Marzia Cirri
University of Florence
Drug carrierNuclear chemistryDissolution testingSolubilityOrganic chemistryBioavailabilityAqueous solutionChemistryInclusion compoundCyclodextrinChitosanDrug deliveryDrugDifferential scanning calorimetryChemical engineeringChromatographyPermeationTernary operationDosage formDissolution
73Publications
33H-index
2,511Citations
Publications 74
Newest
#1Paola MuraH-Index: 50
Last. Marzia CirriH-Index: 33
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The aim of this study was the optimization of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in terms of physicochemical and biopharmaceutical properties, to develop effective and stable aqueous liquid formulations of hydrochlorothiazide, suitable for paediatric therapy, overcoming its low-solubility and poor-stability problems. Based on solubility studies, Precirol® ATO5 and Transcutol® HP were used as solid and liquid lipids, respectively. The effect of different surfa...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Metronidazole is the drug of choice in the treatment of bacterial vaginosis, but the oral therapy can induce several collateral effects. Aim of this work was the development of a vaginal multiparticulate system loaded with metronidazole able to improve its residence time allowing a complete drug release. Several kinds of MS were prepared using chitosan dissolved in different organic acids or alginate coated with chitosan. FTIR and DSC analyses were performed to study the interactions be...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Abstract Hydrochlorothiazide (HCT) is widely used in pediatrics for hypertension management. Due to the lack of pediatric commercial forms, community or hospital pharmacies generally prepare HCT extemporaneous pediatric suspensions by dispersing in water a portion of a crushed tablet or the drug powder; however, any dose or stability control is usually done on these preparations. Obtaining stable HCT solutions is very challenging, due to its low water-solubility and pH-dependent degradation. The...
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#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Paola Mura (UniFI: University of Florence)H-Index: 50
Last. Letizia Brunetti (UniFI: University of Florence)H-Index: 1
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The aim of this work was to evaluate the effectiveness of mesoporous clays or silicas to develop fast-dissolving glyburide tablets based on a liquisolid approach. Selected clay (Neusilin®US2) and silica (Aeroperl®300) allowed preparation of innovative drug liquisolid systems containing dimethylacetamide or 2-pyrrolidone as drug solvents, without using coating materials which are necessary in conventional systems. The obtained liquisolid powders were characterized for solid-state properties, flow...
2 CitationsSource
#1Yasamin Soleimanian (IUT: Isfahan University of Technology)H-Index: 2
#2Sayed Amir Hossein Goli (IUT: Isfahan University of Technology)H-Index: 20
Last. Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
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The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble bioactive component with hypocholesterolemic activity. Two β-sitosterol formulations with different solid lipid compositions were prepared by melt emulsification, followed by the sonication technique, and the effect of storage conditions and simulated digestion on the physical, chemical and oxidative stability, bioaccessib...
1 CitationsSource
#1Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
#2Marzia Cirri (UniFI: University of Florence)H-Index: 33
Last. Paola Mura (UniFI: University of Florence)H-Index: 50
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Hydrochlorothiazide (HCT), a Biopharmaceutical Classification System (BCS) class IV drug, is characterized by low solubility and permeability, that negatively affect its oral bioavailability, reducing its therapeutic efficacy. The combined use of cyclodextrins (CDs) and nanoclays (NCs) recently proved to be a successful strategy in developing delivery systems able to merge the potential benefits of both carriers. In this work, several binary systems of CDs or NCs with the drug were obtained, usi...
5 CitationsSource
#1Paola Mura (UniFI: University of Florence)H-Index: 50
#2Maurizio ValleriH-Index: 6
Last. Marzia Cirri (UniFI: University of Florence)H-Index: 33
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Abstract This work evaluated the suitability of various mesoporous silicas as carriers for developing an oral formulation endowed with improved dissolution properties of glibenclamide, hypoglycemic agent poorly water-soluble. The different silicas were examined for solid-state, morphology, and technological and physical-chemical properties (granulometry, specific surface area, wettability, water content, water activity, apparent density, flowability, compactability). A pairwise comparison allowe...
8 CitationsSource
#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Francesca Maestrelli (UniFI: University of Florence)H-Index: 27
Last. Lorenzo Di Cesare Mannelli (UniFI: University of Florence)H-Index: 36
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The development of specific and age-appropriate pediatric formulations is essential to assure that all children and their care-givers can easily access to safe and effective dosage forms. The need for developing specific pediatric medicinal products has been highlighted by the European Medicines Agency. The aim of this study was to investigate the effectiveness of combining the advantages of both cyclodextrin (CD) complexation and loading into nanostructured lipid carriers (NLC), to obtain a liq...
7 CitationsSource
#1Marzia Cirri (UniFI: University of Florence)H-Index: 33
#2Lavinia MaestriniH-Index: 1
Last. Lorenzo Di Cesare Mannelli (UniFI: University of Florence)H-Index: 36
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AbstractThe hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous drug distribution very difficult. Thus, the aim of this study was to investigate the effectiveness of a strategy based on the development of nanostructured lipid carriers (NLC) as an innovative oral pediatric formulation of HCT with improved t...
34 CitationsSource
#1Marco Bragagni (UniFI: University of Florence)H-Index: 16
#2Maria Esther Gil-Alegre (Complutense University of Madrid)H-Index: 8
Last. Lorenzo Di Cesare Mannelli (UniFI: University of Florence)H-Index: 36
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Abstract A delivery system based on poly(lactic-co-glycolic acid) polymer (PLGA) microparticles has been developed for parenteral administration of the local anesthetic prilocaine in its free base form. Both drug-free and drug-loaded microparticles, prepared by a double-emulsion-evaporation method, were characterized for mean size by Laser Diffraction Analysis, while their morphology was investigated by scanning electron microscopy. The preparation technique allowed obtainment of homogeneous mic...
12 CitationsSource