Owen Vaughan
Anschutz Medical Campus
OffspringInternal medicinePhenotypeEndocrinologyGlucose transporterAndrologyFetusIn uteroPlacentaTrophoblastPregnancyInsulinHypoxia (medical)CorticosteroneGlucocorticoidAmino acidMedicineBiology
67Publications
22H-index
1,542Citations
Publications 49
Newest
#1Katie L. Davies (University of Cambridge)H-Index: 3
#2Emily J. Camm (Hudson Institute of Medical Research)H-Index: 21
Last. AL Fowden (University of Cambridge)H-Index: 8
view all 7 authors...
In adults, glucocorticoids act to match the supply and demand for energy during physiological challenges, partly through actions on tissue mitochondrial oxidative phosphorylation (OXPHOS) capacity. However, little is known about the role of the natural prepartum rise in fetal glucocorticoid concentrations in preparing tissues for the increased postnatal energy demands. This study examined the effect of manipulating cortisol concentrations in fetal sheep during late gestation on mitochondrial OXP...
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#1Owen Vaughan (UCL: University College London)H-Index: 22
#2Katarzyna Maksym (UCL: University College London)H-Index: 2
Last. Fredrick J. Rosario (Anschutz Medical Campus)H-Index: 19
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Fetal growth restriction (FGR) is a complication of pregnancy that reduces birth weight, markedly increases infant mortality and morbidity and is associated with later-life cardiometabolic disease. No specific treatment is available for FGR. Placentas of human FGR infants have low abundance of sodium-coupled neutral amino acid transporter 2 (Slc38a2/SNAT2), which supplies the fetus with amino acids required for growth. We determined the mechanistic role of placental Slc38a2/SNAT2 deficiency in t...
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#1Owen Vaughan (Anschutz Medical Campus)H-Index: 22
#2Fredrick J. Rosario (Anschutz Medical Campus)H-Index: 19
Last. Thomas Jansson (Anschutz Medical Campus)H-Index: 61
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Obesity in pregnant women causes fetal cardiac dysfunction and increases offspring cardiovascular disease risk but its effect on myocardial metabolism is unknown. We hypothesised that maternal obesity alters fetal cardiac expression of metabolism-related genes and shifts offspring myocardial substrate preference from glucose towards lipids. Female mice were fed control or obesogenic diets before and during pregnancy. Fetal hearts were studied in late gestation (embryonic day, E18.5; term{approx}...
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#2J. S. HigginsH-Index: 4
Last. Amanda N. Sferruzzi-PerriH-Index: 30
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#1Jonas ZauggH-Index: 3
Last. Christiane AlbrechtH-Index: 27
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#1Owen Vaughan (Anschutz Medical Campus)H-Index: 22
#2Fredrick J. Rosario (Anschutz Medical Campus)H-Index: 19
Last. Thomas Jansson (Anschutz Medical Campus)H-Index: 61
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Adiponectin concentrations are low in obese pregnant women. Restoring normal adiponectin concentrations by infusion in obese pregnant mice prevents placental dysfunction, foetal overgrowth and metabolic syndrome in the offspring. We hypothesised that normalising maternal adiponectin in obese late pregnant dams prevents cardiac dysfunction in the adult offspring. Pregnant female mice with diet-induced obesity were infused with adiponectin (0.62 μg g−1 day−1, n = 24) or saline (n = 22) over days 1...
12 CitationsSource
#1Owen Vaughan (Anschutz Medical Campus)H-Index: 22
#2Fredrick Thompson (Anschutz Medical Campus)H-Index: 1
Last. Thomas Jansson (Anschutz Medical Campus)H-Index: 61
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Women residing at high altitude deliver infants of lower birth weight than at sea-level. Birth weight correlates with placental System A-mediated amino acid transport capacity and severe environmen...
4 CitationsSource
#1Owen Vaughan (Anschutz Medical Campus)H-Index: 22
#2Theresa L. Powell (Anschutz Medical Campus)H-Index: 66
Last. Thomas Jansson (Anschutz Medical Campus)H-Index: 61
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: Excess maternal glucocorticoids reduce placental amino acid transport and fetal growth, but whether these effects are mediated directly on the syncytiotrophoblast remains unknown. We hypothesised that glucocorticoids inhibit mechanistic target of rapamycin (mTOR) signaling and insulin-stimulated System A amino acid transport activity in primary human trophoblast (PHT) cells. Syncytialised PHTs, isolated from term placentas (n = 15), were treated with either cortisol (1 μM) or dexamethasone (1 ...
3 CitationsSource
#1Owen Vaughan (Anschutz Medical Campus)H-Index: 22
#2Theresa L. Powell (Anschutz Medical Campus)H-Index: 66
Last. Thomas Jansson (Anschutz Medical Campus)H-Index: 61
view all 3 authors...
Apelin is an insulin-sensitizing hormone increased in abundance with obesity. Apelin and its receptor, APJ, are expressed in the human placenta, but whether apelin regulates placental function in n...
9 CitationsSource
#1Amanda N. Sferruzzi-Perri (University of Cambridge)H-Index: 30
#2J. S. Higgins (University of Cambridge)H-Index: 4
Last. Abigail L. Fowden (University of Cambridge)H-Index: 71
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Mitochondria respond to a range of stimuli and function in energy production and redox homeostasis. However, little is known about the developmental and environmental control of mitochondria in the placenta, an organ vital for fetal growth and pregnancy maintenance in eutherian mammals. Using respirometry and molecular analyses, the present study examined mitochondrial function in the distinct transport and endocrine zones of the mouse placenta during normal pregnancy and maternal inhalation hyp...
41 CitationsSource