Yongdoo Park
Korea University
Self-healing hydrogelsBiophysicsBiomedical engineeringCell migrationRegeneration (biology)ChemistryPolymer chemistryExtracellular matrixMaterials scienceMesenchymal stem cellHyaluronic acidEthylene oxideAngiogenesisBone regenerationChemical engineeringTissue engineeringMedicineAdhesionMicrofluidicsCell biology
95Publications
29H-index
3,432Citations
Publications 95
Newest
Collective cell migration of epithelial tumor cells is one of the important factors for elucidating cancer metastasis and developing novel drugs for cancer treatment. Especially, new roles of E-cadherin in cancer migration and metastasis, beyond the epithelial–mesenchymal transition, have recently been unveiled. Here, we quantitatively examined cell motility using micropatterned free edge migration model with E-cadherin re-expressing EC96 cells derived from adenocarcinoma gastric (AGS) cell line...
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#2Yongjun JangH-Index: 2
Last. Yongdoo ParkH-Index: 29
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Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of cardiac development, homeostasis, and regeneration. Since the heart is composed of various types of cells and extracellular matrix with a specific microenvironment, the fabrication of cardiac tissue in vitro requires integrating technologies of cardiac cells, biomaterials, fabrication, and computational modeling to model the complexity of heart tissue. Here, we review the recent progress of engineering te...
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#1Mirim KimH-Index: 1
#2Hwanseok JangH-Index: 6
Last. Yongdoo ParkH-Index: 29
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The movement of collective cells is affected through changes in physical interactions of cells in response to external mechanical stimuli, including fluid flow. Most tissues are affected by fluid flow at the interstitial level, but few studies have investigated the physical effects in collective cells affected by a low flow rate. In this study, collective cell migration of Madin–Darby canine kidney (MDCK) epithelial cells was investigated under static or interstitial flow (0, 0.1, and 1 μL/min) ...
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#1Yongjun JangH-Index: 2
#2Yongdoo ParkH-Index: 29
Last. Jongseong KimH-Index: 16
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The extracellular matrix (ECM) is needed to maintain the structural integrity of tissues and to mediate cellular dynamics. Its main components are fibrous proteins and glycosaminoglycans, which provide a suitable environment for biological functions. Thus, biomaterials with ECM-like properties have been extensively developed by modulating their key components and properties. In the field of cardiac tissue engineering, the use of biomaterials offers several advantages in that biophysical and bioc...
2 CitationsSource
#1Myeongjin SongH-Index: 6
#2Jongseong KimH-Index: 16
Last. Seung-Jong Kim (KU: Korea University)H-Index: 5
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Regulation of cell signaling through physical stimulation is an emerging topic in biomedicine. Background: While recent advances in biophysical technologies show capabilities for spatiotemporal stimulation, interfacing those tools with biological systems for intact signal transfer and noncontact stimulation remains challenging. Here, we describe the use of a magnetic torque stimulation (MTS) system combined with engineered magnetic particles to apply forces on the surface of individual cells. MT...
1 CitationsSource
#1Yong Guk Kang (KU: Korea University)H-Index: 4
#2Hwanseok Jang (KU: Korea University)H-Index: 6
Last. Beop-Min Kim (KU: Korea University)H-Index: 24
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The extracellular matrix (ECM) plays a key role during cell migration, proliferation, and differentiation by providing adhesion sites and serving as a physical scaffold. Elucidating the interaction between the cell and ECM can reveal the underlying mechanisms of cellular behavior that are currently unclear. Analysis of the deformation of the ECM due to cell–matrix interactions requires microscopic, three-dimensional (3-D) imaging methods, such as confocal microscopy and second-harmonic generatio...
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#1Yongjun Jang (KU: Korea University)H-Index: 2
#2Da Jung Jung (Asan Medical Center)H-Index: 3
Last. Yongdoo Park (KU: Korea University)H-Index: 29
view all 8 authors...
Correction for ‘Multidimensional assembly using layer-by-layer deposition for synchronized cardiac macro tissues’ by Yongjun Jang et al., RSC Adv., 2020, 10, 18806–18815, DOI: 10.1039/D0RA01577F.
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#1Yongjun Jang (KU: Korea University)H-Index: 2
#2Da Jung Jung (Asan Medical Center)H-Index: 1
Last. Yongdoo Park (KU: Korea University)H-Index: 29
view all 8 authors...
The fabrication of biomimetic structures for tissues and organs is emerging in the fields of biomedical engineering and precision medicine. While current progress in biomedical research provides a number of biofabrication methods, the construction of multi-dimensional cardiac tissue is highly challenging due to difficulties in the maturation and synchronization of cardiomyocytes (CMs) in conjunction with other types of cells, such as myofibroblasts and endothelial cells. Here, we show a simple f...
1 CitationsSource
#1Hae Min Yang (SNU: Seoul National University)H-Index: 1
#2Jie Ying Teoh (SNU: Seoul National University)H-Index: 1
Last. Dongwon Yoo (SNU: Seoul National University)H-Index: 19
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Precise identification of protein-protein interactions is required to improve our understanding of biochemical pathways for biology and medicine. In physiology, how proteins interact with other proteins or small molecules is crucial for maintaining biological functions. For instance, multivalent protein binding (MPB), in which a ligand concurrently interacts with two or more receptors, plays a key role in regulating complex but accurate biological functions, and its interference is related to ma...
7 CitationsSource
#1Yongjun Jang (KU: Korea University)H-Index: 2
#2Seung Cheol Choi (KU: Korea University)H-Index: 15
Last. Yongdoo Park (KU: Korea University)H-Index: 29
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Maturation and synchronisation of heart cells, including cardiomyocytes and fibroblasts, are essential to develop functional biomimetic cardiac tissues for regenerative medicine and drug discovery. Synchronisation of cells in the biomimetic cardiac tissue requires the structural integrity and functional maturation of cardiomyocytes with other cell types. However, it is challenging to synchronise the beating of macroscale cardiac tissues and induce maturation of cardiomyocytes derived from stem c...
6 CitationsSource