Yuan Guan
Jilin University
Internal medicineMicrosomal triglyceride transfer proteinEndocrinologyKinaseChemistryOxidative stressAMP-activated protein kinaseOsteoblastFatty liverLipid oxidationJanus kinase 2LDL receptorLipid metabolismFatty acid synthaseFatty acidBiochemistryApolipoprotein EMetabolismSignal transductionApolipoprotein BVery low-density lipoproteinBiologyCell biologyProtein kinase A
12Publications
8H-index
245Citations
Publications 12
Newest
#1Jihong Dong (JLU: Jilin University)H-Index: 6
#2Gerd Bobe (Linus Pauling Institute)H-Index: 28
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
view all 10 authors...
ABSTRACT Inflammation is critical in the progression from benign hepatic lipidosis to pathological hepatic steatosis. The objective of this study was to examine the potential role of the outer mitochondrial membrane protein mitofusin 2 (MFN2) in the etiology of hepatic steatosis in dairy cows during early lactation. Using a nested case–control design, we compared blood and liver samples from 10 healthy cows and 10 age-matched cows with moderate fatty liver. Cows with moderate fatty liver had hig...
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#1Xin Shu (JLU: Jilin University)H-Index: 5
#2Zhiyuan Fang (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
view all 12 authors...
Ketosis is a metabolic disease of dairy cows often characterized by high concentrations of ketone bodies and fatty acids, but low milk protein and milk production. The Janus kinase 2 (JAK2)-signal transducer and activator of transcription 5 (STAT5) and the mechanistic target of rapamycin (mTOR) signaling pathways are central for the regulation of milk protein synthesis. The effect of high levels of fatty acids on these pathways and beta-casein synthesis are unknown in dairy cows with clinical ke...
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#1Yiwei Zhu (JLU: Jilin University)H-Index: 9
#2Yuan Guan (JLU: Jilin University)H-Index: 8
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
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ABSTRACT Disruption of endoplasmic reticulum (ER) homeostasis, often termed ER stress, is intrinsically linked with perturbation of lipid metabolism in humans and mice. Whether ER homeostasis is affected in cows experiencing fatty liver is unknown. The aim of this study was to investigate the potential role of ER stress in hepatic lipid accumulation in calf hepatocytes and ER stress status in dairy cows with severe fatty liver. In vitro experiments were conducted in which hepatocytes were isolat...
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#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 34
view all 9 authors...
Background Subacute ruminal acidosis (SARA) is a metabolic disease in high-producing dairy cattle, and is accompanied by rumenitis. However, the mechanism of rumenitis remains unclear. Therefore, the aim of this study was to investigate the molecular mechanism of rumenitis in dairy cows with SARA.
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#1Xiliang Du (JLU: Jilin University)H-Index: 15
#2Yiwei Zhu (JLU: Jilin University)H-Index: 9
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 14 authors...
ABSTRACT The hepatic growth hormone (GH)–insulin-like growth factor (IGF)-I axis is essential for regulating intrahepatic lipid metabolism. Ketotic cows are characterized by high blood concentrations of fatty acids and β-hydroxybutyrate (BHB), which display lipotoxicity. The aim of this study was to investigate changes in the hepatic GH–IGF-I axis in ketotic cows and to determine the effects of fatty acids and BHB on the GH–IGF-I axis in calf hepatocytes. Liver and blood samples were collected f...
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#1Xinwei Li (JLU: Jilin University)H-Index: 34
#2Yuan Guan (JLU: Jilin University)H-Index: 8
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 9 authors...
Abstract Fatty liver is a major metabolic disorder of dairy cows. One important reason is that hepatic very low-density lipoproteins (VLDL) assembly was significant decreased in dairy cows with fatty liver. In addition, the impairment of insulin-like growth factor (IGF)-1 synthesis was involved in the development of fatty liver. Therefore, the objective of this study was to investigate the effects of IGF-1 on the VLDL assembly in cow hepatocytes. In this study, cow hepatocytes were cultured and ...
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#8Liancheng Lei (JLU: Jilin University)H-Index: 22
Abstract High serum concentrations of nonesterified fatty acids (NEFA), which may affect the synthesis and assembly of very low density lipoproteins (VLDL), are associated with fatty liver during the early lactation period. Therefore, the objective of this study was to investigate the effects of NEFA on the synthesis and assembly of VLDL in bovine hepatocytes. Bovine hepatocytes were cultured and treated with different concentrations of NEFA. The mRNA expression of apolipoprotein B100 ( ApoB100 ...
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#5Liancheng Lei (JLU: Jilin University)H-Index: 22
The effect of acetic acid on hepatic lipid metabolism in ruminants differs significantly from that in monogastric animals. Therefore, the aim of this study was to investigate the regulation mechanism of acetic acid on the hepatic lipid metabolism in dairy cows. The AMP-activated protein kinase (AMPK) signaling pathway plays a key role in regulating hepatic lipid metabolism. In vitro, bovine hepatocytes were cultured and treated with different concentrations of sodium acetate (neutralized acetic ...
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#1Xinwei Li (JLU: Jilin University)H-Index: 34
#2Yuan Guan (JLU: Jilin University)H-Index: 8
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 8 authors...
Zinc deficiency impairs the hepatic lipid metabolism. Previous studies were focused on the negative effects of zinc deficiency on the hepatic lipid metabolism. A few studies investigated the effects of high zinc levels on the lipid metabolism in hepatocytes. In this study, rat hepatocytes were cultured and treated with different and high concentrations of zinc to investigate the effects of high zinc levels on the lipid synthesis in hepatocytes in vitro. The levels of hepatocytes functional marke...
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Non-esterified fatty acids (NEFAs) act as signaling molecules involved in regulating genes expression to modulate lipid metabolism. However, the regulation mechanism of NEFAs on lipid metabolism in dairy cows is unclear. The AMP-activated protein kinase (AMPK) signaling pathway plays a key role in regulating hepatic lipid metabolism. In vitro, bovine hepatocytes were cultured and treated with different concentrations of NEFAs and AMPKα inhibitors (BML-275). NEFAs increased AMPKα phosphorylation ...
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