Jae Woong Han
Konkuk University
CytotoxicityDynamic light scatteringNanoparticleFourier transform infrared spectroscopyNanotechnologyChemistryReducing agentApoptosisMaterials scienceImmunologyBiocompatibilityOxideGrapheneSilver nanoparticleRaman spectroscopyReactive oxygen speciesViability assayBiochemistryBiologyCell biologyCancer cell
30Publications
24H-index
2,372Citations
Publications 30
Newest
#1Jae Woong Han (Konkuk University)H-Index: 24
#2Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 4 authors...
BACKGROUND: Silver nanoparticles (AgNPs) exhibit strong antibacterial and anticancer activity owing to their large surface-to-volume ratios and crystallographic surface structure. Owing to their various applications, understanding the mechanisms of action, biological interactions, potential toxicity, and beneficial effects of AgNPs is important. Here, we investigated the toxicity and differentiation-inducing effects of AgNPs in teratocarcinoma stem cells. MATERIALS AND METHODS: AgNPs were synthe...
16 CitationsSource
#1Joydeep Das (Konkuk University)H-Index: 34
#1Joydeep Das (Konkuk University)H-Index: 10
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 5 authors...
Nanocarriers are widely used for effective delivery of anticancer drugs to tumours with potential to improve cancer treatment. Here, we developed a nanoceria (CeO2)-based system for delivery of the anti-cancer drug doxorubicin (DOX) to human ovarian cancer cells. Negatively charged nanoceria could conjugate with the cationic DOX via electrostatic interaction under physiological conditions, forming DOX-loaded nanoceria (CeO2/DOX). CeO2/DOX particles displayed nearly spherical shapes, along with s...
28 CitationsSource
#1Jung Hyun Park (Konkuk University)H-Index: 13
#2Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
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Abstract Silver nanoparticles (AgNPs) are used as cytotoxic agents in various cancer cell lines; however, the cytotoxic effects of AgNPs on human neuroblastoma cells remain poorly understood. Here we report the mechanisms of action of AgNPs on brain-derived neurotrophic factor (BDNF) activation in human neuroblastoma cells using AgNPs. The results from biochemical, cellular and western blot analysis indicated that AgNPs significantly inhibit BDNF induced cell survival by enhanced leakage of lact...
14 CitationsSource
#1Yun-Jung Choi (Konkuk University)H-Index: 25
#2Jung Hyun Park (Konkuk University)H-Index: 13
Last. Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
view all 8 authors...
The cancer stem cell (CSC) hypothesis postulates that cancer cells are composed of hierarchically-organized subpopulations of cells with distinct phenotypes and tumorigenic capacities. As a result, CSCs have been suggested as a source of disease recurrence. Recently, silver nanoparticles (AgNPs) have been used as antimicrobial, disinfectant, and antitumor agents. However, there is no study reporting the effects of AgNPs on ovarian cancer stem cells (OvCSCs). In this study, we investigated the cy...
19 CitationsSource
#2Jung Hyun ParkH-Index: 13
Last. Jin-Hoi KimH-Index: 60
view all 5 authors...
7 CitationsSource
#1Joydeep Das (Konkuk University)H-Index: 34
#1Joydeep Das (Konkuk University)H-Index: 10
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 8 authors...
Efficient delivery of C/EBP beta gene into human mesenchymal stem cells via polyethylenimine-coated gold nanoparticles enhances adipogenic differentiation
22 CitationsSource
#1Joydeep Das (Konkuk University)H-Index: 34
#1Joydeep Das (Konkuk University)H-Index: 10
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 8 authors...
Cationic lipid-nanoceria hybrids, a novel nonviral vector-mediated gene delivery into mammalian cells: investigation of the cellular uptake mechanism
25 CitationsSource
#1Jae-Kyo Jeong (Konkuk University)H-Index: 5
#2Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
Last. Jin-Hoi KimH-Index: 60
view all 12 authors...
Solid tumors are frequently associated with resistance to chemotherapy because the fraction of hypoxic tumor cells is substantial. To understand the underlying mechanism of hypoxia on silver nanoparticle (AgNPs)-induced apoptosis, the expression of hypoxia-inducible factor (HIF)-1α, a hallmark of hypoxia, was measured in the presence and absence of AgNPs. The results showed that HIF-1α expression was upregulated after AgNPs treatment under both hypoxic and normoxic conditions. Cell viability ass...
45 CitationsSource
#1Jae Woong Han (Konkuk University)H-Index: 24
#2Jae-Kyo Jeong (Konkuk University)H-Index: 5
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 11 authors...
AbstractSilver nanoparticles (AgNPs) are widely used as an antibiotic agent in textiles, wound dressings, medical devices, and appliances such as refrigerators and washing machines. The increasing use of AgNPs has raised concerns about their potential risks to human health. Therefore, this study was aimed to determine the impact of AgNPs in germ cell specific complications in mice. The administration of AgNPs results in toxicity in mice; however, a more detailed understanding of the effects of A...
43 CitationsSource
#1Sangiliyandi Gurunathan (Konkuk University)H-Index: 60
#2Eunsu Kim (Konkuk University)H-Index: 7
Last. Jin-Hoi Kim (Konkuk University)H-Index: 60
view all 5 authors...
The purpose of this study was to design and synthesize Palladium nanoparticles (PdNPs) using an environmentally friendly approach and evaluate the in vitro efficacy of PdNPs in human ovarian cancer A2780 cells. Ultraviolet-Visible (UV-Vis) spectroscopy was used to monitor the conversion of Pd(II) ions to Pd(0)NPs. X-ray diffraction (XRD) revealed the crystallinity of the as-synthesized PdNPs and Fourier transform infrared spectroscopy (FTIR) further confirmed the role of the leaf extract of Evol...
47 CitationsSource