Michael S. Hu
Stanford University
Regenerative medicineSurgeryPathologyStromal cellRegeneration (biology)Adipose tissueMesenchymal stem cellProgenitor cellIn vivoNeovascularizationWound healingFibroblastAngiogenesisFibrosisStem cellTissue engineeringCancer researchBioinformaticsMedicineBiologyCell biology
166Publications
24H-index
2,277Citations
Publications 141
Newest
#1Zeshaan N. Maan (Stanford University)H-Index: 25
#2Michael S. Hu (Stanford University)H-Index: 24
Last. Geoffrey C. Gurtner (Stanford University)H-Index: 83
view all 18 authors...
CXC chemokine ligand 12 (CXCL12; stromal cell-derived factor 1 [SDF-1]), primarily known for its role in embryogenesis and hematopoiesis, has also been implicated in tumor biology and neovascularization. However, its specific role and mechanism of action remain poorly understood. We previously demonstrated that CXCL12 expression is Hypoxia-Inducible Factor (HIF)-1 responsive. Here we use a conditional CXCL12 knockout mouse to show that endothelial-specific deletion of CXCL12 (eKO) does not affec...
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#1Michael S. Hu (Stanford University)H-Index: 24
#1Michael S. Hu (Stanford University)H-Index: 6
Last. Michael T. LongakerH-Index: 137
view all 19 authors...
Objective:The aim of this study was to determine the interaction of full thickness excisional wounds and tumors in vivo.Summary of Background Data:Tumors have been described as wounds that do not heal due to similarities in stromal composition. On the basis of observations of slowed tumor growth aft
1 CitationsSource
#1Tripp Leavitt (Stanford University)H-Index: 14
#2Michael S. Hu (Stanford University)H-Index: 24
Last. Michael T. Longaker (Stanford University)H-Index: 137
view all 29 authors...
Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsible for acute and chronic fibroses in the ventral dermis. Single-cell transcriptomics further corroborated the inherent fibrotic characteristics of Prrx1 fibroblasts during wound repair. In summary, we ...
8 CitationsSource
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#1Deshka S. Foster (Stanford University)H-Index: 10
#2Clement D. Marshall (Stanford University)H-Index: 10
Last. Michael T. Longaker (Stanford University)H-Index: 137
view all 25 authors...
Adhesions are fibrotic scars that form between abdominal organs following surgery or infection, and may cause bowel obstruction, chronic pain, or infertility. Our understanding of adhesion biology is limited, which explains the paucity of anti-adhesion treatments. Here we present a systematic analysis of mouse and human adhesion tissues. First, we show that adhesions derive primarily from the visceral peritoneum, consistent with our clinical experience that adhesions form primarily following lap...
10 CitationsSource
#1Zeshaan N. Maan (Stanford University)H-Index: 25
#2Michael S. Hu (Stanford University)H-Index: 24
Last. Geoffrey C. Gurtner (Stanford University)H-Index: 83
view all 15 authors...
CXC chemokine ligand 12 (CXCL12; stromal cell-derived factor 1 [SDF-1]), primarily known for its role in embryogenesis and hematopoiesis, has also been implicated in tumor biology and neovascularization. However, its specific role and mechanism of action remain poorly understood. We previously demonstrated that CXCL12 expression is Hypoxia-Inducible Factor (HIF)-1 responsive. Here we use a conditional CXCL12 knockout mouse to show that endothelial-specific deletion of CXCL12 (eKO) does not affec...
1 CitationsSource
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#1Mimi R. Borrelli (Stanford University)H-Index: 13
#2Michael S. HuH-Index: 24
Last. Hermann P. LorenzH-Index: 10
view all 4 authors...
: The craniofacial region is anatomically complex and is of critical functional and cosmetic importance, making reconstruction challenging. The limitations of current surgical options highlight the importance of developing new strategies to restore the form, function, and esthetics of missing or damaged soft tissue and skeletal tissue in the face and cranium. Regenerative medicine (RM) is an expanding field which combines the principles of tissue engineering (TE) and self-healing in the regenera...
11 CitationsSource