Antonello E. Spinelli
Vita-Salute San Raffaele University
OpticsPhysicsPathologyLuminescenceRadiationArtificial intelligencePhotonMaterials scienceMonte Carlo methodImage resolutionIn vivoPositron emission tomographyPreclinical imagingNuclear medicineSmall animalComputer scienceCancer researchMedicineCherenkov radiationRadioluminescenceBiologyOptical imaging
111Publications
21H-index
1,249Citations
Publications 111
Newest
In this short review the potential use of Cerenkov radiation and radioluminescence as internal sources for Photodynamic therapy (PDT) is discussed. PDT has been developed more than 100 years ago and is based on the induced photo conversion of a drug called photo sensitizer (PS) that trigger the production of cytotoxic reactive oxygen species (ROS) leading to the killing of the cells. In order to overcome the problem of light penetration in the tissues, different solutions were proposed in the pa...
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#1Angela Sandri (University of Verona)H-Index: 5
#2Petra Rita BassoH-Index: 4
Last. Federico Boschi (University of Verona)H-Index: 28
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Laser scalpels used in medical surgery concentrate light energy, heating the tissues. Recently, we reported thermoluminescence emission from laser-treated soft tissues. Here we investigated the thermo-optical effects caused by a laser operating at 808 nm on animal bones (beef ribs) through luminescence and fluorescence imaging, thermal imaging and scanning electron microscopy (SEM). Laser-induced artificial lesions emitted luminescence peaking around 650 nm, with a half-life of almost 1 hour. As...
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#1Paolo Rainone (University of Milano-Bicocca)H-Index: 1
#1Paolo Rainone (University of Milan)H-Index: 3
Last. Sara BelloliH-Index: 15
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Introduction The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. Functionalized silica-based nanocarriers (SiNPs) can be labeled for in vivo imaging applications and loaded with chemotherapy drugs, making possible the simultaneous noninvasive diagnosis and treatment (theranostic) for HER2-positive BC. Methods Firstly, FITC-filled SiNPs, were engineered with two different amounts...
1 CitationsSource
#2Andrea BresolinH-Index: 1
Last. Cesare CozzariniH-Index: 43
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#1Marco CatucciH-Index: 1
#2Veronica BassoH-Index: 15
Last. Anna MondinoH-Index: 29
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Background Adoptive T cell therapy (ACT) has become a promising option for cancer patients. While tumor-infiltrating lymphocytes were initially exploited as a source of tumor reactive lymphocytes, T cells genetically redirected to the tumor by TCR/CAR gene transfer are now in clinical validation. In the case of solid tumors, unfavorable immunosuppressive microenvironments remain recognized barriers to therapeutic efficacy. We have recently reported that the therapeutic activity of ACT against po...
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#1Stefania ZupponeH-Index: 3
#2Andrea BresolinH-Index: 1
Last. Cesare CozzariniH-Index: 43
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Despite the dramatic advancements in pelvic radiotherapy, urinary toxicity remains a significant side-effect. The assessment of clinico-dosimetric predictors of radiation cystitis (RC) based on clinical data has improved substantially over the last decade; however, a thorough understanding of the physiopathogenetic mechanisms underlying the onset of RC, with its variegated acute and late urinary symptoms, is still largely lacking, and data from pre-clinical research is still limited. The aim of ...
1 CitationsSource
#2Andrea BresolinH-Index: 1
Last. Cesare CozzariniH-Index: 43
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Methods for the non-invasive quantification of changes in bladder wall thickness as potential predictors of radiation cystitis in pre-clinical research would be desirable. The use of ultrasound for this aim seems promising, but is still relatively unexplored. A method using ultrasound for bladder wall thickness quantification in rats was developed and applied to measure early radiation-induced bladder wall thickness changes. Two groups (n = 9 each) of female Fischer rats were treated with a sing...
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#1Veronica TorresanH-Index: 1
#2Daniel ForrerH-Index: 12
Last. Vincenzo Amendola (UNIPD: University of Padua)H-Index: 36
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Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and to...
8 CitationsSource
Cerenkov luminescence imaging and Cerenkov photodynamic therapy have been developed in recent years to exploit the Cerenkov radiation (CR) generated by radioisotopes, frequently used in Nuclear Medicine, to diagnose and fight cancer lesions. For in vivo detection, the endpoint energy of the radioisotope and, thus, the total number of the emitted Cerenkov photons, represents a very important variable and explains why, for example, 68Ga is better than 18F. However, it was also found that the scint...
2 CitationsSource
#2Emilano D'Agostino (Philips)H-Index: 1
Last. Federico Boschi (University of Verona)H-Index: 28
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The main objective of this work was the development of a novel 2D dosimetry approach for small animal external radiotherapy using radioluminescence imaging (RLI) with a commercial complementary metal oxide semiconductor detector. Measurements of RLI were performed on the small animal image-guided platform SmART, RLI data were corrected for perspective distortion using Matlab. Four irradiation fields were tested and the planar 2D dose distributions and dose profiles were compared against dose cal...
1 CitationsSource