Mitsunobu R. Kano
Okayama University
MicelleCancerBiophysicsInternal medicineEndocrinologyPathologyDemographyMolecular biologyStromal cellNanotechnologyNanocarriersChemistryMaterials scienceIn vivoDrug deliveryPancreatic cancerAngiogenesisCancer researchMedicineBiologyCancer cell
104Publications
35H-index
5,332Citations
Publications 92
Newest
#1Ko Harada (Okayama University)H-Index: 3
#2Hideharu Hagiya (Okayama University)H-Index: 13
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 6 authors...
BACKGROUND The incidence of nontuberculous mycobacterial (NTM) infections has been increasing worldwide, becoming a significant healthcare burden especially among elderly people. This study aimed to evaluate the trends in NTM-associated mortality in Japan. METHODS This study used vital statistics data and data on all NTM-associated deaths (N=18,814) among individuals aged ≥40 years in Japan from 1997 to 2016. We calculated the crude and age-adjusted mortality rates by age and sex and used joinpo...
1 CitationsSource
#1Hideharu Hagiya (Okayama University)H-Index: 13
#2Toshihiro Koyama (Okayama University)H-Index: 13
Last. Mitsunobu R. Kano (Okayama University)H-Index: 35
view all 13 authors...
BACKGROUND AND AIM The current prevalence of hepatitis C virus infection and hepatitis C virus-associated mortality in Japan falls short of the World Health Organization goal of viral hepatitis elimination by 2030. We aimed to evaluate the trends in hepatitis C virus-associated mortality in Japan. METHODS This nationwide observational study used the Japanese Vital Statistics from 1998 to 2017 and included all Japanese hepatitis C virus-associated deaths (84,936) of adults aged ≥40 years. We calc...
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#1Tomoko Funahashi (Okayama University)H-Index: 1
#2Toshihiro Koyama (Okayama University)H-Index: 13
Last. Mitsunobu R. Kano (Okayama University)H-Index: 35
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Adverse drug events (ADEs) are a major cause of mortality. We examined long-term trends for ADE-related deaths in Japan. This observational study was conducted using the Japanese Vital Statistics from 1999 to 2016. Data for all ADE-related deaths were extracted using International Classification of Diseases, Tenth Revision codes. We analysed ADE-related deaths by age and sex and calculated crude and age-standardised mortality rates (ASMR) per 100,000 people. We used Joinpoint regression analysis...
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#1Hiroki TakashimaH-Index: 6
#2Yoshikatsu KogaH-Index: 21
Last. Mitsunobu R. Kano (Okayama University)H-Index: 35
view all 9 authors...
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#1Toshihiro Koyama (Okayama University)H-Index: 13
#2Hideharu Hagiya (Osaka University)H-Index: 13
Last. Mitsunobu R. KanoH-Index: 35
view all 15 authors...
Abstract Objectives Appropriate antibiotic prescriptions for outpatients with acute respiratory tract infections (ARTIs) are urgently needed in Japan. However, the empirical proof of this need is under-documented. Therefore, we aimed to determine antibiotic prescription rates, and the proportions of antibiotic classes prescribed for Japanese patients with ARTIs. Methods We analysed health insurance claims data over 2013–2015 among Japanese patients aged Results Among 8.65 million visits due to A...
2 CitationsSource
#1Toshihiro Koyama (Okayama University)H-Index: 13
#2Hideharu Hagiya (Okayama University)H-Index: 13
Last. Mitsunobu R. Kano (UTokyo: University of Tokyo)H-Index: 35
view all 13 authors...
Background: Globally, the number of deaths is estimated to increase to 74 million per year by 2030. Place of death (PoD) is increasingly being recognized as an important aspect of end-of-life care....
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#1Chiharu Morii (Okayama University)H-Index: 2
#2Hiroyoshi Y. Tanaka (Okayama University)H-Index: 7
Last. Aiko OgawaH-Index: 21
view all 8 authors...
In pulmonary arterial hypertension (PAH), excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) causes vascular medial thickening. Medial thickening is a histopathological hallmark of pulmonary vascular remodeling, the central disease process driving PAH progression. Pulmonary vascular remodeling causes stenosis and/or obstruction of small pulmonary arteries. This leads to increased pulmonary vascular resistance, elevated pulmonary arterial pressure, and ultimately right heart...
4 CitationsSource
#1Hiroyoshi Y. Tanaka (Okayama University)H-Index: 7
#2Tsuyoshi Kurihara (Okayama University)H-Index: 1
Last. Mitsunobu R. Kano (Okayama University)H-Index: 35
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Abstract Pancreatic ductal adenocarcinoma (PDAC) is an often lethal disease characterized by a dense, fibrotic stroma. However, the lack of relevant preclinical models that recapitulate the characteristic histopathology of human PDAC in vitro impedes the development of novel therapies. The amount of stromal elements differ largely within and between patients, but in vitro models of human PDAC often do not account for this heterogeneity. Indeed, analyses of human PDAC histopathology revealed that...
6 CitationsSource
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