Akihiro Katayama
Okayama University
Internal medicineDownregulation and upregulationEndocrinologySurgeryEndoplasmic reticulumRenal functionAdipose tissuePediatricsApoptosisAdipokineType 2 diabetesInsulinDiabetic nephropathyGlycemicHypoglycemiaNephropathyType 1 diabetesDiabetes mellitusMedicineProtein kinase BBiologyGastroenterology
32Publications
12H-index
548Citations
Publications 35
Newest
#1Tomokazu Nunoue (Okayama University)H-Index: 4
#2Satoshi Yamaguchi (Okayama University)H-Index: 4
Last. Jun Wada (Okayama University)H-Index: 64
view all 8 authors...
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Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections. We herein present a case of a 40-year-old woman with type 2 diabetes mellitus who had been diagnosed with subcutaneous insulin resistance syndrome since the age of 29 years, and had been persistently treated with continuous subcutaneous insulin infusion using a mixture of insulin lispro and heparin. The patient was switched from insu...
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#1Noriko Fujiwara (Okayama University)
#2Mayu Watanabe (Okayama University)H-Index: 3
Last. Jun Wada (Okayama University)H-Index: 64
view all 8 authors...
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#1Koki MiseH-Index: 17
#2Mariko ImamuraH-Index: 1
Last. Jun WadaH-Index: 64
view all 25 authors...
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#1Tomokazu Nunoue (Okayama University)H-Index: 4
#2Satoshi Yamaguchi (Okayama University)H-Index: 4
Last. Jun Wada (Okayama University)H-Index: 64
view all 8 authors...
The adipose tissue is regarded as an endocrine organ and secretes bioactive adipokines modulating chronic inflammation and oxidative stress in obesity. Gal-9 is secreted out upon cell injuries, interacts with T-cell immunoglobulin-3 (Tim-3) and induces apoptosis in activated Th1 cells. Gal-9 also binds to protein disulfide isomerase (PDI), maintains PDI on surface of T cells, and increases free thiols in the disulfide/thiol cycles. To explore the molecular mechanism of obesity, we investigated G...
Source
#1Akihiro Katayama (Okayama University)H-Index: 12
#2Atsuhito ToneH-Index: 8
Last. Jun Wada (Okayama University)H-Index: 64
view all 9 authors...
Aims/introduction The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.
Source
#1Satoshi Yamaguchi (Okayama University)H-Index: 4
#2Atsuhito ToneH-Index: 8
Last. Jun WadaH-Index: 64
view all 12 authors...
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#1Mayu Watanabe (Okayama University)H-Index: 3
#2Akihiro Katayama (Okayama University)H-Index: 12
Last. Jun Wada (Okayama University)H-Index: 64
view all 5 authors...
Poor maternal glycemic control increases maternal and fetal risk for adverse outcomes, and strict management of gestational diabetes mellitus (GDM) is recommended to prevent neonatal and maternal complications. However, risk factors for the requirement of antenatal insulin treatment (AIT) are not well-investigated in the pregnant women with GDM. We enrolled 37 pregnant women with GDM and investigated the risk for AIT by comparing the patients with AIT (AIT group; ) and without insulin therapy (D...
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#1Kazutoshi Murakami (Okayama University)H-Index: 14
#2Jun Eguchi (Okayama University)H-Index: 23
Last. Jun Wada (Okayama University)H-Index: 64
view all 12 authors...
Coxsackie virus and adenovirus receptor-like membrane protein (CLMP) was identified as the tight junction–associated transmembrane protein of epithelial cells with homophilic binding activities. CLMP is also recognized as adipocyte adhesion molecule (ACAM), and it is upregulated in mature adipocytes in rodents and humans with obesity. Here, we present that aP2 promoter–driven ACAM transgenic mice are protected from obesity and diabetes with the prominent reduction of adipose tissue mass and smal...
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#1Atsuko Nakatsuka (Okayama University)H-Index: 17
#2Makoto MatsuyamaH-Index: 14
Last. Jun WadaH-Index: 64
view all 14 authors...
Although obesity is undoubtedly major risk for non-alcoholic steatohepatitis (NASH), the presence of lean NASH patients with normal body mass index has been recognized. Here, we report that the insufficiency of phosphatidylethanolamine N-methyltransferase (PEMT) is a risk for the lean NASH. The Pemt−/− mice fed high fat-high sucrose (HFHS) diet were protected from diet-induced obesity and diabetes, while they demonstrated prominent steatohepatitis and developed multiple liver tumors. Pemt exerte...
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