patients from 29 medical centers in Germany. Immunosuppressive treatment led to a rapid norm...
Source
Preeclampsia is one of the most feared complications of pregnancy and puerperium and represents a serious threat to mother and child. In addition, a history of preeclampsia increases the risk of future cardiovascular events. New diagnostic and therapeutic approaches are needed. New therapeutic options are currently being discussed, one of which is the administration of hydroxychloroquine. It is an antimalarial drug which is also used to treat rheumatological disease and its use in pregnancy is c...
Source
#1Linus A. Völker (University of Cologne)H-Index: 12
#2Jessica KaufeldH-Index: 10
Last. Jan MenneH-Index: 32
view all 42 authors...
Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare but life-threatening condition. In 2018, the nanobody caplacizumab was approved for the treatment of adults experiencing an acute episode of aTTP, in conjunction with plasma exchange (PEX) and immunosuppression for a minimum of 30 days after stopping daily PEX. We performed a retrospective, observational analysis on the use of caplacizumab in 60 patients from 29 medical centers in Germany during acute disease management. Caplacizumab ...
Source
#1Bettina HesseH-Index: 3
#2Alexandros RovasH-Index: 7
Last. Alexander Lukasz (WWU: University of Münster)H-Index: 5
view all 12 authors...
Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against vascular diseases including atherosclerosis. Here we conducted a translational, cross-sectional study to determine the role of symmetric dimethylargi...
Source
#1Steffen Pfeuffer (WWU: University of Münster)H-Index: 12
#2Leoni Rolfes (WWU: University of Münster)H-Index: 6
Last. Sven G. Meuth (WWU: University of Münster)H-Index: 64
view all 12 authors...
Intravenous methyl prednisolone (IVMPS) represents the standard of care for multiple sclerosis (MS) relapses, but fail to improve symptoms in one quarter of patients. In this regard, apart from extending steroid treatment to a higher dose, therapeutic plasma exchange (TPE) has been recognized as a treatment option. The aim of this retrospective, monocentric study was to investigate the efficacy of TPE versus escalated dosages of IVMPS in refractory MS relapses. An in-depth medical chart review w...
Source
Multiple sclerosis (MS) is the most abundant inflammatory demyelinating disorder of the central nervous system. Despite recent advances in its long-term immunomodulatory treatment, MS patients still suffer from relapses, significantly contributing to disability accrual. In recent years, apheresis procedures such as therapeutic plasma exchange (TPE) and immunoadsorption (IA) have been recognized as two options for treating MS relapses, that do not respond to standard treatment with corticosteroid...
Source
#1Theresa M. WewersH-Index: 1
#2Anna B. MayerH-Index: 3
Last. Giovana Seno Di MarcoH-Index: 19
view all 12 authors...
Renal ischemia reperfusion injury (IRI) adversely affects clinical outcomes following kidney transplantation. Understanding the cellular mechanisms and the changes in gene/protein expression following IRI may help to improve these outcomes. Serum soluble fms-like tyrosine kinase 1 (sFlt-1), a circulating antiangiogenic protein, is increased in the first week following kidney transplantation. We evaluated the casual relationship of elevated sFlt-1 levels with renal microvascular dysfunction follo...
Source
#1Frank Hoffmann (Wittenberg University)H-Index: 10
#2Andrea Kraft (Wittenberg University)H-Index: 5
Last. Sebastian SchimrigkH-Index: 22
view all 25 authors...
Background: Up to every fourth woman with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) suffers a clinically relevant relapse during pregnancy. High doses of steroids bear some serious risks, especially within the first trimester of pregnancy. Immunoadsorption (IA) is an effective and more selective treatment option in disabling MS relapse than plasma exchange. Data on the use of IA during pregnancy and breastfeeding are scarce. Methods: In this retrospective multicen...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.