Arabinda Chaudhuri
Indian Institute of Chemical Technology
Genetic enhancementDrug carrierGene deliveryMolecular biologyCationic liposomeReporter geneDNA vaccinationCationic polymerizationLiposomeChemistryIn vitroIn vivoGenetic transferCancer researchTransfectionDNABiochemistryAmphiphileStereochemistryCell cultureBiologyImmune systemPharmacology
85Publications
25H-index
2,461Citations
Publications 70
Newest
#1Soumen Saha (Indian Institute of Chemical Technology)H-Index: 4
#2Venu Yakati (Indian Institute of Chemical Technology)H-Index: 3
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
view all 10 authors...
Combating brain tumors (Glioblastoma multiforme or GBM) is a formidable challenge because of the existence of blood-brain barrier (BBB), a tight cellular junction that separates central nervous system (CNS) and systemic circulation. Such selectively permeable barrier prevents the entry of therapeutic molecules from blood circulation to brain parenchyma. Towards enhancing the efficacy of brain tumor-selective drug delivery without perturbing the BBB integrity, nanometric drug carriers are increas...
9 CitationsSource
#1Venugopal Vangala (Indian Institute of Chemical Technology)H-Index: 2
#2Narendra Varma Nimmu (Indian Institute of Chemical Technology)H-Index: 4
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
view all 7 authors...
Glioblastoma multiforme (GBM) is one of the most aggressive tumors with median survival of only 15 months. Effective therapeutics need to overcome the formidable challenge of crossing the blood brain barrier (BBB). Receptors and transporters overexpressed on BCECs are being used for designing liposomes, polymers, polymeric micelles, peptides and dendrimer-based drug carriers for combating brain tumors. Herein, using orthotopic mouse glioblastoma model, we show that co-delivering small molecule i...
4 CitationsSource
#1Rakeshchandra R. Meka (Indian Institute of Chemical Technology)H-Index: 6
#2Sudip Mukherjee (Indian Institute of Chemical Technology)H-Index: 24
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
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Since mannose receptors (MRs) are expressed on the surfaces of dendritic cells (DCs), the most professional antigen presenting cells in our body, DNA vaccine carriers containing either covalently grafted mannosyl- or mannose-mimicking shikimoyl-ligands are being increasingly used in ex vivo DC-transfection based DNA vaccination. To this end, we have recently demonstrated that ex vivo immunization of mice with liposomes of shikimoylated cationic amphiphiles containing a 6-amino hexanoic acid spac...
25 CitationsSource
Therapeutic agents harboring both wound healing and antibacterial activities have much demand in biomedical applications. Development of such candidates with clinically approved materials adds more advantages toward these applications. Recently, silver metal complex nanomaterials have been playing a major role in medical uses especially for antibacterial activity and wound healing. In this report, we designed and synthesized silver nitroprusside complex nanoparticles (abbreviated as AgNNPs) usin...
17 CitationsSource
#1Suresh Kumar Gulla (Indian Institute of Chemical Technology)H-Index: 5
#2Rajesh Kotcherlakota (Indian Institute of Chemical Technology)H-Index: 11
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
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Numerous prior studies on fighting cancer have been based on using inhibitors of JAK-STAT pathway (signal transducer and activator of transcription 3 (STAT3) inhibitor in particular), a signaling pathway responsible for progression of many types of cancer cells. However, recent studies have shown that STAT3 activation leads to upregulation of program death receptor-ligand 1 (PD-L1, an immune checkpoint protein that plays a major role behind evasion of immune systems by growing tumors) expression...
11 CitationsSource
#1Poulami Majumder (Indian Institute of Chemical Technology)H-Index: 4
#2Sukanya Bhunia (Indian Institute of Chemical Technology)H-Index: 5
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
view all 3 authors...
Limited tumor tissue penetration is one of the key impeding factors retarding successful in vivo exploitations of anti-angiogenic cancer therapy. Herein we report on the design of a cell penetrating peptide-decorated lipid nano-assembly which, upon systemic administration, induces significant mouse tumor growth inhibition via enhanced tumor infiltration of encapsulated anti-angiogenic siRNA.
25 CitationsSource
#1Priya DharmalingamH-Index: 4
#2Hari Krishna R. Rachamalla (Indian Institute of Chemical Technology)H-Index: 1
Last. Srujan MarepallyH-Index: 14
view all 10 authors...
Cationic lipid-guided nucleic acid delivery holds great promise in gene therapy and genome-editing applications for treating genetic diseases. However, the major challenge lies in achieving therapeutically relevant efficiencies. Prior findings, including our own, demonstrated that asymmetry in the hydrophobic core of cationic lipids imparted superior transfection efficiencies. To this end, we have developed a lipid nanocarrier system with an asymmetric hydrophobic core (PS-Lips) derived from a m...
12 CitationsSource
#1Sukanya Bhunia (Indian Institute of Chemical Technology)H-Index: 5
#2Venugopal Vangala (Indian Institute of Chemical Technology)H-Index: 2
Last. Arabinda Chaudhuri (Indian Institute of Chemical Technology)H-Index: 25
view all 8 authors...
Despite significant progress in neurosurgery and radiation therapy during the past decade, overall survivability (OS) of glioblastoma patients continues to be less than 2 years. The scope of systemic chemotherapy is greatly limited by poor drug transport across the blood brain barrier (BBB) and, thereby, suboptimal drug accumulation in glioma tissue. To this end, use of large amino acid transporter-1 (LAT1) overexpressed both on brain capillary endothelial cells (BCECs) and glioma cells has begu...
24 CitationsSource
#1Krishnendu Das (IACS: Indian Association for the Cultivation of Science)H-Index: 11
#2Sahithi Nimushakavi (Indian Institute of Chemical Technology)H-Index: 3
Last. Prasanta Kumar Das (IACS: Indian Association for the Cultivation of Science)H-Index: 34
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Herein we report the design and development of α5β1 integrin-specific noncovalent RGDK–lipopeptide-functionalized single-walled carbon nanotubes (SWNTs) that selectively deliver the anticancer drug curcumin to tumor cells. RGDK tetrapeptide-tagged amphiphiles were synthesized that efficiently disperse SWNTs with a suspension stability index of >80 % in cell culture media. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)- and lactate dehydrogenase (LDH)-based cell viability assa...
9 CitationsSource
#1Ankita A. HiwaleH-Index: 4
Last. Praveen Kumar VemulaH-Index: 27
view all 12 authors...
The success of gene therapy critically depends on the availability of efficient transfection vectors. Cationic lipids are the most widely studied non-viral vectors. The molecular architecture of the cationic lipid determines its transfection efficiency. Variations in alkyl chain lengths of lipids influence self-assembly and liposomal fusion with the cell membrane. These factors determine the transfection ability of the lipid. Thus, to probe the effect of asymmetry in hydrophobic chains on transf...
8 CitationsSource