Suxia Han
Xi'an Jiaotong University
CancerInternal medicineDownregulation and upregulationDNA damageOncologyCellMolecular biologyApoptosisHepatocellular carcinomaMetastasisProstate cancerOncogeneCell cycleCancer researchCarcinogenesisCell growthMedicineBiomarker (medicine)Cell cultureBiologyCell biology
55Publications
18H-index
1,051Citations
Publications 55
Newest
#1Minghua Bai (Xi'an Jiaotong University)H-Index: 1
#2Chenchen He (Xi'an Jiaotong University)H-Index: 8
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 9 authors...
Previous studies have shown that both long intergenic non-coding RNA 00963 (Linc00963) and tripartite motif containing 24 (TRIM24) are activators of the PI3K/AKT pathway, and both are involved in the carcinogenesis and progression of prostate cancer. However, the regulatory mechanisms between Linc00963 and TRIM24 are still unclear. In this study, we aimed to elucidate the underlying relationship between Linc00963 and TRIM24 in castration-resistant prostate cancer (CRPC). We found that TRIM24, an...
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#1Hao Wang (Xi'an Jiaotong University)H-Index: 5
#2Nan Wang (Zhengzhou University)H-Index: 2
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 8 authors...
Gastric cancer is the third leading cause of cancer-related death worldwide, with relapse and metastasis being major contributors to the mortality. Circular RNAs (circRNAs) have been at the center of several researches and some circRNAs have been indicated to be involved in gastric cancer as sponges. Nevertheless, the mechanism underlying the function of circRNA remains largely unclear. Therefore, this study was conducted with the main objective of screening the associated circRNA in gastric can...
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#1Liuyun Gong (Xi'an Jiaotong University)H-Index: 3
#2Zhenzhen Luo (Xi'an Jiaotong University)H-Index: 2
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 9 authors...
Abstract Background Breast cancer, cervical cancer, and ovarian cancer are three of the most commonly diagnosed malignancies in women, and more cancer prevention research is urgently needed. Methods Summary data of a large genome-wide association study of female cancers were derived from the UK biobank. We performed a transcriptome-wide association study and a gene set enrichment analysis to identify correlations between chemical exposure and aberrant expression, repression, or mutation of genes...
1 CitationsSource
#1Xinyue Tan (Xi'an Jiaotong University)H-Index: 4
#2Hanmin Tang (Xi'an Jiaotong University)H-Index: 2
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 9 authors...
Colorectal cancer (CRC) is the third most common cancer and has the second highest mortality rate in global cancer. Exploring the associations between chemicals and CRC has great significance in prophylaxis and therapy of tumor diseases. This study aims to explore the relationships between CRC and environmental chemicals on genetic basis by bioinformatics analysis. The genome-wide association study (GWAS) datasets for CRC were obtained from the UK Biobank. The GWAS data for colon cancer (categor...
1 CitationsSource
#1Minghua Bai (Xi'an Jiaotong University)H-Index: 1
#2Yutiantian Lei (Xi'an Jiaotong University)H-Index: 4
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 8 authors...
Previously, we found that the expression of long non-coding RNA (LncRNA) small nucleolar RNA host gene 17 (SNHG17) was up-regulated in castration-resistant prostate cancer (CRPC) cells compared to that in hormone sensitive prostate cancer (HSPC) cells. Moreover, we also found that CD51 was up-regulated in prostate cancer cells, and promoted the carcinogenesis and progression of prostate cancer. However, the regulatory mechanism of SNHG17 and CD51 in the development of CRPC remains unclear. In th...
4 CitationsSource
#1Liuyun Gong (Xi'an Jiaotong University)H-Index: 3
#2Hanmin Tang (Xi'an Jiaotong University)H-Index: 2
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 11 authors...
BACKGROUND Prevention of metabolic complications of long-term adjuvant endocrine therapy in breast cancers remained a challenge. We aimed to investigate the molecular mechanism in the development of tamoxifen (TAM)-induced fatty liver in both estrogen receptor (ER)-positive and ER-negative breast cancer. METHODS AND RESULTS First, the direct protein targets (DPTs) of TAM were identified using DrugBank5.1.7. We found that mitogen-activated protein kinase 8 (MAPK8) was one DPT of TAM. We identifie...
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#1Minghua Bai (Xi'an Jiaotong University)H-Index: 1
#2Yiping Dong (Xi'an Jiaotong University)H-Index: 6
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 6 authors...
Esophageal cancer has recent shown a higher incidence but lower 5-year survival rate after normal clinical treatment in China. The aim of this study was to observe whether the inhibition of miR-196a affects esophageal cancer cell growth by modulating the nuclear factor-kappaB target gene and to detect the possible cooperative therapeutic effects on esophageal cancer by knocking down miR-196a expression combined with the specific inhibitor of nuclear factor-kappaB target genes. Thus, anti-miR-196...
1 CitationsSource
#1Yuan-yuan Zhang (Xi'an Jiaotong University)H-Index: 5
#2Xia Ying (ZJU: Zhejiang University)H-Index: 2
Last. Suxia Han (Xi'an Jiaotong University)H-Index: 18
view all 7 authors...
Background. Hepatocellular carcinoma (HCC) is a malignant tumor associated with a poor prognosis. Serum biomarkers of HCC have the potential to improve the diagnosis, provide a means to monitor the tumors, and predict their malignancy. Proteins that are expressed differentially between HCC patients and normal controls have the potential to be biomarkers. Method. Serum samples from 10 confirmed HCC patients and 10 controls were collected. The differentially expressed proteins in the serum were id...
2 CitationsSource
#1Changlin Li (KU: University of Kansas)H-Index: 7
#2Chenchen He (KU: University of Kansas)H-Index: 2
Last. Benyi Li (KU: University of Kansas)H-Index: 10
view all 13 authors...
BACKGROUND: Alternol is a natural compound isolated from fermentation products of a mutant fungus. Our previous studies demonstrated that Alternol specifically kills cancer cells but spares benign cells. METHODS: To investigate the mechanism underlying alternol-induced cancer cell-specific killing effect, we took a comprehensive strategy to identify Alternol's protein targets in prostate cancer cells, including PC-3, C4-2, and 22RV1, plus benign BPH1 cell lines. Major experimental techniques inc...
11 CitationsSource
#1Xinyuan Yang (Xi'an Jiaotong University)H-Index: 1
#2He Shen (Roswell Park Cancer Institute)H-Index: 29
Last. Jianmin Zhang (Roswell Park Cancer Institute)H-Index: 11
view all 11 authors...
Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP). Nevertheless, how YAP is controlled by pathway crosstalks in tumourigenesis remains poorly understood. Here, we performed a targeted kinase inhibitor screen in human cancer cells to identify novel Hippo pathway regulators. Notably, we identified the nerve growth factor (NGF) receptor tyrosine kinase (NTRK1), a molecule ...
7 CitationsSource