Atta Behfar
Mayo Clinic
Regenerative medicineInternal medicineSurgeryEmbryonic stem cellCardiologyRegeneration (biology)Intensive care medicineHemodynamicsMesenchymal stem cellImmunologyAdult stem cellHeart failureVentricular assist deviceStem-cell therapyStem cellIn patientMyocardial infarctionClinical trialMedicineBiologyCell biology
Publications 183
#1Satsuki Yamada (Mayo Clinic)H-Index: 23
#2Ryoung-Hoon Jeon (Mayo Clinic)H-Index: 10
Last. Andre Terzic (Mayo Clinic)H-Index: 97
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Risk of outcome variability challenges therapeutic innovation. Selection of the most suitable candidates is predicated on reliable response indicators. Especially for emergent regenerative biotherapies, determinants separating success from failure in achieving disease rescue remain largely unknown. Accordingly, (pre)clinical development programs have placed increased emphasis on the multi-dimensional decoding of repair capacity and disease resolution, attributes defining responsiveness. To attai...
#1Akira Ikumi (Mayo Clinic)
#2Anne Gingery (Mayo Clinic)H-Index: 15
Last. Soulmaz BoroumandH-Index: 2
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BACKGROUND The nerve autograft remains the gold standard when reconstructing peripheral nerve defects. However, although autograft repair can result in useful functional recovery, poor outcomes are common, and better treatments are needed. The purpose of this study was to evaluate the effect of purified exosome product on functional motor recovery and nerve-related gene expression in a rat sciatic nerve reverse autograft model. METHODS Ninety-six Sprague-Dawley rats were divided into three exper...
#1Vinayak Kumar (Mayo Clinic)H-Index: 3
#2Armando Manduca (Mayo Clinic)H-Index: 59
Last. Nandan S. Anavekar (Mayo Clinic)H-Index: 25
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BACKGROUND Myocardial volume is assumed to be constant over the cardiac cycle in the echocardiographic models used by professional guidelines, despite evidence that suggests otherwise. The aim of this paper is to use literature-derived myocardial strain values from healthy patients to determine if myocardial volume changes during the cardiac cycle. METHODS A systematic review for studies with longitudinal, radial, and circumferential strain from echocardiography in healthy volunteers ultimately ...
#1D. Kent Arrell (Mayo Clinic)H-Index: 18
Last. Andre Terzic (Mayo Clinic)H-Index: 97
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Stem cell paracrine activity is implicated in cardiac repair. Linkage between secretome functionality and therapeutic outcome was here interrogated by systems analytics of biobanked human cardiopoietic cells, a regenerative biologic in advanced clinical trials. Protein chip array identified 155 proteins differentially secreted by cardiopoietic cells with clinical benefit, expanded into a 520 node network, collectively revealing inherent vasculogenic properties along with cardiac and smooth muscl...
#1Andrew N. RosenbaumH-Index: 10
#2Bradley TernusH-Index: 6
Last. Jacob C. JentzerH-Index: 21
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#1Ao ShiH-Index: 1
#2Jialun LiH-Index: 1
Last. Steven L. MoranH-Index: 58
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Rationale: With over seven million infections and $25 billion treatment cost, chronic ischemic wounds are one of the most serious complications in the United States. The controlled release of bioactive factor enriched exosome from finbrin gel was a promising strategy to promote wound healing. Methods: To address this unsolved problem, we developed clinical-grade platelets exosome product (PEP), which was incorporate with injectable surgical fibrin sealant (TISSEEL), to promote chronic wound heal...
#1Michael S. Sabbah (Mayo Clinic)H-Index: 1
#2Andrew N. Rosenbaum (Mayo Clinic)H-Index: 10
Last. Atta Behfar (Mayo Clinic)H-Index: 37
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Purpose Although hemodynamic status prior to continuous flow left ventricular assist device placement (CF-LVAD) is an important determinant of outcomes, data on pre-implant optimization and patient-oriented outcomes are sparse. Methods We identified consecutive patients undergoing CF-LVAD implant between 2007 and 2017 at a single institution. Hemodynamic variables at three time points and laboratory studies were evaluated pre-LVAD implant in a logistic regression model to identify predictors of ...