Christian Vergara
Polytechnic University of Milan
AlgorithmPhysicsMathematical optimizationInternal medicineMathematical analysisWork (thermodynamics)Biomedical engineeringBlood flowCardiologyVolumetric flow rateHemodynamicsBoundary value problemFluid–structure interactionApplied mathematicsMathematicsComputer scienceSimulationConvergence (routing)MedicineFluid dynamics
126Publications
24H-index
1,921Citations
Publications 124
Newest
#1Lorenzo Bennati (University of Verona)
#2Christian Vergara (Polytechnic University of Milan)H-Index: 24
Last. Renato CasanaH-Index: 13
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Atherosclerosis is a systemic disease that leads to accumulation of deposits, known as atherosclerotic plaques, within the walls of the carotids. In particular, three types of plaque can be distinguished: soft, fibrous and calcific. Most of the computational studies who investigated the interplay between the plaque and the blood flow on patient-specific geometries, used non standard medical images to directly delineate and segment the plaque and its components. However these techniques are not s...
5 CitationsSource
We consider a loosely coupled algorithm for fluid-structure interaction based on a Robin interface condition for the fluid problem (explicit Robin-Neumann scheme). We study the dependence of the stability of this method on the interface parameter in the Robin condition. In particular, for a model problem we find sufficient conditions for instability and stability of the method. In the latter case, we found a stability condition relating the time discretization parameter, the interface parameter,...
2 CitationsSource
#1Roberto PiersantiH-Index: 1
#2Francesco Regazzoni (Polytechnic University of Milan)H-Index: 28
Last. Alfio QuarteroniH-Index: 83
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Two crucial factors for accurate numerical simulations of cardiac electromechanics, which are also essential to reproduce the synchronous activity of the heart, are: i) accounting for the interaction between the heart and the circulatory system that determines pressures and volumes loads in the heart chambers; ii) reconstructing the muscular fiber architecture that drives the electrophysiology signal and the myocardium contraction. In this work, we present a 3D biventricular electromechanical mo...
#1Silvia Pozzi (Polytechnic University of Milan)H-Index: 1
#2Alberto Redaelli (Polytechnic University of Milan)H-Index: 49
Last. Paolo Zunino (Polytechnic University of Milan)H-Index: 28
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In this work we propose a mathematical and numerical model to describe the early stages of atherosclerotic plaque formation, which is based on the interaction of processes with different spatial and temporal scales. A fluid–structure interaction problem, used to describe the cardiovascular mechanics arising between blood and the artery wall, is coupled to a set of differential problems describing the evolution of solute concentrations. In order to manage the multiscale-in-space nature of the inv...
Source
We consider two loosely coupled schemes for the solution of the fluid–structure interaction problem in the presence of large added mass effect. In particular, we introduce the Robin–Robin and Robin–Neumann explicit schemes where suitable interface conditions of Robin type are used. For the estimate of interface Robin parameters which guarantee stability of the numerical solution, we propose a new strategy based on the optimization of the reduction factor of the corresponding strongly coupled (im...
1 CitationsSource
#1Marco Martinolli (Polytechnic University of Milan)
#2Jacopo BiasettiH-Index: 5
Last. Christian Vergara (Polytechnic University of Milan)H-Index: 24
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Numerical simulations of cardiac blood pump systems are integral to the optimization of device design, hydraulic performance and hemocompatibility. In wave membrane blood pumps, blood propulsion arises from the wave propagation along an oscillating immersed membrane, which generates small pockets of fluid that are pushed towards the outlet against an adverse pressure gradient. We studied the Fluid-Structure Interaction between the oscillating membrane and the blood flow via three-dimensional sim...
1 CitationsSource
#2Francesco Regazzoni (Polytechnic University of Milan)H-Index: 28
#3Christian Vergara (Polytechnic University of Milan)H-Index: 24
Last. Alfio QuarteroniH-Index: 83
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Emerging studies address how COVID-19 infection can impact the human cardiovascular system This relates particularly to the development of myocardial injury, acute coronary syndrome, myocarditis, arrhythmia, and heart failure Prospective treatment approach is advised for these patients To study the interplay between local changes (reduced contractility), global variables (peripheral resistances, heart rate) and the cardiac function, we considered a lumped parameters computational model of the ca...
1 CitationsSource
#1Silvia Pozzi (Polytechnic University of Milan)H-Index: 1
#2Maurizio Domanin (University of Milan)H-Index: 9
Last. Christian Vergara (Polytechnic University of Milan)H-Index: 24
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We propose a surrogate model for the fluid-structure interaction (FSI) problem for the study of blood dynamics in carotid arteries in presence of plaque. This is based on the integration of a numerical model with subject-specific data and clinical imaging. We propose to model the plaque as part of the tissues surrounding the vessel wall through the application of an elastic support boundary condition. In order to characterize the plaque and other surrounding tissues, such as the close-by jugular...
1 CitationsSource
#1Stefano ZoncaH-Index: 6
#2Paola F. AntoniettiH-Index: 23
Last. Christian VergaraH-Index: 24
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1 CitationsSource
#1Roberto Piersanti (Polytechnic University of Milan)H-Index: 1
#2Pasquale Claudio Africa (Polytechnic University of Milan)H-Index: 4
Last. Alfio Quarteroni (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 83
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Abstract Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used strategy to include cardiac fibers in computational models. A particular class of such methods is known as Laplace–Dirichlet-Rule-Based-Methods (LDRBMs) since they rely on the solution of Laplace problems. In this work we provide a unified framework, bas...
16 CitationsSource