Qixiao Zhai
Jiangnan University
Internal medicineChemistryImmunologyLactic acidOxidative stressBacteroidesLactobacillus plantarumLactobacillusProbioticBifidobacteriumToxicityFood scienceBacteriaGut floraBiochemistryMedicineBiologyImmune systemMicrobiologyPharmacology
120Publications
21H-index
1,530Citations
Publications 118
Newest
#1Leilei YuH-Index: 13
#2Yaqi YuH-Index: 1
Last. Wei ChenH-Index: 74
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#1Miaoyu Li (Jiangnan University)
#2Leilei Yu (Jiangnan University)H-Index: 13
Last. Fengwei TianH-Index: 27
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Abstract Edible mushrooms as valuable health foods have potential beneficial effects, and these beneficial activities are connected with the modulation of gut microbiota. In this review, we discuss the regulation of gut microbiota by edible mushroom. Ganoderma lucidum increases Bacteroides/Firmicutes ratio, and promote the growth of anti-inflammatory and short-chain fatty acid (SCFA) producing bacteria. Hericium erinaceus maintains intestinal barrier integrity, and increases the diversity and ri...
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#1Shenyan Ma (Jiangnan University)H-Index: 7
#2Jiang Cao (Jiangnan University)H-Index: 1
Last. Qixiao Zhai (Jiangnan University)H-Index: 21
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ABSTRACT Bacillus coagulans has been widely studied for its probiotic properties. Therefore, identifying a strain that can be used as an adjunct starter culture for yogurt production would have commercial value. In this study, 30 B. coagulans strains were isolated from vegetable samples from 11 provinces or autonomous regions in China, and their pan-genomic and phylogenetic characteristics were analyzed. Phylogenetic analysis categorized 30 strains into 4 different subphylotypes, including subty...
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#1Dezhi Lu (Jiangnan University)
#2Leilei Yu (Jiangnan University)H-Index: 13
Last. Wei ChenH-Index: 154
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Abstract Nonylphenol (NP) is widely used in daily production and life due to its good emulsification. In this review, we discuss toxicology studies that examined behavioral disorders caused by NP, the corresponding toxicological mechanisms in the central nervous system (CNS), and strategies for protection. Available in vitro and in vivo evidence suggests that exposure to NP during adulthood or early childhood is associated with cognitive dysfunction, including depression-like behaviors, anxiety-...
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#1Chen Wang (Jiangnan University)H-Index: 4
#2Sijia Li (Jiangnan University)H-Index: 1
Last. Qixiao Zhai (Jiangnan University)H-Index: 21
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A novel strictly anaerobic, Gram-negative bacterium, designated as strain FXJYN30E22T, was isolated from the feces of a healthy woman in Yining county, Xinjiang province, China. This strain was non-spore-forming, bile-resistant, non-motile and rod-shaped. It was found to belong to a single separate group in the Phocaeicola genus based on its 16 S ribosomal RNA (rRNA) gene sequence. Alignments of 16 S rRNA gene sequences showed only a low sequence identity (≤ 95.5 %) between strain FXJYN30E22T an...
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#7Wei Chen (Jiangnan University)H-Index: 74
Psoriasis is an immune-mediated systemic disease that may be treated with probiotics. In this study, probiotic strains that could or could not decrease interleukin (IL)-17 levels were applied to imiquimod (IMQ)-induced psoriasis-like mice via oral administration. Bifidobacterium adolescentis CCFM667, B. breve CCFM1078, Lacticaseibacillus paracasei CCFM1074, and Limosilactobacillus reuteri CCFM1132 ameliorated psoriasis-like pathological characteristics and suppressed the release of IL-23/T helpe...
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#1Peng Jiang (Jiangnan University)
#2Xinjie YuH-Index: 1
Last. Qixiao Zhai (Jiangnan University)H-Index: 21
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Abstract The link between the gut microbiome and bone health has begun to attract widespread interest in recent years. The gut microbiome are vital in many diseases involving bone loss. Probiotics, prebiotics, and dietary supplements have been suggested to protect bone health by altering the composition of the gut microbiota. Notably, studying the relationship between the gut microbiome and bone health can provide a basis for the prevention and treatment of bone diseases. This review focuses on ...
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Although the beneficial effects of probiotics are likely to be associated with their ability to colonize the gut, little is known about the characteristics of good colonizers. In a systematic analysis of the comparative genomics, we tried to elucidate the genomic contents that account for the distinct host adaptability patterns of Lactobacillus and Bifidobacterium species. The Bifidobacterium species, with species-level phylogenetic structures affected by recombination among strains, broad mucin...
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#1Yan Zhao (Jiangnan University)H-Index: 1
#2Leilei Yu (Jiangnan University)H-Index: 13
Last. Qixiao Zhai (Jiangnan University)H-Index: 21
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Research studies have shown that Lactobacillus fermentum generally exists in the human gut and has potential health benefits on host health due to its antimicrobial and antioxidant properties. However, the lack of an effective culture medium for the isolation of L. fermentum has presented a significant obstacle on the path to screen L. fermentum strains from the human intestinal tract with a large diversity of commensal microbes. In this study, a total of 51 Lactobacillus species are detected in...
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#1Chengcheng Zhang (Jiangnan University)H-Index: 6
#2Yan Zhao (Jiangnan University)H-Index: 1
Last. Qixiao Zhai (Jiangnan University)H-Index: 21
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Bifidobacterium longum (B. longum) species are widely used to prevent and treat ulcerative colitis (UC). In this study, phylogenetic and pan-genomic characterization of 122 B. longum strains was performed on the basis of 936 core genes; among these, four strains from different branches of the phylogenetic tree were selected for an evaluation of anti-inflammatory and immune modulatory activities in a DSS-induced colitis mouse model. Among the tested B. longum strains (B. longum FBJ20M1, B. longum...
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