Xun Sun
Sichuan University
PharmacokineticsBiophysicsGene deliveryAntigenMolecular biologyLiposomeChemistryMaterials scienceIn vitroImmunologyIn vivoDrug deliveryChromatographyCancer researchTransfectionBiochemistryMedicineBiologyImmune systemPharmacology
206Publications
50H-index
5,137Citations
Publications 212
Newest
#1Xiaoyan Chen (Sichuan University)H-Index: 2
#2Guangsheng Du (Sichuan University)H-Index: 7
Last. Yao Fu (Sichuan University)H-Index: 27
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Abstract null null Promoted tolerance is a coveted therapeutic approach for rheumatoid arthritis (RA), as current immunosuppressive treatments are not disease-specific, primarily targeting the inflammatory response and exerting debilitating side effects. The cellular and antigenic complexity of RA challenges the design of nanoparticle-based tolerogenic strategies to selectively and comprehensively ameliorate joint destruction and restore immune tolerance in RA. Herein, we aimed at exploring the ...
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#1Yuai Li (Sichuan University)
#2Lan Yang (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Size expansion can effectively improve tumor accumulation of nanocarriers where precise control is required. A dual-responsive nanocarrier stimulated by both endogenous pH and exogenous heat stimuli can change its size. Herein, a nanoparticle composed of poly(N,N-diethyl acrylamide) (PDEAA) and poly(2-(diisopropylamino) ethyl methacrylate) (PDPA) is developed. The antitumor drug celastrol (CLT) and the photosensitizer indocyanine green (ICG) are then loaded in it to form CIPP. ICG generates heat...
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#1Yicong Zhang (Sichuan University)H-Index: 1
#2Yuai Li (Sichuan University)
Last. Ling Zhang (Sichuan University)H-Index: 9
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Metastasis is a major sign of malignant tumors which plays a vital role in cancer-related death. Suppressing metastasis is an important way to improve the survival rate of cancer patients. Herein, multifunctional PEG-LAM-PPS nanoparticles (nPLPs) are fabricated as both nanocarriers and anti-metastatic agents for tumor treatment. In this system, laminarin sulfate (LAM) suppresses metastasis by reducing heparinase and protecting the extracellular matrix; the ROS-sensitive polypropylene sulfide (PP...
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#1Yuan dong Zhang (Zunyi Medical College)
#2Man Li (Sichuan University)
Last. Xun Sun (Sichuan University)H-Index: 50
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Abstract null null Infectious diseases continue to inflict a high global disease burden. The consensus is that vaccination is the most effective option against infectious diseases. Oral vaccines have unique advantages in the prevention of global pandemics due to their ease of use, high compliance, low cost, and the ability to induce both systemic and mucosal immune responses. However, challenges of adapting vaccines for oral administration remain significant. Foremost among these are enzymatic a...
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#1Guangsheng Du (Sichuan University)H-Index: 7
#2Penghui He (Sichuan University)H-Index: 1
Last. Xun Sun (Sichuan University)H-Index: 50
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Abstract null null Transdermal drug delivery systems for rheumatoid arthritis (RA) have been receiving increasing attention as they can potentially overcome drawbacks which exist in traditional oral or injection strategies, including low patient compliance and serious gastrointestinal side effects. However, transdermal delivery of RA drugs especially biological drugs suffers from low drug delivery efficiency due to the robust skin barrier. Herein, we fabricated melittin-loaded hyaluronic acid (H...
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Abstract null null Current clinical agents for autoimmunity disorders treatment often cause substantial adverse effects and safety concerns, owing to non-specific immune modulation. Due to the prominent contribution of effector T cells in pathogenesis of rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), and preferential location of co-stimulatory receptor-ligand pair OX40-OX40L at the inflamed sites, selectively targeting autoaggressive T cells by blockade OX40-OX40L, might represe...
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#1Xinyan Hao (Sichuan University)H-Index: 1
#2Yuandong Zhang (Sichuan University)H-Index: 4
Last. Xun Sun (Sichuan University)H-Index: 50
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Objective To prepare a chitosan-modified cationic nanoemulsion that could be used to prolong the residence time of nasal vaccines in the nasal cavity and improve the cellular uptake efficiency so as to enhance the immune efficacy of nasal vaccines. Methods A nanoemulsion-based vaccine coated with chitosan was prepared, and the particle size, potential, antigen encapsulation efficiency, stability as well as cytotoxicity were examined. The uptake efficiency of vaccine on different cells and the re...
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#1Shiqi Huang (Sichuan University)H-Index: 4
#2Lang Deng (Sichuan University)H-Index: 3
Last. Ling Zhang (Sichuan University)H-Index: 9
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Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung, leading to sharply reduced patients’ survival rate. Effectively treating these tumors thus could improve late stage melanoma with lung metastasis. In this study, we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu (CR(NMe)EKA) decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and paclitaxel (PTX) to lung melanoma tumor sites (TRAIL-[ND-PTX]C...
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#1Y.P. Hou (Sichuan University)H-Index: 6
#2Rong Liu (Sichuan University)H-Index: 9
Last. Xun Sun (Sichuan University)H-Index: 50
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Sustained release vaccine carriers can facilitate an increased interaction time between the antigen and immune system to strengthen immune responses, but their promotion on adaptive immune responses, especially cellular immunity, are still unfavorable. Herein, we report a sustained antigen delivery vector, which carries abundant antigens, a nucleic acid adjuvant and pathogen-associated molecular patterns to simulate a natural pathogen to reinforce immune responses. Specifically, murine colorecta...
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#1Xiaoyan Chen (Sichuan University)H-Index: 2
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