Joji Ishida
Okayama University
Internal medicineNeurosurgerySurgeryPathologyVascular endothelial growth factor ACellIntegrinGlioblastomaVascular endothelial growth factorBevacizumabGliomaCilengitideAngiogenesisCancer researchText miningMedicineCell cultureBiologyGastroenterologyPharmacology
39Publications
10H-index
243Citations
Publications 40
Newest
#1Hirokazu Takami (UTokyo: University of Tokyo)H-Index: 3
#2Christopher S. Graffeo (Mayo Clinic)H-Index: 17
Last. Ryo Nishikawa (Saitama Medical University)H-Index: 43
view all 13 authors...
Germ cell tumors (GCTs) are uncommon neoplasms predominantly arising in midline tissues. The prognostic significance of histopathology in predicting metastatic GCT behavior is poorly understood. Multicenter international cohort study including 29 patients with GCTs metastatic to brain were retrospectively investigated (18 patients from Mayo Clinic and 11 patients from the intracranial germ cell tumor genome analysis consortium in Japan). Clinical characteristics were analyzed using the Chi-squar...
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#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 15 authors...
Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment....
4 CitationsSource
#1Koichiro Yamamoto (Okayama University)H-Index: 2
#2Nayu Tamura (Okayama University)
Last. Fumio Otsuka (Okayama University)H-Index: 35
view all 8 authors...
Granulocyte colony-stimulating factor (G-CSF) is a relatively new drug that is used for recovery of chemotherapy-associated neutropenia. It is known to cause bone pain, headache and fatigue as side-effects; however, large-vessel vasculitis is extremely rare and its relation with G-CSF remains unknown. We describe a 49-year-old woman in whom arteritis developed after chemotherapy and subsequent G-CSF administration. She had experienced pinealoma 3 months ago and received surgery and chemotherapy,...
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#1Satoru Yabuno (Okayama University)H-Index: 2
#2Satoshi Kawauchi (Okayama University)H-Index: 3
Last. Shohei KohnoH-Index: 15
view all 0 authors...
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#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Yoshiko Nakano (National Cancer Research Institute)H-Index: 7
Last. Isao Date (Okayama University)H-Index: 58
view all 13 authors...
Here, we report a highly unusual case of high-grade glioneuronal tumor with a neurotrophic tropomyosin receptor kinase (NTRK) fusion gene. A 13-year-old girl presented with headache and vomiting and MRI detected two cystic lesions bilaterally in the frontal areas with surrounding edema. The left larger tumor was removed by left frontal craniotomy. The tumor was diagnosed as a high-grade glioneuronal tumor, unclassified. Methylation profiling classified it as a diffuse leptomeningeal glioneuronal...
7 CitationsSource
#1Toshihiko Shimizu (Okayama University)H-Index: 7
#2Joji Ishida (Okayama University)H-Index: 10
Last. Isao Date (Okayama University)H-Index: 58
view all 11 authors...
The combination of bevacizumab with temozolomide and radiotherapy was shown to prolong progression-free survival in newly diagnosed patients with glioblastoma, and this emphasizes the potential of bevacizumab as a glioma treatment. However, although bevacizumab effectively inhibits angiogenesis, it has also been reported to induce invasive proliferation. This study examined gene expression in glioma cells to investigate the mechanisms of bevacizumab-induced invasion. We made a human glioma U87ΔE...
6 CitationsSource
#1Yusuke Tomita (Okayama University)H-Index: 6
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 10 authors...
Background Hyponatremia generally occurs after transsphenoidal surgery (TSS) in a delayed fashion. Most patients with delayed postoperative hyponatremia (DPH) are asymptomatic or only express non-specific symptoms; consequently, DPH is associated with prolonged hospitalization. No consensus has been reached on which patients are at greatest risk of developing DPH. We reviewed patients with DPH and evaluated predictive factors for DPH.
12 CitationsSource
#1Yoshihiro Otani (Okayama University)H-Index: 7
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Background: Surgeries for deep-seated lesions are challenging because making a corridor and observing the interface between lesions and normal brain tissue are difficult. The ViewSite Brain Access System, which is a clear plastic tubular retractor system, is used for resection of deep-seated lesions. However, the tapered shape of this system may result in limitation of the surgical field and cause brain injury to observe the interface between lesions and normal tissue. In this study, we evaluate...
5 CitationsSource
#1Yoshihiro Otani (Okayama University)H-Index: 7
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 6 authors...
Background We report the case of a patient with anaplastic astrocytoma whose 2 recurrent lesions showed different imaging responses from one another after bevacizumab treatment. Histologic and genetic features of this patient are also described. Case Description A 31-year-old patient with left temporal anaplastic astrocytoma had surgery, local radiotherapy, and chemotherapy. Recurrent lesions appeared in the cerebellar vermis and left cerebellar hemisphere, and the patient was started on biweekl...
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#1Yoshihiro Otani (Okayama University)H-Index: 7
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 13 authors...
Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion
17 CitationsSource