Min-Tzu Lo
University of California, San Diego
GeneGenome-wide association studyInternal medicineSample size determinationSNPSingle-nucleotide polymorphismHeritabilityPhysical therapyGenetic associationOsteoarthritisSteatosisNonalcoholic fatty liver diseaseDiseaseFibrosisLinkage disequilibriumGeneticsGenetic heterogeneityComputational biologyMedicineCohortEvolutionary biologyBiologyGastroenterology
28Publications
14H-index
662Citations
Publications 26
Newest
Sex differences have been observed in the clinical manifestations of Alzheimer's disease (AD) and elucidating their genetic basis is an active research topic. Based on autosomal genotype data of 7,216 men and 10,680 women, including 8,136 AD cases and 9,760 controls, we explored sex-related genetic heterogeneity in AD by investigating SNP heritability, genetic correlation, as well as SNP- and gene-based genome-wide analyses. We found similar SNP heritability (men: 19.5%; women: 21.5%) and high g...
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#1Min-Tzu Lo (UCSD: University of California, San Diego)H-Index: 14
#2Karolina Kauppi (UCSD: University of California, San Diego)H-Index: 17
Last. Chi-Hua Chen (UCSD: University of California, San Diego)H-Index: 34
view all 10 authors...
Abstract The risk of APOE for Alzheimer's disease (AD) is modified by age. Beyond APOE, the polygenic architecture may also be heterogeneous across age. We aim to investigate age-related genetic heterogeneity of AD and identify genomic loci with differential effects across age. Stratified gene-based genome-wide association studies and polygenic variation analyses were performed in the younger (60–79 years, N = 14,895) and older (≥80 years, N = 6559) age-at-onset groups using Alzheimer's Disease ...
11 CitationsSource
#1Cyrielle Caussy (UCSD: University of California, San Diego)H-Index: 17
#2Meera Bhargava (UCSD: University of California, San Diego)H-Index: 2
Last. Rohit Loomba (UCSD: University of California, San Diego)H-Index: 91
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Author(s): Caussy, Cyrielle; Bhargava, Meera; Villesen, Ida F; Gudmann, Natasja S; Leeming, Diana J; Karsdal, Morten A; Faulkner, Claire; Bao, Denny; Liu, Amy; Lo, Min-Tzu; Bettencourt, Ricki; Bassirian, Shirin; Richards, Lisa; Brenner, David A; Chen, Chi-Hua; Sirlin, Claude B; Loomba, Rohit | Abstract: BACKGROUND:PRO-C3 (N-terminal pro-peptide of type III collagen) is a biomarker of liver fibrosis in nonalcoholic-fatty-liver-disease (NAFLD). This study examines the association between PRO-C3 co...
12 CitationsSource
#1Nilotpal Sanyal (UCSD: University of California, San Diego)H-Index: 6
#2Min-Tzu Lo (UCSD: University of California, San Diego)H-Index: 14
Last. Chi-Hua Chen (UCSD: University of California, San Diego)H-Index: 34
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Motivation: Multiple marker analysis of the genome-wide association study (GWAS) data has gained ample attention in recent years. However, because of the ultra high-dimensionality of GWAS data, suc ...
12 CitationsSource
#1Cyrielle Caussy (University of Lyon)H-Index: 17
#2Cynthia HsuH-Index: 7
Last. Rohit Loomba (UCSD: University of California, San Diego)H-Index: 91
view all 16 authors...
Author(s): Caussy, C; Hsu, C; Lo, MT; Liu, A; Bettencourt, R; Ajmera, VH; Bassirian, S; Hooker, J; Sy, E; Richards, L; Schork, N; Schnabl, B; Brenner, DA; Sirlin, CB; Chen, CH; Loomba, R | Abstract: © 2018 by the American Association for the Study of Liver Diseases. Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease (NAFLD). We aimed to examine if serum metabolites, especially those derived from the gut-microbiome, have a shared gene-effect with h...
65 CitationsSource
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2Olav B. Smeland (Oslo University Hospital)H-Index: 22
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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Author(s): Fan, CC; Smeland, OB; Schork, AJ; Chen, CH; Holland, D; Lo, MT; Sundar, VS; Frei, O; Jernigan, TL; Andreassen, OA; Dale, AM | Abstract: © The Author(s) 2018. Published by Oxford University Press. All rights reserved. Structural neuroimaging measures based on magnetic resonance imaging have been at the forefront of imaging genetics. Global efforts to ensure homogeneity of measurements across study sites have enabled large-scale imaging genetic projects, accumulating nearly 50K samples ...
8 CitationsSource
#1Karolina KauppiH-Index: 17
#2Sara Brin RosenthalH-Index: 15
Last. Chi-Hua ChenH-Index: 34
view all 9 authors...
Objective:Antipsychotic drugs were incidentally discovered in the 1950s, but their mechanisms of action are still not understood. Better understanding of schizophrenia pathogenesis could shed light on actions of current drugs and reveal novel “druggable” pathways for unmet therapeutic needs. Recent genome-wide association studies offer unprecedented opportunities to characterize disease gene networks and uncover drug-disease relationships. Polygenic overlap between schizophrenia risk genes and a...
7 CitationsSource
#1Chi-Hua Chen (UCSD: University of California, San Diego)H-Index: 34
#2Yunpeng Wang (UCSD: University of California, San Diego)H-Index: 34
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
view all 15 authors...
Author(s): Chen, CH; Wang, Y; Lo, MT; Schork, A; Fan, CC; Holland, D; Kauppi, K; Smeland, OB; Djurovic, S; Sanyal, N; Hibar, DP; Thompson, PM; Thompson, WK; Andreassen, OA; Dale, AM | Abstract: © 2017 The Author(s). Discovering genetic variants associated with human brain structures is an on-going effort. The ENIGMA consortium conducted genome-wide association studies (GWAS) with standard multi-study analytical methodology and identified several significant single nucleotide polymorphisms (SNPs)...
10 CitationsSource
#1Min-Tzu Lo (UCSD: University of California, San Diego)H-Index: 14
#2Yunpeng Wang (UCSD: University of California, San Diego)H-Index: 34
Last. Chi-Hua Chen (UCSD: University of California, San Diego)H-Index: 34
view all 13 authors...
Author(s): Lo, MT; Wang, Y; Kauppi, K; Sanyal, N; Fan, CC; Smeland, OB; Schork, A; Holland, D; Hinds, DA; Tung, JY; Andreassen, OA; Dale, AM; Chen, CH | Abstract: © The Author 2017. Published by Oxford University Press. All rights reserved. Neuroticismreflects emotional instability, and is related to various mental and physical health issues. However, the majority of genetic variants associated with neuroticism remain unclear. Inconsistent genetic variants identified by different genomewide asso...
4 CitationsSource
#1Olav B. Smeland (Oslo University Hospital)H-Index: 22
#2Yunpeng Wang (UCSD: University of California, San Diego)H-Index: 34
Last. Ole A. Andreassen (Oslo University Hospital)H-Index: 123
view all 13 authors...
Schizophrenia is associated with differences in personality traits, and recent studies suggest that personality traits and schizophrenia share a genetic basis. Here we aimed to identify specific genetic loci shared between schizophrenia and the Big Five personality traits using a Bayesian statistical framework. Using summary statistics from genome-wide association studies (GWAS) on personality traits in the 23andMe cohort (n = 59,225) and schizophrenia in the Psychiatric Genomics Consortium coho...
48 CitationsSource