Tatsuji Hasegawa
Kyoto Prefectural University of Medicine
Internal medicineEndocrinologyMagnetic resonance imagingDiffusion MRICardiologyPediatricsMonoamine neurotransmitterSerotoninSpleniumGestational ageMECP2Intraventricular hemorrhageCerebral palsyCerebellumSuperior cerebellar peduncleWhite matterEffective diffusion coefficientMedicineTractographyBiologyFractional anisotropy
14Publications
7H-index
145Citations
Publications 14
Newest
#1Satoshi Sakaue (Kyoto Prefectural University of Medicine)H-Index: 2
#2Tatsuji Hasegawa (Kyoto Prefectural University of Medicine)H-Index: 7
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 9 authors...
BACKGROUND Few studies have examined the effect of low-grade intraventricular hemorrhage (IVH) on the white matter in the cerebellum and its association with neurodevelopment. We evaluated cerebellar white matter at term-equivalent age (TEA) in preterm infants with low-grade IVH. Furthermore, we assessed neurodevelopmental outcomes at three years of age to examine the influence of low-grade IVH on neurodevelopment. METHODS Thirteen infants with low-grade IVH and 26 without IVH, born at <30 weeks...
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#1Kanae Hashiguchi (Kyoto Prefectural University of Medicine)H-Index: 2
#2Nagato Kuriyama (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime HosoiH-Index: 33
view all 15 authors...
BACKGROUND: The process of birth causes stress for neonates, but additional stressors for sick neonates are of concern. As analysis of heart rate variability (HRV), which reflects autonomic activity, has demonstrated that low-frequency (LF) activity reflects overall autonomic activity, high-frequency (HF) activity reflects parasympathetic activity, and the LF/HF ratio reflects sympathetic activity, HRV has been clinically applied as a non-invasive index of physical stress. In this study, we eval...
1 CitationsSource
#1Akari Takai (Kyoto Prefectural University of Medicine)H-Index: 2
#2Tatsuji Hasegawa (Kyoto Prefectural University of Medicine)H-Index: 7
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 5 authors...
A 613 g girl was born at 23 weeks of gestation by vaginal delivery due to maternal chorioamnionitis. She developed constipation and abdominal distention on day 2, a small amount of peritoneal fluid and low blood pressure on day 4 and bloody stool on day 6. Abdominal X-ray showed a non-specific bowel gas pattern. Necrotising enterocolitis (NEC) was suspected and treated by fasting, vasopressor support …
1 CitationsSource
#1Tatsuji Hasegawa (Kyoto Prefectural University of Medicine)H-Index: 7
#2Kei Yamada (Kyoto Prefectural University of Medicine)H-Index: 45
Last. Masafumi Morimoto (Kyoto Prefectural University of Medicine)H-Index: 21
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Abstract Purpose Cerebellar injury is well established as an important finding in preterm infants with cerebral palsy (CP). In this study, we investigated associations between injury to the cerebellar peduncles and motor impairments in preterm infants using quantitative tractography at term-equivalent age, which represents an early phase before the onset of motor impairments. Methods We studied 64 preterm infants who were born at Results The infants in the CP group had significantly lower FA of ...
2 CitationsSource
#1Akari Takai (Kyoto Prefectural University of Medicine)H-Index: 2
#2Tomoko Iehara (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 10 authors...
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#1Masashi Zuiki (Kyoto Prefectural University of Medicine)H-Index: 4
#2Tomohiro Chiyonobu (Kyoto Prefectural University of Medicine)H-Index: 16
Last. Masafumi Morimoto (Kyoto Prefectural University of Medicine)H-Index: 5
view all 12 authors...
Abstract Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, prenatal exposure to interleukin-6 (IL-6) has been associated with behavioral and neuropathological abnormalities, though such findings remain to be elucidated in humans. We ...
8 CitationsSource
#1Satoshi Kidowaki (Kyoto Prefectural University of Medicine)H-Index: 5
#2Masafumi Morimoto (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 12 authors...
Abstract Purpose We used diffusion tensor imaging (DTI) to evaluate longitudinal changes in fractional anisotropy (FA) of white matter tracts in preterm infants without abnormal magnetic resonance imaging (MRI) findings. Imaging was conducted at term equivalent age (TEA) and 1 year of corrected age. Furthermore, we assessed correlations between FA and neurodevelopmental outcomes at 3 years of corrected age to investigate brain prematurity of preterm infants without MRI abnormalities. Methods Pre...
6 CitationsSource
#1Takashi Morita (Kyoto Prefectural University of Medicine)H-Index: 5
#2Masafumi Morimoto (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 12 authors...
Introduction Recent diffusion tensor imaging (DTI) studies have demonstrated that leakage of hemosiderin into cerebrospinal fluid (CSF), which is caused by high-grade intraventricular hemorrhage (IVH), can affect cerebellar development in preterm born infants. However, a direct effect of low-grade IVH on cerebellar development is unknown. Thus, we evaluated the cerebellar and cerebral white matter (WM) of preterm infants with low-grade IVH.
28 CitationsSource
#1Masaharu Moroto (Kyoto Prefectural University of Medicine)H-Index: 4
#2Akira Nishimura (Kyoto Prefectural University of Medicine)H-Index: 24
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
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Abstract Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein 2 (MeCP2) gene. In previous studies, monoaminergic dysfunctions have been detected in patients with RTT and in a murine model of RTT, the Mecp2 -null mouse. Therefore, the pathogenesis of RTT is thought to involve impairments in the monoaminergic systems. However, there have been limited data showing that the impairment of monoamines leads to early symptoms during development. We u...
6 CitationsSource
#1S. Morioka (Kyoto Prefectural University of Medicine)H-Index: 6
#2Masafumi Morimoto (Kyoto Prefectural University of Medicine)H-Index: 21
Last. Hajime Hosoi (Kyoto Prefectural University of Medicine)H-Index: 33
view all 12 authors...
Introduction With reducing mortality in children with hematological malignancies, the survivors' quality of life regarding development of chronic neurological disturbances is important. We aimed to determine whether chemotherapy affects white matter (WM).
21 CitationsSource