Ziyuan Li
Sichuan University
Cleavage (embryo)Medicinal chemistryCatalysisHeck reactionOrganic chemistryChemistryCombinatorial chemistryFunctional groupOxazoleThiazoleAlkylRing (chemistry)ArylN-fluorobenzenesulfonimideC h bondBond cleavageCoupling (electronics)PalladiumCopperOxidative phosphorylationStereochemistryLigand
37Publications
11H-index
390Citations
Publications 24
Newest
#1Dong Yang (Sichuan University)H-Index: 1
#2Jingqi Shi (Sichuan University)
Last. Ziyuan Li (Sichuan University)H-Index: 11
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Employing sulfonyl azide as a nitrogen donor, a visible-light-enabled aerobic dealkylative imidation of tertiary and secondary amines involving C(sp3)–C(sp3) bond cleavage with moderate to excellent yields at room temperature is described. It has been demonstrated that this imidation could take place spontaneously upon visible-light irradiation, and could be facilitated considerably by a ruthenium photocatalyst and oxygen. An alternative mechanism to the previous aerobic photoredox pathway has a...
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#1Chuanhai Wu (Sichuan University)H-Index: 2
#2Yan-bei Tu (Sichuan University)H-Index: 1
Last. Yanfang Li (Sichuan University)H-Index: 1
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Abstract This current study described the design and synthesis of a series of derivatives based on a natural pyranoisaflavone, which was obtained from the seeds of Millettia pachycarpa and displayed attractive BChE inhibition and high selectivity in our previous study. The inhibitory potential of all derivatives against two cholinesterases was evaluated. Only a few compounds demonstrated AChE inhibitory activity at the tested concentrations, while 26 compounds showed significant inhibition on BC...
3 CitationsSource
#1Qi Miao (Sichuan University)H-Index: 3
#2Zhong Shao (Sichuan University)H-Index: 1
Last. Ziyuan Li (Sichuan University)H-Index: 11
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A TEMPO-catalysed direct amination of arene through C–H bond cleavage employing N-fluorobenzenesulfonimide (NFSI) as the amination reagent in good to excellent yields with broad arene scope in the absence of any metal, ligand or additive is reported. Unlike previous transition metal-catalysed aminations in which high reaction temperatures are usually necessary, this novel reaction at room temperature is the first example of C–H amination with NFSI that is realised via organocatalysis. The probab...
6 CitationsSource
#1Cuiying Shi (Sichuan University)H-Index: 2
#2Qi Miao (Sichuan University)H-Index: 3
Last. Ziyuan Li (Sichuan University)H-Index: 11
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2 CitationsSource
#1Bowen Lei (Sichuan University)H-Index: 6
#2Qi Miao (Sichuan University)H-Index: 3
Last. Ziyuan Li (Sichuan University)H-Index: 11
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A novel efficient metal-free aminoiodination of alkenes with N-fluorobenzenesulfonimide (NFSI) through an iodonium intermediate under mild conditions with good regioselectivity and stereoselectivity is reported. Unlike transition-metal catalysed aminative bisfunctionalization with NFSI in which the oxidative addition of NFSI to transition-metals affords an electrophilic amino radical, the oxidation of anionic iodide by NFSI in situ generates an electrophilic iodine cation and an amino nucleophil...
4 CitationsSource
#1Lun Wang (Sichuan University)H-Index: 3
#2Huan Tang (Sichuan University)H-Index: 8
Last. Ziyuan Li (Sichuan University)H-Index: 11
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Abstract Two new triterpenoids, named as 3 β -( E )- p -caffeoylnepeticin ( 1 ) and 3 β -( E )-3,4-dimethoxycinnamate-20( S )-dammarenediol II ( 2 ), along with three known compounds 3 , 4 and 5 were isolated from the stems of Celastrus orbiculatus Thunb. The structures of these compounds were elucidated by spectroscopic methods including IR, 1D and 2D NMR as well as by high-resolution mass spectrometric analysis. The anti-inflammatory activities and the cytotoxic effects were evaluated on lipop...
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#1Bowen Lei (Sichuan University)H-Index: 6
#2Xiaojiao Wang (Sichuan University)H-Index: 5
Last. Ziyuan Li (Sichuan University)H-Index: 11
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An iron-catalysed intermolecular vicinal aminoazidation of alkenes, using N-fluorobenzenesulfonimide (NFSI) and trimethylsilyl azide (TMSN3) as the imidating and azidating reagents respectively, is described, which could potentially provide a valuable route toward diverse vicinal diamine derivatives of great significance in medicinal chemistry and organic synthesis. Such iron-catalysed aminative bisfunctionalization of alkene with NFSI has not yet been reported before. Comparing to previously em...
5 CitationsSource
#1Xiaojiao Wang (Sichuan University)H-Index: 5
#2Bowen Lei (Sichuan University)H-Index: 6
Last. Ziyuan Li (Sichuan University)H-Index: 11
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An iron(II)-catalyzed direct imidation of oxazole and thiazole with N-fluorobenzenesulfonimide (NFSI) through C(5)−H bond cleavage is disclosed, providing C5-imidated azoles in moderate to excellent yields with broad substrate scope. This reaction represents the first iron-catalyzed C−H imidation of arene where NFSI serves as the imidation reagent, and potentially constitutes an efficient access to C5-functionalized azole with great medicinal significance.
8 CitationsSource
#1Xiaojiao Wang (Sichuan University)H-Index: 5
#2Bowen Lei (Sichuan University)H-Index: 6
Last. Ziyuan Li (Sichuan University)H-Index: 11
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Direct C5-alkylation of oxazole/thiazole with ether or cycloalkane has been achieved through a cobalt-catalyzed cross-dehydrogenative coupling (CDC) process in moderate to good yields. This transformation represents the first C(sp2)−C(sp3) cross-coupling at the C5-position of the oxazole/thiazole via double C−H bond cleavages. Various functional groups on oxazole/thiazole substrates, as well as water and air, are well-tolerated with this concise and practical protocol, constituting straightforwa...
15 CitationsSource
#1Ziyuan Li (PKU: Peking University)H-Index: 11
#2Xiaoyang Wang (PKU: Peking University)H-Index: 12
Last. Ning Jiao (PKU: Peking University)H-Index: 74
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A concise and efficient aerobic oxidation and oxygenation approach for the construction of 2-aroylquinolines has been developed through copper-catalyzed annulation of anilines, acetaldehydes, and dioxygen. 2,2,6,6-Tetramethylpiperidine-1-oxyl was employed to direct the selectivity toward the desired 2-aroyl products. Molecular oxygen was used in this transformation as an environmentally benign source of oxygen.
7 CitationsSource