Yaozu Xiang
Tongji University
Internal medicineDownregulation and upregulationEndocrinologyIntensive care medicineChemistryTraditional Chinese medicineImmunologyAutophagyAlternative medicineVon Willebrand factorMEDLINECardioprotectionADAMTS13HyperinsulinemiaPlatelet activationSecretionP2Y12Myocardial infarctionFamily medicineClinical trialBiochemistryDiabetes mellitusTraditional medicineScale (social sciences)MedicineBiologyScissile bondMicrobiologyPlateletCell biologyVon Willebrand factor type A domainPharmacology
23Publications
13H-index
991Citations
Publications 24
Newest
#1Xiaowen Shao (Tongji University)
#2Dandan Wang (Tongji University)H-Index: 3
Last. Lihua Sun (Tongji University)
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Objectives: Early fetal demise (absence of cardiac activity in a visible fetus) is a very common event, but there are no reliable biomarkers to predict it. The purpose of the study was to assess the association of platelet parameters with early fetal demise.Methods: In this case-control study, we included women with normal deliveries or those ultrasound diagnosed as early fetal demise. For those who were identified with early fetal demise, the platelet parameters were analyzed before the ultraso...
Source
#1Dandan Wang (Tongji University)H-Index: 3
Last. Yaozu Xiang (Tongji University)H-Index: 13
view all 9 authors...
Abstract Morbidity and mortality from acute myocardial infarction (AMI) remains substantial although interventional coronary reperfusion strategies are widely use and successful. MI remains the most common cause of heart failure (HF) worldwide. Here we demonstrated that Panax Notoginseng saponins (PNS), the extract of Panax notoginseng, exerts cardioprotective effect in AMI and the underlying mechanism refers to inducing cardiomyocyte autophagy, antiplatelet aggregation, enhancing endothelial mi...
2 CitationsSource
#1Kai Jiang (Tongji University)H-Index: 1
#2Yue Xu (Tongji University)H-Index: 1
Last. Yaozu Xiang (Tongji University)H-Index: 13
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Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular mortality in patients with diabetes mellitus but the protective mechanism remains elusive. Here we demonstrated that the SGLT2 inhibitor, Empagliflozin (EMPA), suppresses cardiomyocytes autosis (autophagic cell death) to confer cardioprotective effects. Using myocardial infarction (MI) mouse models with and without diabetes mellitus, EMPA treatment significantly reduced infarct size, and myocardial fibrosis, thereby leading ...
6 CitationsSource
Cardiovascular disease is the leading cause of death worldwide. In spite of the mature treatments of myocardial ischemia(MI), post-MI reperfusion injury results in high morbidity and mortality. Cardiomyocyte Ca2+ overload is a major factor of I/R injury, initiating a cascade of events contributing to cardiomyocyte death and myocardial dysfunction. Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a critical role in cardiomyocyte death response to I/R injury, whose activation is a key fe...
1 CitationsSource
AIMS: To investigate the characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 (COVID-19). METHODS AND RESULTS: We enrolled 671 eligible hospitalized patients with severe COVID-19 from 1 January to 23 February 2020, with a median age of 63 years. Clinical, laboratory, and treatment data were collected and compared between patients who died and survivors. Risk factors of death and myocardial injury were analysed using multivariable regress...
228 CitationsSource
#1Lan Lin (HAU: Huazhong Agricultural University)H-Index: 8
#2Lei Xu (HAU: Huazhong Agricultural University)H-Index: 1
Last. Anding Zhang (HAU: Huazhong Agricultural University)H-Index: 23
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Infection with the Streptococcus suis (S. suis) epidemic strain can cause Streptococcal toxic shock-like syndrome (STSLS), which is characterized by a cytokine storm, dysfunction of multiple organs and a high incidence of mortality despite adequate treatment. Despite some progress concerning the contribution of the inflammatory response to STSLS, the precise mechanism underlying STSLS development remains elusive. Here, we use a murine model to demonstrate that caspase-1 activity is critical for ...
42 CitationsSource
#1Lei Fu (HAU: Huazhong Agricultural University)H-Index: 10
#2Caiyun Xie (HAU: Huazhong Agricultural University)H-Index: 3
Last. Anding Zhang (HAU: Huazhong Agricultural University)H-Index: 23
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: Argonaute proteins are present and conserved in all domains of life. Recently characterized prokaryotic Argonaute proteins (pAgos) participates in host defense by DNA interference. Here, we report that the Natronobacterium gregoryi Argonaute (NgAgo) enhances gene insertions or deletions in Pasteurella multocida and Escherichia coli at efficiencies of 80-100%. Additionally, the effects are in a homologous arms-dependent but guide DNA- and potential enzyme activity-independent manner. Interestin...
21 CitationsSource
#1Dandan WangH-Index: 3
#2Xiaoyue HuH-Index: 13
Last. Yaozu XiangH-Index: 13
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Highlights •Optimal treatment for patients with diabetes and myocardial infarction remains a challenge. •Hyperglycemia- and hyperinsulinemia-induced miR-24 reduction and O-GlcNAcylation in the diabetic heart contributes to poor survival in diabetic myocardial ischemia reperfusion (I/R) and increased infarct size post-I/R. •Overexpression of miR-24 in murine hearts significantly reduces myocardial infarct size. •miR-24 targets multiple key proteins including O-GlcNac transferase, ATG4A (a key pro...
19 CitationsSource
#1Pei Li (HAU: Huazhong Agricultural University)H-Index: 2
#2Rui Wang (HAU: Huazhong Agricultural University)H-Index: 1
Last. Chen Tan (HAU: Huazhong Agricultural University)H-Index: 19
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Abstract Mycobacterium bovis (M. bovis), the most common pathogens of tuberculosis (TB), is virulent to human and cattle, and transmission between cattle and humans warrants reconsideration concerning food safety and public health. Recently, efforts have begun to analyze cellular proteomic responses induced by Mycobacterium tuberculosis (M. tb). However, the underlying mechanisms by which virulent M. bovis affects human hosts are not fully understood. For the present study, we utilized a global ...
15 CitationsSource
#1Siying ZouH-Index: 5
Last. Diane S. KrauseH-Index: 59
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Leukemia-Associated RhoGEF (LARG) is highly expressed in platelets, which are essential for maintaining normal haemostasis. We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation. Larg KO mice exhibit macrothrombocytopenia, internal bleeding in the ovaries and prolonged bleeding times. KO platelets ...
6 CitationsSource