Roberto Sánchez-Sánchez
National Autonomous University of Mexico
Self-healing hydrogelsBiomedical engineeringChemistryExtracellular matrixMaterials scienceMesenchymal stem cellGraftingBiocompatibilityStaphylococcus aureusPolyurethaneChitosanWound healingFibroblastSilver nanoparticleChemical engineeringPolymerizationAntimicrobialTissue engineeringViability assayBiofilmBiologyMicrobiologyCell biology
32Publications
8H-index
300Citations
Publications 28
Newest
#2Ilian Haide Serrano-Aguilar (UNAM: National Autonomous University of Mexico)
Last. Cristina VelasquilloH-Index: 10
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Abstract A novel brush-like poly(2-aminoethyl methacrylate) (PAEMA) was grafted onto chitosan (CS) through gamma radiation-induced polymerization. The copolymer (CS-g-PAEMA) was used to prepare a sodium acetate leached poly(urethane-urea) scaffold. The above derivatives were developed, synthesized, and characterized to meet the specific characteristics of biomaterials. The results revealed that this method is an easy and successful route for grafting PAEMA onto CS. The feasibility of preparing a...
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Last. José González-Valdez (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 14
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Abstract This work aims to study the bio-interfacial properties of poly(ester-urethane) composite scaffolds based on poly (3-hydroxybutyrate) [PHB] and modified by surface plasma-radiation-induced graft polymerization of N-isopropylacrylamide (NIPAAm). The delivering power of the Argon radio-frequency plasma was increased from 5−20 W. The yields over the polyurethane surface, grafting density, topographical dimensions, architecture, surface energy, and wettability were surveyed in the establishe...
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#1Claudia Adriana Colín-Castro (IPN: Instituto Politécnico Nacional)H-Index: 5
Last. Jonathan J. Magaña (Tec: Monterrey Institute of Technology and Higher Education)H-Index: 15
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Sepsis is a life-threatening organ dysfunction condition caused by a dysregulated response to an infection that is common among patients with moderate to severe burn injury. Previously, genomic variants in Toll-like receptor 4 (TLR4), a key innate immunity receptor, have been associated with sepsis and infection susceptibility. In this study, the association of six TLR4 SNPs with sepsis after burn injury was tested in the Mexican mestizo population. We found that the rs2737190 polymorphism is as...
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Cytokines like IL-6, TNF-α, and IL-1β are important mediators of inflammation in many inflammatory diseases, as well as in cellular processes like cell proliferation and cell adhesion. Finding new molecules that decrease cell proliferation, adhesion (inflammatory infiltrate), and pro-inflammatory cytokine release could help in the treatment of many inflammatory diseases. The naturally derived poly(gallic acid) (PGAL), produced enzymatically from gallic acid in aqueous medium, is a non-toxic, the...
3 CitationsSource
#1Fernanda Kamila Godoy-Alvarez (UNAM: National Autonomous University of Mexico)
Last. Gerardo Leyva-Gómez (UNAM: National Autonomous University of Mexico)H-Index: 12
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Hyaluronic acid (HA) is one of the most attractive natural polymers employed in biomaterials with biological applications. This polysaccharide is found in different tissues of the body because it is a natural component of the extracellular matrix; furthermore, it has crucial functions in cell growth, migration, and differentiation. Since its biological characteristics, HA has been utilized for the new biomaterial’s development for tissue engineering, such as hydrogels. These hydrophilic macromol...
1 CitationsSource
#1María L. Del Prado-Audelo (UNAM: National Autonomous University of Mexico)H-Index: 7
#2Francisco J. Gómez-Zaldivar (UNAM: National Autonomous University of Mexico)
Last. Gerardo Leyva-Gómez (UNAM: National Autonomous University of Mexico)H-Index: 12
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The purpose of our study was to obtain new wound dressings in the form of hydrogels that promote wound healing taking advantage of the broad activities of elastin (ELT) in physiological processes. The hydrogel of ELT and polyvinylpyrrolidone (PVP; ELT–PVP) was obtained by cross-linking induced by gamma irradiation at a dose of 25 kGy. The physicochemical changes attributed to cross-linking were analyzed through scanning electron microscopy (SEM), infrared spectroscopy analysis with Fourier trans...
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#1Montserrat Lopez-Carrizales (Universidad Autónoma de San Luis Potosí)H-Index: 2
#2E. Mendoza-Mendoza (Universidad Autónoma de San Luis Potosí)H-Index: 7
Last. Fidel Martinez-Gutierrez (Universidad Autónoma de San Luis Potosí)H-Index: 13
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Abstract The purpose of this study was to generate novel chitosan hydrogels (CHs) loaded with silver nanoparticles (AgNPs) and ampicillin (AMP) to prevent early formation of biofilms. AgNPs and CHs were characterized by UV-Vis, DLS, TEM, rheology, FT-IR, Raman, and SEM. The antibiofilm effect of the formulations was investigated against four multidrug-resistant and extensively drug-resistant pathogens using a colony biofilm, a high cell density and gradients model. Also, their hemostatic propert...
3 CitationsSource
#1Eric Ivan Ochoa-Segundo (UNAM: National Autonomous University of Mexico)H-Index: 1
Last. Rogelio Rodríguez-Talavera (UNAM: National Autonomous University of Mexico)H-Index: 2
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Abstract This study aimed at investigating the synthesis, characterization, and search for a biotechnological application proposal for poly [(R)-3-hydroxybutyric acid] (PHB) grafted with the n-hydroxyethyl acrylamide (HEAA) monomer. The novel copolymer was prepared by 60Co gamma radiation-induced-graft polymerization. The effect of different solvents in the graft polymerization; the degree of grafting, crystallinity, and hydrophilicity; the morphology and the thermal properties were evaluated. T...
2 CitationsSource
#2Alberto Ramírez-Mata (BUAP: Benemérita Universidad Autónoma de Puebla)H-Index: 5
Last. Cristina VelasquilloH-Index: 10
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Abstract A poly(ester-urethane) nanocomposite based on 1,6-hexamethylene diisocyanate-trimer, poly(3-hydroxybutyrate), and silica nanoparticles was prepared. The porosity model involved the sodium-acetate in situ particulate leaching technique. Also, the diversity of applications (multifunctionality) of these composite scaffolds is currently unknown. Herein, the scaffold surface topography, cell adhesion, viability, and the use of Azospirillum brasilense to produce biofilms were investigated. Th...
1 CitationsSource
#1Valentina Alejandra Segovia-Hernández (IPN: Instituto Politécnico Nacional)H-Index: 1
Last. Rosa María Ribas-Aparicio (IPN: Instituto Politécnico Nacional)H-Index: 10
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Abstract The synthesis of the poly(ester-urethanes) using poly(3-hydroxybutyrate) has gained increasing interest as scaffolds for use in tissue engineering despite their moderate hydrophobicity and biocompatibility. However, it is not yet known if the grafting of poly(N‐hydroxyethyl acrylamide) is suitable to improve the degree of hydrophilicity of the surface. This study aims to tailor the surface of these biopolymers by plasma-induced graft polymerization of N‐hydroxyethyl acrylamide. The synt...
3 CitationsSource