Manjusha Kulkarni
Ohio State University
Interquartile rangeInternal medicineInnate immune systemViral loadCatalysisReceptorTumor necrosis factor alphaChemistryPolyunsaturated fatty acidMaterials scienceImmunologySystemic inflammationStatinInflammationType 2 diabetesInsulin resistanceTrypanosoma cruziCD14MagaininDiseaseZonulinEmtricitabineBody mass indexLipidomeRosuvastatinLeishmaniaMonocytePopulationAntiretroviral therapyHuman immunodeficiency virus (HIV)Immune activationChemical engineeringAntimicrobial peptidesBiochemistryPhotocatalysisMedicineCohortIntracellularBiologyImmune systemMicrobiologyGastroenterologyPharmacology
47Publications
16H-index
776Citations
Publications 45
Newest
#1Scott A. Scarneo (Duke University)H-Index: 3
#2Aaron P. Smith (Duke University)H-Index: 2
Last. Manjusha Kulkarni (OSU: Ohio State University)H-Index: 16
view all 16 authors...
Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified an extracellularly expressed form of Hsp90, eHsp90, that previously appeared to be restricted to rapidly proliferating cells exhibiting a metastatic phenotype. Here, we used HS-131, a fluor-tethered eHsp90 inhibitor, to quantify the effect of T cell activation on the expression of eHsp90 in human and mou...
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#1Emily R. Bowman (OSU: Ohio State University)H-Index: 11
#2Cheryl M. Cameron (Case Western Reserve University)H-Index: 19
Last. Nicholas T. Funderburg (OSU: Ohio State University)H-Index: 33
view all 18 authors...
Background: The use of antiretroviral therapy (ART) as pre-exposure prophylaxis (PrEP) is an effective strategy for preventing HIV acquisition. The cellular consequences of PrEP exposure, however, have not been sufficiently explored to determine potential effects on health in individuals without HIV.Methods: Peripheral blood mononuclear cells (PBMCs) from people without HIV were exposed to tenofovir disoproxil fumarate (TDF) or emtricitabine (FTC) overnight. Mitochondrial mass and function were ...
1 CitationsSource
#1Emily R. Bowman (OSU: Ohio State University)H-Index: 11
#2Manjusha Kulkarni (OSU: Ohio State University)H-Index: 16
Last. Nehal N. Mehta (NIH: National Institutes of Health)H-Index: 62
view all 19 authors...
Dyslipidemia often accompanies human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART). Lipid abnormalities likely contribute to increased cardiometabolic disease among people with HIV (PWH). Here, we expand our previous findings on changes in the lipidome following ART initiation, and associations among lipid species, including ceramides (CER), diacylglycerols (DAG), and triacylglycerols (TAG), with immune activation. Concentrations and fatty acid composition of plasma lip...
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#1Emily R. Bowman (OSU: Ohio State University)H-Index: 11
#2Cheryl M. Cameron (Case Western Reserve University)H-Index: 19
Last. Nicholas T. Funderburg (OSU: Ohio State University)H-Index: 33
view all 20 authors...
People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease (ASCVD). Proportions of vascular homing monocytes are enriched in PWH; however, little is known regarding monocyte-derived macrophages (MDMs) that may drive atherosclerosis in this population. We isolated PBMCs from people with and without HIV, and cultured these cells for 5 days in medium containing autologous serum to generate MDMs. Differential gene expression (DGE) analysis of MDMs from PWH identified broa...
4 CitationsSource
#1Sahera Dirajlal-Fargo (Case Western Reserve University)H-Index: 8
#2Zainab Albar (Case Western Reserve University)H-Index: 2
Last. Grace A. McComsey (Case Western Reserve University)H-Index: 59
view all 10 authors...
We aimed to evaluate differences in socio-economic variables in a Ugandan cohort of children with perinatally acquired HIV (PHIVs), HIV exposed uninfected (HEU) and HIV unexposed uninfected (HIV-) children and their associations with markers of inflammation and intestinal integrity. This is a cross-sectional study in 57 PHIV, 59 HEU and 56 HIV - children aged 2-10 years old enrolled in Uganda. Mean age of all participants was 7 years and 55% were girls. Compared to HEU and HIV - children, PHIVs ...
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#1Sahera Dirajlal-Fargo (Case Western Reserve University)H-Index: 8
#2Vanessa El-Kamari (Case Western Reserve University)H-Index: 2
Last. Grace A. McComsey (Case Western Reserve University)H-Index: 59
view all 12 authors...
BACKGROUND: Children with perinatally acquired HIV (PHIVs) face a lifelong cumulative exposure to HIV and ART. The relationship between gut integrity, microbial translocation and inflammation in PHIV is poorly understood. METHODS: This is a cross-sectional study in 57 PHIVs, 59 HIV exposed uninfected (HEUs) and 56 HIV unexposed uninfected (HIV-) children aged 2-10 years old in Uganda. PHIVs were on stable ART with HIV-1 RNA 0.05). Among PHIVs who were breastfed, levels of sCD163 and IL6 were hig...
11 CitationsSource
#2Lingpeng Shan (Case Western Reserve University)H-Index: 3
Last. Grace A. McComseyH-Index: 59
view all 11 authors...
Selenium, zinc and chromium are essential micronutrients. Their alterations have been associated with HIV disease progression, metabolic complications and mortality.This is a cross-sectional study in children with perinatally acquired HIV (PHIV, n = 57), HIV exposed uninfected (HEU, n = 59) and HIV unexposed uninfected (HIV-, n = 56) children aged 2-10 years old, age and sex matched, enrolled in Uganda. PHIV were on stable antiretroviral therapy (ART) with undetectable viral load. We measured pl...
3 CitationsSource
#1Sahera Dirajlal-Fargo (Case Western Reserve University)H-Index: 8
#2Lingpeng Shan (Case Western Reserve University)H-Index: 3
Last. Grace A. McComsey (Case Western Reserve University)H-Index: 59
view all 10 authors...
OBJECTIVES: The risk of cardiometabolic complications in children with perinatally acquired HIV infection (PHIVs) and in perinatally HIV-exposed but uninfected children (HEUs) and its relationship to systemic inflammation and markers of gut integrity are not well established. In this current study, we assed insulin resitance in PHIV compared to HEUs and HIV unexposed uninfected children and explored potential association with intestinal damage biomarkers. METHODS: This was a cross-sectional stud...
1 CitationsSource
#1Sahera Dirajlal-Fargo (Case Western Reserve University)H-Index: 8
#2Jiao Yu (Case Western Reserve University)H-Index: 1
Last. Grace A. McComsey (Boston Children's Hospital)H-Index: 5
view all 7 authors...
OBJECTIVE: In this study, we explored the effect of zinc supplementation on markers of inflammation and monocyte activation in antiretroviral therapy-treated HIV infection. METHODS: This is a phase I open-labeled randomized double-arm study, exploring the efficacy and safety of zinc supplementation on inflammation in ≥18-year-old people living with HIV in the US, on stable antiretroviral therapy and with zinc levels ≤75 µg/dL in the last 60 days. Patients were randomized 1:1 to zinc gluconate ca...
5 CitationsSource
#1Marjorie M. Kelley (OSU: Ohio State University)H-Index: 6
#2Randi E. Foraker (WashU: Washington University in St. Louis)H-Index: 22
Last. Kathryn E. Weaver (Wake Forest University)H-Index: 32
view all 6 authors...
Background Cardiovascular (CV) disease continues to be a leading cause of morbidity and mortality with higher rates among cancer survivors than in the general population. Objective This study was aimed to understand oncology providers' attitudes toward a digital CV health tool, delivered via a tablet, to promote CV health in cancer survivors. Methods Using qualitative methods, 14 oncologists, from community and academic practice sites, were interviewed while they used the tool. Interviews were v...
2 CitationsSource