Lina María Ruiz
Autonomous University of Chile
GeneQuorum sensingElectron transferInternal medicineExtracellular polymeric substanceMitochondrial permeability transition poreComputational chemistryCellular differentiationCellmitochondrial fusionDNA vaccinationChemical bondChemistryApoptosisAromaticityCopper deficiencyMFN1FIS1AntioxidantErythropoiesisMitochondrionRespiratory chainMoleculeEffectorBacteriaBiochemistryBiofilmBiominingStereochemistryBiologyMicrobiologyCell biologyBioleachingRing current
41Publications
13H-index
603Citations
Publications 42
Newest
Source
Previous experimental results on the free radical-scavenging properties of boldine, one of the most potent natural antioxidants, suggested that the benzylic hydrogen, neighboring a nitrogen lone electron pair, might be the key to its protective and antioxidant effect, in contrast to the usually assumed labile phenolic hydrogen atoms. Our computations suggest that both boldine and glaucine can undergo two successive hydrogen transfers under attack by an oxidizing radical (from C-6a-H and C-7-H). ...
Source
#1Alvaro M. Gonzalez-Ibanez (Andrés Bello National University)H-Index: 3
#2Lina María RuizH-Index: 13
Last. Alvaro A. Elorza (Andrés Bello National University)H-Index: 20
view all 8 authors...
Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and mature into erythrocytes. During erythropoiesis, mitochondria are reprogrammed to drive the differentiation process before finally being eliminated by mitophagy. In erythropoiesis, mitochondrial dynamics (MtDy) are expected to be a key regulatory poin...
4 CitationsSource
#1Alvaro M. Gonzalez-Ibanez (Andrés Bello National University)H-Index: 3
#2Lina María RuizH-Index: 13
Last. Alvaro A. Elorza (Andrés Bello National University)H-Index: 20
view all 8 authors...
Erythropoiesis is the most powerful cellular differentiation and proliferation system, with a production of 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, which proliferate and mature into erythrocytes. During erythropoiesis, mitochondria are reprogrammed to drive the differentiation process before finally being eliminated by mitophagy. In erythropoiesis, mitochondrial dynamics (MtDy) is expected to be a regulatory key point th...
1 CitationsSource
#1Celia SalazarH-Index: 4
#2Osvaldo Yañez (Andrés Bello National University)H-Index: 8
Last. Lina María RuizH-Index: 13
view all 7 authors...
The expression of HIGD2A is dependent on oxygen levels, glucose concentration, and cell cycle progression. This gene encodes for protein HIG2A, found in mitochondria and the nucleus, promoting cell survival in hypoxic conditions. The genomic location of HIGD2A is in chromosome 5q35.2, where several chromosomal abnormalities are related to numerous cancers. The analysis of high definition expression profiles of HIGD2A suggests a role for HIG2A in cancer biology. Accordingly, the research objectiv...
3 CitationsSource
#1Alejandro Vásquez-Espinal (Andrés Bello National University)H-Index: 10
#2Osvaldo Yañez (Andrés Bello National University)H-Index: 8
Last. William Tiznado (Andrés Bello National University)H-Index: 23
view all 8 authors...
It was recently shown that, when tested in cellular systems, quercetin oxidized products (Qox) have significantly better antioxidant activity than quercetin (Q) itself. The main Qox identified in the experiments are either 2,5,7,3′,4′-pentahydroxy-3,4-flavandione (Fl) or its tautomer, 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (Bf). We have now performed a theoretical evaluation of different physicochemical properties using density functional theory (DFT) calculations on Q and...
16 CitationsSource
#1Celia SalazarH-Index: 4
#2Alvaro A. Elorza (Andrés Bello National University)H-Index: 20
Last. Lina María RuizH-Index: 13
view all 6 authors...
: HIG2A promotes cell survival under hypoxia and mediates the assembly of complex III and complex IV into respiratory chain supercomplexes. In the present study, we show that human HIGD2A and mouse Higd2a gene expressions are regulated by hypoxia, glucose, and the cell cycle-related transcription factor E2F1. The latter was found to bind the promoter region of HIGD2A. Differential expression of the HIGD2A gene was found in C57BL/6 mice in relation to tissue and age. Besides, the silencing of HIG...
10 CitationsSource
#1Manuel CarrascoH-Index: 1
#2Celia SalazarH-Index: 4
Last. Lina María RuizH-Index: 13
view all 4 authors...
Autistic Spectrum Disorder (ASD) is characterized by the impairment of socio-communicative skills and the presence of restricted and stereotyped behavior patterns. Recent researches have revealed the influence of mitochondrial physiology on the development of ASD. Several research groups have identified defects in respiratory complexes, coenzyme-Q10 deficiency, increased oxidative damage, decreased of superoxide dismutase (SOD2). A study on the influence of mitochondrial physiology on the develo...
8 CitationsSource
#1Osvaldo Yañez (Andrés Bello National University)H-Index: 8
#2Alejandro Vásquez-Espinal (Andrés Bello National University)H-Index: 10
Last. William Tiznado (Andrés Bello National University)H-Index: 23
view all 7 authors...
A simple and chemically intuitive approach is used to design ptC-containing E–C clusters (E = Si–Pb). This approach consists in replacing three or two consecutive protons from an aromatic hydrocarbon by one E24+ or one E2+ fragment, respectively. In the model, electrons from E are removed from the pz orbitals, emptying them. Si–Pb favors the formation of a 3c-2e (E–C–E) σ-bond, which involves the ptC. Additionally, the π-electronic cloud is delocalized through the E-pz orbitals allowing the E at...
13 CitationsSource
#1Ricardo Pino-RiosH-Index: 9
Last. William Tiznado (Andrés Bello National University)H-Index: 23
view all 4 authors...
: In all molecules, a current density is induced when the molecule is subjected to an external magnetic field. In turn, this current density creates a particular magnetic field. In this work, the bifurcation value of the induced magnetic field is analyzed in a representative set of aromatic, non-aromatic and antiaromatic monocycles, as well as a set of polycyclic hydrocarbons. The results show that the bifurcation value of the ring-shaped domain adequately classifies the studied molecules accord...
6 CitationsSource