Ruben C. Gur
University of Pennsylvania
PsychiatryPsychopathologyInternal medicineDevelopmental psychologyNeuropsychologyPsychologyNeuroscienceCognitionNeurocognitiveCognitive psychologyFacial expressionSchizophrenia (object-oriented programming)Functional magnetic resonance imagingPsychosisComputer scienceAudiologyNeuroimagingClinical psychologyMedicineSchizophrenia
Publications 820
#1Anissa Abi-DarghamH-Index: 85
#2Jonathan A. Javitch (Columbia University)H-Index: 104
Last. Raquel E. Gur (UPenn: University of Pennsylvania)H-Index: 142
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Decades of research have highlighted the importance of optimal stimulation of cortical dopaminergic receptors, particularly the D1R receptor (D1R), for prefrontal-mediated cognition. This mechanism is particularly relevant to the cognitive deficits in schizophrenia, given the abnormalities in cortical dopamine (DA) neurotransmission and in the expression of D1R. Despite the critical need for D1R-based therapeutics, many factors have complicated their development and prevented this important ther...
#1Kristin Murtha (UPenn: University of Pennsylvania)H-Index: 2
#2Bart Larsen (UPenn: University of Pennsylvania)H-Index: 12
Last. Martin A. Lindquist (Johns Hopkins University)H-Index: 43
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Low socioeconomic status has been shown to have detrimental effects on cognitive performance, including working memory (WM). As executive systems that support WM undergo functional neurodevelopment during adolescence, environmental stressors at both individual and community levels may have a particularly strong impact on cognitive outcomes. Here, we sought to examine how neighborhood socioeconomic status (SES) impacts task-related activation of the executive system during adolescence, and to det...
#1Aaron Alexander-Bloch (UPenn: University of Pennsylvania)H-Index: 27
#2Rahul Sood (UPenn: University of Pennsylvania)
Last. Raquel E. Gur (UPenn: University of Pennsylvania)H-Index: 142
view all 11 authors...
Abstract null null Background null Obsessive compulsive symptomatology (OCS) is common in adolescence but usually does not meet the diagnostic threshold for obsessive compulsive disorder. Nevertheless, both OCD and subthreshold OCS are associated with increased likelihood of experiencing other serious psychiatric conditions including depression and suicidal ideation. Unfortunately, there is limited information on the neurobiology of OCS. null null null Methods null Here we undertook one of the f...
#1Zaixu Cui (UPenn: University of Pennsylvania)H-Index: 15
#2Adam Pines (UPenn: University of Pennsylvania)H-Index: 6
Last. Monica E. Calkins (UPenn: University of Pennsylvania)H-Index: 62
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The spatial layout of large-scale functional brain networks differs between individuals and is particularly variable in association cortex that has been implicated in a broad range of psychiatric disorders. However, it remains unknown whether this variation in functional topography is related to major dimensions of psychopathology in youth. Capitalizing on a large sample with 27-minutes of high-quality functional MRI data (n=790, ages 8-23 years) and advances in machine learning, we examined ass...
#1Erica B. Baller (UPenn: University of Pennsylvania)H-Index: 6
#2Alessandra M. Valcarcel (UPenn: University of Pennsylvania)H-Index: 4
Last. Carly O'Donnell (UPenn: University of Pennsylvania)
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To support brain development during youth, the brain must balance energy delivery and consumption. Previous studies in adults have demonstrated high coupling between cerebral blood flow and brain function as measured using functional neuroimaging, but how this relationship evolves over adolescence is unknown. To address this gap, we studied a sample of 831 children and adolescents (478 females, ages 8-22) from the Philadelphia Neurodevelopmental Cohort who were scanned at 3T with both arterial s...
#1Sara C. Taylor (UPenn: University of Pennsylvania)H-Index: 2
#2Samantha Steeman (UPenn: University of Pennsylvania)H-Index: 1
Last. Mahip Grewal (UPenn: University of Pennsylvania)H-Index: 1
view all 19 authors...
Autism spectrum disorder (ASD) comprises a multi-dimensional set of quantitative behavioral traits expressed along a continuum in autistic and neurotypical individuals. ASD diagnosis-a dichotomous trait-is known to be highly heritable and has been used as the phenotype for most ASD genetic studies. But less is known about the heritability of autism spectrum quantitative traits, especially in adults, an important prerequisite for gene discovery. We sought to measure the heritability of many autis...
#1Mathias Basner (UPenn: University of Pennsylvania)H-Index: 37
#2Tyler M. Moore (UPenn: University of Pennsylvania)H-Index: 37
Last. David F. Dinges (UPenn: University of Pennsylvania)H-Index: 109
view all 5 authors...
#1Tracy L. Fabri (York University)H-Index: 1
#1Tracy L Fabri (Children's Hospital of Philadelphia)
Last. E. Ann Yeh (U of T: University of Toronto)H-Index: 23
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Abstract null null Objective null The limbic system is involved in memory and in processing of emotional stimuli. We measured volume of the hippocampus, amygdala, and thalamus, and assessed their relative contribution to episodic memory and emotion identification in POMS. null null null Method null Sixty-five POMS participants (Mage = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration= 3.8 ± 3.8 years) and 76 age- and sex-matched controls (Mage = 18.1 ± 4.6 years; 49 female (64.5%)) ...
#1Adam Pines (UPenn: University of Pennsylvania)H-Index: 6
#2Bart Larsen (UPenn: University of Pennsylvania)H-Index: 12
Last. Ruben C. Gur (UPenn: University of Pennsylvania)H-Index: 148
view all 23 authors...
The brain is organized into networks at multiple resolutions, or scales, yet studies of functional network development typically focus on a single scale. Here, we derived personalized functional networks across 29 scales in a large sample of youths (n=693, ages 8-23 years) to identify multi-scale patterns of network re-organization related to neurocognitive development. We found that developmental shifts in inter-network coupling systematically adhered to and strengthened a functional hierarchy ...
#1Allysa Warling (NIH: National Institutes of Health)H-Index: 1
#2Cassidy L. McDermott (NIH: National Institutes of Health)H-Index: 4
Last. Tyler M. Moore (Children's Hospital of Philadelphia)H-Index: 37
view all 14 authors...
Anatomical organization of the primate cortex varies as a function of total brain size, where possession of a larger brain is accompanied by disproportionate expansion of associative cortices alongside a relative contraction of sensorimotor systems. However, equivalent scaling maps are not yet available for regional white matter anatomy. Here, we use three large-scale neuroimaging datasets to examine how regional white matter volume (WMV) scales with interindividual variation in brain volume amo...