Xinfeng Yan
Shandong University
Internal medicineEndocrinologyCell migrationGenetically modified mousePathologySingle-nucleotide polymorphismVitamin D-binding proteinMolecular biologyAndrologyCarbohydrate metabolismChemistryMicroarrayInterleukin 10ApoptosisAggrecanIn vitroImmunologyImmunohistochemistryEx vivoAggrecanaseSynovial fluidWestern blotADAMTS4AdiponectinInflammationArthritisAnkylosing spondylitisRheumatoid arthritisSynovial membranePannusPADI4PDK4CD80B cellCytokineCytokeratinCitrullinePADI2Intraperitoneal injectionFibroblastCartilageSpleenCD86Synovial CellSynoviocyte proliferationCell cycleCitrullinationViability assayFlow cytometryMetalloproteinaseCell growthSignal transductionMedicineIntermediate filamentKeratinBlotFibronectinBiologyPharmacology
Publications 10
#1Yange Gu (SDU: Shandong University)
#2Zhiwei Shi (SDU: Shandong University)
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OBJECTIVES To explore factors affecting the efficacy of Bernese periacetabular osteotomy for the treatment of hip dysplasia. METHODS A retrospective study was conducted on 44 patients with hip dysplasia who underwent Bernese periacetabular osteotomy with a modified Smith-Peterson approach between January 2017 and November 2019. Among them, 40 were women and four were men. The average age was 31.2 ± 9.4. Preoperative and postoperative imaging parameters were measured. The acetabular top tilt angl...
Last. Xinfeng Yan (SDU: Shandong University)
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#1Ye-Yong ZhangH-Index: 2
#2Shufeng LiH-Index: 10
Last. Xinfeng YanH-Index: 6
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Aim: This study is to investigate the additive effect of Vitamin D-binding protein (VDBP) and 1,25(OH)2D3 on the viability and apoptosis of synovial cells from patients with rheumatoid arthritis (RA). Methods: Synovial tissues and synovial fluid of patients with RA and osteoarthritis (OA) were collected. The expression of VDBP was analyzed with immunohistochemistry and ELISA. CCK-8 assay was applied to detect cell viability. Flow cytometry was used to analyze cell cycle and apoptosis. Results: I...
#1Huaqiang Sun (SDU: Shandong University)H-Index: 5
#2Dong Yan (SDU: Shandong University)H-Index: 1
Last. Shufeng Li (SDU: Shandong University)H-Index: 10
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An aggressive proliferation of synoviocytes is the hallmark of rheumatoid arthritis (RA). Emerging evidence shows that inhibiting the NF-κB signaling pathway with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] may be a therapeutic approach for controlling inflammatory diseases. In this study, we demonstrated the protective effects of three different 1,25(OH)2D3 concentration on adjuvant-induced arthritis (AA) rats through the NF-κB signaling pathway and their pro-apoptotic roles in cultured adjuvant-ind...
5 CitationsSource
#1Huaqiang Sun (SDU: Shandong University)H-Index: 5
#2Ye-Yong Zhang (SDU: Shandong University)H-Index: 2
Last. Shufeng Li (SDU: Shandong University)H-Index: 10
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Abstract Synovial inflammation is observed in patients with osteoathritis (OA) and likely contributed to its exacerbation. Regulatory B (Breg) cells are shown to suppress inflammation in various diseases, including rheumatoid arthritis (RA). To examine whether Breg cells also participated in OA, we examined the synovial fluid from OA patients, and compared with that in RA patients. In OA synovial fluid, IL-10-producing B cells were present directly ex vivo and were increased upon stimulation, in...
7 CitationsSource
#1Yan Zhao (SDU: Shandong University)H-Index: 3
#2Xinfeng Yan (SDU: Shandong University)H-Index: 6
Last. Xiaotian Chang (SDU: Shandong University)H-Index: 19
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Background Some studies have indicated that glucose metabolism plays an important role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to find the novel genes affecting glucose metabolism in RA.
16 CitationsSource
#1Xiaotian Chang (SDU: Shandong University)H-Index: 19
#2Yifang Xia (SDU: Shandong University)H-Index: 1
Last. Xinfeng Yan (SDU: Shandong University)H-Index: 6
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Citrullination, a posttranslational modification of peptidyl arginine to citrulline, plays an essential role in rheumatoid arthritis (RA). Citrullination is catalyzed by a group of peptidylarginine deiminases (PADs) including PADI 1, 2, 3, 4 and 6. Many studies have indicated that the gene encoding PADI4 is a factor in susceptibility to RA. Some studies have detected PADI2 expression in RA synovial tissues, suggesting that PADI2 also plays an important role in the disease. This study evaluated t...
24 CitationsSource
#1Xinfeng Yan (SDU: Shandong University)H-Index: 6
#2Luxu YinH-Index: 1
Last. Xiaotian ChangH-Index: 19
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OBJECTIVES: Rapid cartilage degradation in the joints is observed in rheumatoid arthritis (RA). ADAMTS4 (a disintegrin and metalloproteinase with thrombospondin motifs-4) degrades aggrecan, the primary component of cartilage, therefore contributing to joint erosion in RA. The proteolytic activity of ADAMTS4 is inhibited by fibronectin (FN). FN is abundantly expressed in the synovia in RA and is modified by citrullination, the conversion of peptidylarginine to citrulline. This study aims to inves...
6 Citations
#1Lin Wang (SDU: Shandong University)H-Index: 19
#2Yabing Zheng (SDU: Shandong University)H-Index: 4
Last. Xiaotian Chang (SDU: Shandong University)H-Index: 19
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Hypoxia stimulates synovial hypoperfusion in rheumatoid arthritis (RA). TXNDC5 stimulates cellular proliferation in hypoxic conditions. We previously detected increased TXNDC5 expression in synovial tissues and blood from RA patients and demonstrated that the gene encoding TXNDC5 increased RA risk. The present study investigated the pathogenic roles of TXNDC5 in RA. Transgenic mice that over-expressed TXNDC5 (TXNDC5-Tg) were generated using C57BL/6J mice and treated with bovine collagen II to in...
23 CitationsSource
#1Xiaotian Chang (Academy of Medical Sciences, United Kingdom)H-Index: 19
#2Xiangdong Jian (SDU: Shandong University)H-Index: 1
Last. Xinfeng YanH-Index: 6
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Keratin is the main component of cellular intermediate filaments, and its post-translational modification plays an important role in cell differentiation and apoptosis, as well as disease states. The conversion of peptidylarginine to citrulline, termed citrullination, is particularly involved in the pathogenesis of rheumatoid arthritis (RA). Immunohistochemistry using an antibody mixture that broadly recognized various keratin forms detected cytokeratin in many cells in the area lining the synov...
12 CitationsSource