Alexander C. Egbe
Mayo Clinic
Internal medicineSurgeryCardiologyRetrospective cohort studyHemodynamicsHazard ratioHeart failureTetralogy of FallotVentricleAtrial fibrillationAortaHeart diseasePulmonary arteryPopulationIn patientIncidence (epidemiology)DiastoleMedicineCohortEjection fractionBlood pressure
187Publications
20H-index
1,417Citations
Publications 187
Newest
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Nathaniel W. Taggart (Mayo Clinic)H-Index: 14
Last. Barry A. Borlaug (Mayo Clinic)H-Index: 76
view all 10 authors...
ABSTRACT Patients with tetralogy of Fallot (TOF) have abnormal right ventricular (RV) afterload because of residual or recurrent outflow tract obstruction, often with abnormal pulmonary artery (PA) vascular function. The purpose of this study was to determine if RV afterload was independently associated with death and/or heart transplant in patients with TOF. This is a retrospective study of TOF patients that underwent cardiac catheterization for clinical indications at Mayo clinic between 1990 ...
1 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Rosalyn Adigun (Mayo Clinic)H-Index: 4
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 9 authors...
Abstract Background Although there are robust data about the pathophysiology and prognostic implications of left ventricular (LV) systolic dysfunction in patients with acquired heart disease, similar prognostic data about LV systolic dysfunction are sparse in the tetralogy of Fallot (TOF) population. The purpose of this study was to perform a meta-analysis of all studies that assessed the relationship between LV ejection fraction (LVEF) and cardiovascular adverse events (CAE) defined as death, a...
5 CitationsSource
#1Yogesh N.V. Reddy (Mayo Clinic)H-Index: 26
#2Masaru Obokata (Mayo Clinic)H-Index: 22
Last. Barry A. Borlaug (Mayo Clinic)H-Index: 76
view all 9 authors...
AIMS : Increases in extravascular lung water (EVLW) during exercise contribute to symptoms, morbidity, and mortality in patients with heart failure and preserved ejection fraction (HFpEF), but the mechanisms leading to pulmonary congestion during exercise are not well-understood. METHODS AND RESULTS : Compensated, ambulatory patients with HFpEF (n = 61) underwent invasive haemodynamic exercise testing using high-fidelity micromanometers with simultaneous lung ultrasound, echocardiography, and ex...
62 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Crystal R. Bonnichsen (Mayo Clinic)H-Index: 14
Last. Barry A. Borlaug (Mayo Clinic)H-Index: 76
view all 5 authors...
Background Right atrial pressure (RAP), a composite metric of right ventricular diastolic function, volume status, and right heart compliance, is a predictor of mortality in patients with heart fai...
5 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Heidi M. Connolly (Mayo Clinic)H-Index: 75
Last. Hartzell V. Schaff (Mayo Clinic)H-Index: 131
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Background There are limited data on the incidence of prosthetic valve dysfunction (PVD) after pulmonary valve replacement (PVR). The purpose of this study was to determine the longevity of bioprosthetic valves in the pulmonary position and the factors associated with bioprosthetic valve longevity in adults with congenital heart disease. Methods This retrospective review of adults with bioprosthetic PVR was conducted at the Mayo Clinic in Rochester, Minnesota from 1990 to 2017. The study end poi...
6 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Thomas G. Allison (Mayo Clinic)H-Index: 40
Last. Naser M. Ammash (Mayo Clinic)H-Index: 35
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Exercise-induced hypertension is a predictor of cardiovascular events in patients with coarctation of aorta (COA). However, it is unclear whether mild COA diagnosis is an independent risk factor of...
5 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Maria Najam (Mayo Clinic)H-Index: 4
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 10 authors...
Right ventricular (RV) volume overload due to chronic pulmonary regurgitation is the common mechanism for hemodynamic deterioration after tetralogy of Fallot (TOF) repair. As a result, RV volumetric indices are used for clinical risk stratification in this population. Since RV afterload is a determinant of RV hemodynamic performance, we hypothesized that afterload-adjusted RV volumetric indices will have a better correlation with disease severity compared with RV volumetric indices alone in pati...
2 CitationsSource
#1M A Tamargo Delpon (Hospital General Universitario Gregorio Marañón)H-Index: 2
#2O Masaru (Mayo Clinic)
Last. Barry A. Borlaug (Mayo Clinic)H-Index: 76
view all 6 authors...
Source
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2William R. Miranda (Mayo Clinic)H-Index: 14
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 8 authors...
Abstract Background There are limited data about the outcomes mechanical prostheses in adults with tetralogy of Fallot (TOF). The purpose of the study was to describe the incidence of mechanical valve related adverse events (MVRAE), reoperation and all-cause mortality in TOF patients with mechanical valve prostheses. Methods We reviewed the MACHD (Mayo Adult Congenital Heart Disease) database and identified all adult TOF patients with mechanical valve prostheses, 1990–2017. MVRAE was defined as ...
1 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Saraschandra Vallabhajosyula (Mayo Clinic)H-Index: 8
Last. Abhishek Deshmukh (Mayo Clinic)H-Index: 35
view all 9 authors...
Abstract Background Although outcomes of arrhythmia diagnosis have been described in ambulatory tetralogy of Fallot (TOF) patients, these have not been studied in hospitalized patients. The purpose of this study was to determine the prevalence and in-hospital mortality due to arrhythmias in TOF patients based on a review of the National Inpatient Sample database. Methods Admissions in adult TOF patients (2000–2014) were categorized as arrhythmia-related admission (ARA) or non-arrhythmia-related ...
8 CitationsSource