Christa Meisinger
Ludwig Maximilian University of Munich
Genome-wide association studyEpidemiologyInternal medicineEndocrinologyDemographyOdds ratioCardiologyCohort studyHazard ratioType 2 diabetesBody mass indexPopulationConfidence intervalMyocardial infarctionRisk factorGeneticsDiabetes mellitusMedicineGerontologyBiology
Publications 666
Summary null Background null Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. null Methods null We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. W...
Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry. These common alleles were associated with clinical extremes of ANM; women in the top 1% of genetic susceptibility have an equivalent risk...
7 CitationsSource
#1Giulia Pestoni (UZH: University of Zurich)H-Index: 6
#2Anna Riedl (LMU: Ludwig Maximilian University of Munich)H-Index: 4
Last. Jakob Linseisen (LMU: Ludwig Maximilian University of Munich)H-Index: 11
view all 12 authors...
Diet is one of the most important modifiable risk factors for the development of type 2 diabetes. Here, we aim to identify dietary patterns and to investigate their association with prediabetes, undetected diabetes and prevalent diabetes. The present study included 1305 participants of the cross-sectional population-based KORA FF4 study. Oral glucose tolerance test (OGTT) measurements together with a physician-confirmed diagnosis allowed for an accurate categorization of the participants accordi...
1 CitationsSource
#1Lena S. Kiefer (University of Tübingen)H-Index: 3
#2Jana Fabian (University of Tübingen)H-Index: 2
Last. Fabian Bamberg (University Medical Center Freiburg)H-Index: 58
view all 16 authors...
AIMS Intramuscular fat contributes to peripheral insulin resistance and type 2 diabetes mellitus (T2DM). Intra- and extramyocellular lipids (IMCLsE prediabetes: 80(23.7%)). IMCLs were significantly higher than EMCLs in subjects without obesity (5.7%(IQR: 4.8-7.0%) vs. 4.1%(IQR: 2.7-5.8%), p<0.001), whereas the amount of IMCLs and EMCLs was shown to be equal and significantly higher in subjects with obesity (both 6.7%, p<0.001). Subjects with prediabetes and T2DM had significantly higher amounts ...
#1Zoheir Alayash (Augsburg College)
#2Michael Nolde (Augsburg College)
Last. Sebastian-Edgar Baumeister (WWU: University of Münster)
view all 5 authors...
Abstract null null Background null Observational studies suggested that cannabis use is associated with decreased body fatness; however, observational studies are subject to confounding, making causal inference and determining the direction of these associations difficult. We performed Mendelian randomization (MR) using summary statistics from genome-wide association studies (GWAS) to investigate the potential causal association of cannabis use and obesity-related traits. null null null Methods ...
#1Marianne Huebner (UHH: University of Hamburg)H-Index: 35
#2Daniela Börnigen (UHH: University of Hamburg)
Last. Martina Müller-NurasyidH-Index: 58
view all 9 authors...
Resettlers are a large migrant group of more than 2 million people in Germany who migrated mainly from the former Soviet Union to Germany after 1989. We sought to compare the distribution of the major risk factors for cardiovascular disease (CVD) and to investigate the overall genetic differences in a study population which consisted of resettlers and native (autochthone) Germans. This was a joint analysis of two cohort studies which were performed in the region of Augsburg, Bavaria, Germany, wi...
#1Alina BauerH-Index: 1
#2Astrid ZiererH-Index: 17
Last. Cornelia HuthH-Index: 35
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It is still unclear how genetic information, provided as single-nucleotide polymorphisms (SNPs), can be most effectively integrated into risk prediction models for coronary heart disease (CHD) to add significant predictive value beyond clinical risk models. For the present study, a population-based case-cohort was used as a trainingset (451 incident cases, 1488 noncases) and an independent cohort as testset (160 incident cases, 2749 noncases). The following strategies to quantify genetic informa...
1 CitationsSource
#1Temur Mamadjanov (LMU: Ludwig Maximilian University of Munich)
#2Konstantinos A. Volaklis (LMU: Ludwig Maximilian University of Munich)H-Index: 17
Last. Christa Meisinger (LMU: Ludwig Maximilian University of Munich)H-Index: 108
view all 10 authors...
STUDY OBJECTIVES To investigate the association between admission blood glucose levels and 28-day mortality as well as in-hospital complications in older patients with incident acute myocardial infarction (AMI) undergoing modern treatment. METHODS From a German population-based regional MI registry, 5530 patients (2016 women), aged 65-84 years, hospitalised with an incident AMI between 1 January 2009 and 31 December 2016 were included in the study. Multivariable logistic regression models were u...
#1Cornelia Then (LMU: Ludwig Maximilian University of Munich)H-Index: 13
#2Christian Herder (HHU: University of Düsseldorf)H-Index: 88
Last. Jochen Seissler (LMU: Ludwig Maximilian University of Munich)H-Index: 30
view all 17 authors...
Analyzing epidemiological data with simplified mathematical models of disease development provides a link between the time-course of incidence and the underlying biological processes. Here we point out that considerable modeling flexibility is gained if the model is solved by simulation only. To this aim, a model of atherosclerosis is proposed: a Markov Chain with continuous state space which represents the coronary artery intimal surface area involved with atherosclerotic lesions of increasing ...
1 CitationsSource