Samikshan Dutta
University of Nebraska Medical Center
CancerInternal medicineEndocrinologyChromosome 21Polymorphism (computer science)Single-nucleotide polymorphismMolecular biologyCystathionine beta synthaseEfferocytosisAlleleChemistryProbandHaplotypeDown syndromeProstate cancerPopulationAllele frequencyMethylenetetrahydrofolate reductaseCancer researchGeneticsMedicineBiologyImmune systemCell biologyCancer cell
41Publications
12H-index
575Citations
Publications 43
Newest
#1Sanchita Rauth (NU: University of Nebraska–Lincoln)
#2Saswati Karmakar (NU: University of Nebraska–Lincoln)
Last. Moorthy P. Ponnusamy (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 34
view all 14 authors...
RNA polymerase II-associated factor 1 (PAF1)/pancreatic differentiation 2 (PD2) is a core subunit of the human PAF1 complex (PAF1C) that regulates the RNA polymerase II function during transcriptional elongation. PAF1/PD2 has also been linked to the oncogenesis of pancreatic ductal adenocarcinoma (PDAC). Here, we report that PAF1/PD2 undergoes posttranslational modification (PTM) through SUMOylation, enhancing the radiation resistance of PDAC cells. We identified that PAF1/PD2 is preferentially ...
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#1Ridwan IslamH-Index: 5
Last. Samikshan DuttaH-Index: 12
view all 9 authors...
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#1Sreyashi Bhattacharya (UNMC: University of Nebraska Medical Center)
#2Ridwan Islam (UNMC: University of Nebraska Medical Center)H-Index: 5
Last. Samikshan Dutta (UNMC: University of Nebraska Medical Center)H-Index: 12
view all 6 authors...
Background:Failure of castration resistant prostate cancer patients to Androgen Receptor Signaling Inhibitor (ARSI) poses a major challenge in terms of therapeutic development. The heterogeneous nature of prostate cancer makes it difficult to stratify the treatment modalities. A multitude of variable pathological and genetic alterations induced by systemic treatment adds further to the therapeutic complexity. Upon continued exposure to enzalutamide (ARSI), nearly 15-20% of castration resistant p...
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#1Navatha Shree Polavaram (UNMC: University of Nebraska Medical Center)H-Index: 6
#2Samikshan Dutta (UNMC: University of Nebraska Medical Center)H-Index: 12
Last. Kaustubh Datta (UNMC: University of Nebraska Medical Center)H-Index: 24
view all 15 authors...
Understanding the role of neuropilin 2 (NRP2) in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone metastasis. We observed a significant upregulation of NRP2 in prostate cancer cells metastasized to bone. Here, we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis, implicating NRP2 as a promising th...
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#1Sarah FörsterH-Index: 7
Last. Philipp ErbenH-Index: 35
view all 11 authors...
Urothelial bladder cancer ranks among the 10 most frequently diagnosed cancers worldwide. In our previous study, the transmembrane protein neuropilin-2 (NRP2) emerged as a predictive marker in patients with bladder cancer. NRP2 consists of several splice variants; the most abundant of these, NRP2a and NRP2b, are reported to have different biological functions in lung cancer progression. For other cancer types, there are no published data on the role of these transcript variants in cancer progres...
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#2Samikshan Dutta (UNMC: University of Nebraska Medical Center)H-Index: 12
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#2Samikshan DuttaH-Index: 12
Last. Kaustubh DattaH-Index: 24
view all 5 authors...
Tumor-associated macrophages (TAM) are associated with regulation of antitumor immune responses, and neuropilin-2 (NRP2), a pleiotropic receptor with an emerging role in immune responses, has recently been demonstrated to be important for this activity (Roy et al, Cancer Res. 2018). Deletion of NRP2 results in impaired clearance of apoptotic tumor cells through reduced efferocytosis, which plays a role in tumor promotion. We now show that the N-terminal domain of the histidyl-tRNA synthetase (HA...
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#1Sanchita RauthH-Index: 8
#2Saswati KarmakarH-Index: 9
Last. Moorthy P. PonnusamyH-Index: 34
view all 11 authors...
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#1Sohini Roy (UNMC: University of Nebraska Medical Center)H-Index: 7
#2Arup K. Bag (UNMC: University of Nebraska Medical Center)H-Index: 2
Last. Kaustubh Datta (UNMC: University of Nebraska Medical Center)H-Index: 24
view all 15 authors...
Tumor-associated macrophages (TAM) are causally associated with tumorigenesis as well as regulation of anti-tumor immune responses and have emerged as potential immunotherapeutic targets. Recent evidence suggests TAM phagocytose apoptotic tumor cells within the tumor microenvironment (TME) through efferocytosis in an immunologically silent manner, thus maintaining an immunosuppressed microenvironment. The signal transduction pathways coupling efferocytosis and immunosuppression are not well know...
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#1Joshua J. Souchek (UNMC: University of Nebraska Medical Center)H-Index: 16
#2Nicholas E. Wojtynek (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 5
Last. Aaron M. Mohs (UNMC: University of Nebraska Medical Center)H-Index: 22
view all 9 authors...
Abstract The presence of positive surgical margins confers an increased risk of biochemical relapse and need for salvage therapy in men undergoing radical prostatectomy. Image-guided surgery using near-infrared (NIR) fluorescent contrast agents is a potential method to detect remaining cancerous tissue. The objective of this study was to evaluate three hyaluronic acid (HA) nanoparticle (NP) formulations loaded with NIR fluorophore for their ability to contrast-enhance prostate cancer. HA was mod...
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