Joo-Won Nam
University of Illinois at Chicago
Molecular biologyCytotoxic T cellChemical structureChemistryMaterials sciencePhytochemicalTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroImmunologyAnemarrhena asphodeloidesNitric oxide synthaseLipopolysaccharideBiflavonoidDentinSelaginella doederleiniiChromatographyNitric oxideBiochemistryTraditional medicineStereochemistryMedicineProanthocyanidinCell cultureBiologyPharmacology
80Publications
20H-index
1,058Citations
Publications 77
Newest
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#2Geum Jin KimH-Index: 6
Last. Hyukjae ChoiH-Index: 25
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#2Mariana Reis (UIC: University of Illinois at Chicago)
OBJECTIVES To develop a protocol for assessment of the bulk viscoelastic behavior of dentin extracellular matrix (ECM), and to assess relationships between induced collagen cross-linking and viscoelasticity of the dentin ECM. METHODS Dentin ECM was treated with agents to induce exogenous collagen cross-linking: proanthocyanidins (PACs) from Vitis vinifera - VVe, PACs from Pinus massoniana - PMe, glutaraldehyde - (GA), or kept untreated (control). A dynamic mechanical strain sweep method was carr...
3 CitationsSource
#1Punam Thapa (Yeungnam University)H-Index: 2
#2Ye Gu (Yeungnam University)
Last. Joo-Won Nam (UIC: University of Illinois at Chicago)H-Index: 20
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Abstract Bioassay-guided fractionation of a 90% ethanol extract of Periostracum Cicadae led to the isolation of two new N-acetyldopamine dimers (1a/1b) along with six known dimers (2a/2b, 3a/3b, and 4a/4b) and two monomers (5a/5b); compounds 2a/2b, 4a/4b and 5a/5b were newly isolated from this material. All compounds were isolated as enantiomeric mixtures and each enantiomer was successfully separated by chiral-phase HPLC. The structures including absolute configurations were confirmed by high-r...
3 CitationsSource
#1Nina M. Wolf (UIC: University of Illinois at Chicago)H-Index: 4
#2Hyun Lee (UIC: University of Illinois at Chicago)H-Index: 85
Last. Celerino Abad-Zapatero (UIC: University of Illinois at Chicago)H-Index: 5
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The biological processes related to protein homeostasis in Mycobacterium tuberculosis, the etiologic agent of tuberculosis, have recently been established as critical pathways for therapeutic intervention. Proteins of particular interest are ClpC1 and the ClpC1–ClpP1–ClpP2 proteasome complex. The structure of the potent antituberculosis macrocyclic depsipeptide ecumicin complexed with the N-terminal domain of ClpC1 (ClpC1-NTD) is presented here. Crystals of the ClpC1-NTD–ecumicin complex were mo...
4 CitationsSource
#1Nina M. WolfH-Index: 4
#2Hyun LeeH-Index: 85
Last. Celerino Abad-ZapateroH-Index: 5
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#1Sang-Hyun Song (SNU: Seoul National University)H-Index: 15
#2Mi Seong Jeon (SNU: Seoul National University)H-Index: 3
Last. Tae Yong Kim (SNU: Seoul National University)H-Index: 9
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Six GATA transcription factors play important roles in eukaryotic development. Among these, GATA2, an essential factor for the hematopoietic cell lineage, exhibits low expression in human gastric tissues, whereas GATA6, which is crucial for gastrointestinal development and differentiation, is frequently amplified and/or overexpressed in human gastric cancer. Interestingly, we found that GATA6 was overexpressed in human gastric cancer cells only when GATA2 expression was completely absent, thereb...
13 CitationsSource
#1RS Phansalkar (UIC: University of Illinois at Chicago)H-Index: 11
#2Joo-Won Nam (UIC: University of Illinois at Chicago)H-Index: 20
Last. Guido F. Pauli (UIC: University of Illinois at Chicago)H-Index: 61
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Abstract Proanthocyanidins (PACs) find wide applications for human use including food, cosmetics, dietary supplements, and pharmaceuticals. The chemical complexity associated with PACs has triggered the development of various chromatographic techniques, with countercurrent separation (CCS) gaining in popularity. This study applied the recently developed DESIGNER (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources) approach for the selective enrichment of trime...
18 CitationsSource
#1Daniel Kulakowski (UIC: University of Illinois at Chicago)H-Index: 2
#2A.A. Leme-Kraus (UIC: University of Illinois at Chicago)H-Index: 8
Last. Anakarina B. Bedran-Russo (UIC: University of Illinois at Chicago)H-Index: 20
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Abstract Proanthocyanidins (PACs) are plant-derived, multifunctional compounds that possess high interactivity with extracellular matrix (ECM) components. The documented affinity of PACs for type-I collagen is directly correlated with their structural features and degree of polymerization. In this investigation, centrifugal partition chromatography (CPC) was used to sequentially deplete less active monomeric and polymeric PACs from a crude Pinus massoniana bark extract to create refined mixtures...
12 CitationsSource
#1A.A. Leme-Kraus (UIC: University of Illinois at Chicago)H-Index: 8
#2Berdan Aydin (UIC: University of Illinois at Chicago)H-Index: 10
Last. Anakarina B. Bedran-Russo (UIC: University of Illinois at Chicago)H-Index: 20
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Oligomeric proanthocyanidins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standardized mixtures for biological applications. Herein, we found that multiscale interactions of OPACs with the dentin matrix create tight biointerfaces with hydrophobic methacrylate adhesives on wet surfaces. An enriched mixture of OPACs, with a known phytochemical profile, was produced from grape seed crude extract (Vitis vinifera; enriched grape seed extract [e-GSE]) and ...
30 CitationsSource