Yeon-Su Lee
New Generation University College
GeneGenome-wide association studyCancerInternal medicineGenotypeOncologySingle-nucleotide polymorphismMolecular biologyOdds ratioRegulation of gene expressionDNA methylationHaplotypeImmunologyLung cancerAdenocarcinomaEpigeneticsCancer researchBreast cancerGeneticsCarcinogenesisBioinformaticsMedicineBiologyCell biologyCancer cell
73Publications
24H-index
1,662Citations
Publications 73
Newest
#1Yeon-Su LeeH-Index: 24
#2Xiaoyong BaoH-Index: 23
Last. Yong Sun LeeH-Index: 3
view all 18 authors...
Interferons (IFNs) are a crucial component in the innate immune response. Especially the IFN-β signaling operates in most cell types and plays a key role in the first line of defense upon pathogen intrusion. The induction of IFN-β should be tightly controlled, because its hyperactivation can lead to tissue damage or autoimmune diseases. Activation of the IFN-β promoter needs Interferon Regulatory Factor 3 (IRF3), together with Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB...
Source
#1Wonkyun Ronny ImH-Index: 2
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. Yong Sun LeeH-Index: 19
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Nc886 is a regulatory non-coding RNA (ncRNA) whose expression is frequently silenced in malignancies. In the case of esophageal squamous cell carcinoma (ESCC), nc886 silencing is associated with shorter survival of patients, suggesting nc886′s tumor suppressor role in ESCC. However, this observation has not been complemented by an in-detail study about nc886′s impact on gene expression and cellular phenotypes. Here we have shown that nc886 inhibits AKT, a key protein in a renowned pro-survival p...
4 CitationsSource
#1Yong Sun LeeH-Index: 3
#1Yong Sun LeeH-Index: 19
Last. Yeon-Su LeeH-Index: 24
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: Protein kinase R (PKR), originally known as an antiviral protein, senses various stresses as well as pathogen-driven double-stranded RNAs. Thereby activated PKR provokes diverse downstream events, including eIF2α phosphorylation and nuclear factor kappa-light-chain-enhancer of activated B cells activation. Consequently, PKR induces apoptosis and inflammation, both of which are highly important in cancer as much as its original antiviral role. Therefore, cellular proteins and RNAs should tightl...
13 CitationsSource
DNA-reactive compounds are harnessed for cancer chemotherapy. Their genotoxic effects are considered to be the main mechanism for the cytotoxicity to date. Because this mechanism preferentially affects actively proliferating cells, it is postulated that the cytotoxicity is specific to cancer cells. Nonetheless, they do harm normal quiescent cells, suggesting that there are other cytotoxic mechanisms to be uncovered. By employing doxorubicin as a representative DNA-reactive compound, we have disc...
7 CitationsSource
#1Ji Hye Ahn (Kyung Hee University)H-Index: 1
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 19
view all 16 authors...
In the original version of the Supplementary Information file associated with this Article, Supplementary Fig. 18 panel b was inadvertently replaced with a duplicate of panel a. The error has now been fixed and the corrected version of the Supplementary Information PDF is available to download from the HTML version of the Article.
1 CitationsSource
#1Daehyeon HanH-Index: 4
#2Young J. KimH-Index: 35
Last. Hyun-Cheol KimH-Index: 21
view all 6 authors...
Source
#1Ji Hye Ahn (Kyung Hee University)H-Index: 1
#2Hyun-Sung Lee (BCM: Baylor College of Medicine)H-Index: 25
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 19
view all 16 authors...
Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subtype of ovarian cancer (OC) that is of poor prognosis. However, the interplay between the two pathways in the OC subtype has not yet been elucidated. nc886 is a recently identified n...
22 CitationsSource
#1Jong Lyul Park (Korea Research Institute of Bioscience and Biotechnology)H-Index: 11
#2Yeon-Su LeeH-Index: 24
Last. Yong Sun LeeH-Index: 19
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RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively ‘Pol III genes’) whose early established biological roles were so essential that they were considered ‘housekeeping genes’. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone mo...
17 CitationsSource
#1Dong Hoon ShinH-Index: 17
#1Dong Hoon ShinH-Index: 3
Last. Ji-Youn HanH-Index: 32
view all 11 authors...
// Dong Hoon Shin 1,5 , Donghoon Lee 2 , Dong Wan Hong 2 , Seung Hyun Hong 2 , Jung-Ah Hwang 2 , Byung Il Lee 3 , Hye Jin You 4 , Geon Kook Lee 1 , In-Hoo Kim 5 , Yeon-Su Lee 2 and Ji-Youn Han 1 1 Lung Cancer Branch, Graduate School of Cancer Science and Policy, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea 2 Cancer Genomic Branch, Graduate School of Cancer Science and Policy, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, Republic of Korea 3 Biom...
26 CitationsSource
#1Eun Kyung LeeH-Index: 18
#2Seung-Hyun HongH-Index: 23
Last. Yong Sun Lee (UTMB: University of Texas Medical Branch)H-Index: 19
view all 15 authors...
// Eun Kyung Lee 1, * , Seung-Hyun Hong 2, * , Sooyong Shin 3, 4, * , Hyun-Sung Lee 5 , Ju-Seog Lee 6 , Eun Jung Park 7, 8 , Sun Shim Choi 9 , Jae Woong Min 9 , Daeyoon Park 1 , Jung-Ah Hwang 2 , Betty H. Johnson 3 , Sung Ho Jeon 4 , In-Hoo Kim 8 , Yeon-Su Lee 2 , Yong Sun Lee 3, 8 1 Center for Thyroid Cancer, National Cancer Center, Goyang, 410-769, Korea 2 Cancer Genomics Branch, Research Institute, National Cancer Center, Goyang, 410-769, Korea 3 Department of Biochemistry and Molecular Biolo...
19 CitationsSource