Marlene C. W. Stewart
University of Edinburgh
Genome-wide association studyInternal medicineSurgerySingle-nucleotide polymorphismOdds ratioPsychologyRandomized controlled trialCognitionPhysical therapyCohort studyImmunologyPlaceboVaricose veinsAspirinAsymptomaticAnkleCompression stockingsDementiaIndex (economics)C-reactive proteinPopulationVaricose UlcerCognitive declineClinical trialGeneticsCognitive testMedicineMeta-analysis
Publications 34
#1Alina Andras (Keele University)H-Index: 11
#2Adriano Sala Tenna (Newcastle upon Tyne Hospitals NHS Foundation Trust)H-Index: 1
Last. Marlene C. W. Stewart (Edin.: University of Edinburgh)H-Index: 20
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Patients who have had an episode of symptomatic venous thromboembolism are usually treated for at least five days with intravenous unfractionated heparin or subcutaneous low-molecular-weight heparin. Thereafter, they received a three month course of a vitamin K antagonist, with a dose adjusted to achieve an International Normalized Ratio between 2.0 and 3.0. Some patients have contraindications to vitamin K antagonists. In addition, treatment with vitamin K antagonists has the disadvantage of re...
12 CitationsSource
#1Lindsay Robertson (Freeman Hospital)H-Index: 22
#1Lindsay Robertson (Freeman Hospital)H-Index: 15
Last. Marlene C. W. Stewart (Edin.: University of Edinburgh)H-Index: 20
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This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To summarise the evidence from relevant Cochrane Reviews regarding effectiveness of angioplasty and stenting for peripheral arterial disease of the lower limbs.
3 CitationsSource
#1Francesca M Chappell (Edin.: University of Edinburgh)H-Index: 30
#2Alina Andras (Keele University)H-Index: 11
Last. Fay Crawford (Queen Margaret Hospital)H-Index: 20
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This is the protocol for a review and there is no abstract. The objectives are as follows: To estimate the sensitivity and specificity of the various types of D-dimer test in the diagnosis of deep vein thrombosis (DVT) of the lower limb in symptomatic outpatients with a clinical prediction rule score. Patients' clinical prediction rule scores will be used to assess D-dimer test accuracy in different risk groups. To investigate the following as potential sources of heterogeneity: age, sex, cancer...
1 CitationsSource
#1Christopher E Clark (University of Exeter)H-Index: 19
#2Rod S Taylor (University of Exeter)H-Index: 104
Last. John Campbell (University of Exeter)H-Index: 120
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Background Differences in blood pressure between arms are associated with increased cardiovascular mortality in cohorts with established vascular disease or substantially elevated cardiovascular risk. Aim To explore the association of inter-arm difference (IAD) with mortality in a community-dwelling cohort that is free of cardiovascular disease. Design and setting Cohort analysis of a randomised controlled trial in central Scotland, from April 1998 to October 2008. Method Volunteers from Lanarks...
26 CitationsSource
#1Rachel Forster (Edin.: University of Edinburgh)H-Index: 8
#2Marlene C. W. Stewart (Edin.: University of Edinburgh)H-Index: 20
Background The optimal duration of thromboprophylaxis after total hip or knee replacement, or hip fracture repair remains controversial. It is common practice to administer prophylaxis using low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) until discharge from hospital, usually seven to 14 days after surgery. International guidelines recommend extending thromboprophylaxis for up to 35 days following major orthopaedic surgery but the recommendation is weak due to moderate quali...
38 CitationsSource
#1Marlene C. W. Stewart (Edin.: University of Edinburgh)H-Index: 20
#2Joanne R Morling (University of Nottingham)H-Index: 16
Last. Heather MaxwellH-Index: 4
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Intermittent claudication (IC) is pain in the leg that occurs on exercise and is relieved by rest. It is caused by an inadequate blood supply to the legs due to blockage of arteries. Conservative drug treatment is commonly used in an attempt to improve walking distance in these patients. Padma 28 is a Tibetan herbal preparation used for treating intermittent claudication. This review on the effects of Padma 28 includes five trials with a total of 365 participants. The review showed that Padma 28...
3 CitationsSource
Last. Thomas H. MosleyH-Index: 95
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1 Citations
#1Carla A. Ibrahim-Verbaas (EUR: Erasmus University Rotterdam)H-Index: 18
#2Jan Bressler (University of Texas Health Science Center at Houston)H-Index: 30
Last. Thomas H. Mosley (University of Mississippi)H-Index: 95
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To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429–32 070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time...
84 CitationsSource
#1Daniel I. Swerdlow (UCL: University College London)H-Index: 21
#2David Preiss (Glas.: University of Glasgow)H-Index: 48
Last. Naveed Sattar (Glas.: University of Glasgow)H-Index: 172
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Summary Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-C oA reductase (HMGCR), the intended drug target. Methods We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 ( for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose...
399 CitationsSource
#1F. GeraldH-Index: 2
#2R. FowkesH-Index: 2
Last. Gordon D. MurrayH-Index: 112
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2 Citations