Tao Feng
Motion estimationImaging phantomSignalAlgorithmPhysicsBiomedical engineeringIterative reconstructionArtificial intelligenceAttenuationProjection (set theory)GatingPositron emission tomographyCardiac PETNuclear medicineComputer visionMathematicsImage noiseComputer scienceImage qualityMedicine
Publications 58
Parametric imaging of Ki (the net influx rate) in FDG PET has been shown to provide better quantification and improved specificity for cancer detection compared with SUV imaging. Current methods for generating parametric images usually requires a long dynamic scan time. With the recently developed uEXPLORER scanner, a dramatic increase of sensitivity has reduced the noise in dynamic imaging, making it more robust to employ a non-linear estimation method and flexible protocols. In this work, we e...
#1Tao FengH-Index: 7
#2Shulin YaoH-Index: 4
Last. Baixuan XuH-Index: 6
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Conventional PET image reconstruction is achieved by the statistical iterative method. Deep learning provides another opportunity for speeding up the image reconstruction process. However, conventional deep learning-based image reconstruction requires a fully connected network for learning the Radon transform. The use of fully connected networks greatly complicated the network and increased hardware cost. In this study, we proposed a novel deep learning-based image reconstruction method by utili...
#7P.M. Price (ICL: Imperial College London)H-Index: 60
#10Terry Jones (UC Davis: University of California, Davis)H-Index: 90
Parametric imaging has been shown to provide better quantitation physiologically compared with SUV imaging in PET. With the increased sensitivity from a recently developed total-body PET scanner, whole-body scans with higher temporal resolution become possible for dynamic analysis and parametric imaging. In this paper, we focus on deriving the parameter k1 using compartmental modeling, and on developing a method to acquire whole-body FDG-PET parametric images using only the first 90 seconds of t...
#3Yaping WuH-Index: 3
#4Tao FengH-Index: 7
Last. Zhun Huang (Zhengzhou University)
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128 null Introduction: null null The world’s first 2-meter-long total-body PET scanner (uEXPLORER) provides a versatile platform for biomedical research and opens a new venue for lesion detection throughout the body. Our study aims to explore the value of multi-parametric total-body dynamic PET/CT imaging in distinguishing benign and malignant lymph nodes of the whole body. Materials and Methods: A total number of 40 patients with lymph node lesions were recruited in this study, including 25 mal...
#1Shulin Yao (Chinese PLA General Hospital)H-Index: 4
#2Tao Feng (BP)H-Index: 7
Last. Baixuan Xu (Chinese PLA General Hospital)H-Index: 6
view all 8 authors...
PURPOSE: Parametric imaging using the Patlak model has been shown to provide improved lesion detectability and specificity. The Patlak model requires both tissue time-activity-curves (TACs) after equilibrium and knowledge of the input function from the start of injection. Therefore, the conventional dynamic scanning protocol typically starts from the radiotracer injection all the way to equilibrium. In this paper, we propose the use of hybrid population-based and model-based input function estim...
#1Tao Feng (BP)H-Index: 7
#2Gang YangH-Index: 1
Last. Yun DongH-Index: 7
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1420 Introduction: Respiratory motion introduces motion blurring and attenuation and activity mismatch artifacts in PET/CT scans. In a free-breathing PET/CT scan, the data-driven approach allows the acquisition of respiratory information and subsequent motion compensation in the PET images. The 3D CT image is usually scanned prior to the PET scan, and the CT image is also affected by respiratory motion. Different axial positions in the CT image may be in different respiratory phases due to the h...
#1Nan Meng (Zhengzhou University)H-Index: 3
#2Fangfang Fu (Zhengzhou University)H-Index: 4
Last. Tianyi Xu
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1699 null Introduction: null null Lung cancer remains the cause of the highest morbidity and the main cause of cancer-related mortality worldwide. The EXPLORER consortium has developed the world’s first 2-meter long total-body PET scanner (uEXPLORER) to provide a versatile platform for biomedical research and clinical applications. This work aims to determine if the kinetic analysis of total-body 18F-FDG PET/CT would be useful in differentiating benign and malignant pulmonary lesions. null Metho...
#1Richard E. Carson (Yale University)H-Index: 96
#2Eric Berg (UC Davis: University of California, Davis)H-Index: 15
Last. Praveen Honhar (Yale University)H-Index: 1
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1120 null Objectives: null null PET human brain imaging has evolved dramatically, with the availability of a vast array of specific radiotracers, leading to numerous imaging paradigms to measure a wide range of brain targets and to assess neurotransmitter and receptor dynamics. Brain-dedicated PET systems could offer important advantages over currently available whole-body PET systems in terms of sensitivity and resolution. However, state-of-the-art for dedicated brain PET has not progressed bey...
#1Tao Feng (BP)H-Index: 7
#2Gang YangH-Index: 1
Last. Yun DongH-Index: 7
view all 0 authors...
A dedicated reconstruction algorithm, usually 4D image reconstruction, is usually required for respiratory motion compensation. The use of a dedicated reconstruction method may make it harder for implementation and can be time-consuming especially with the use of 4D reconstruction. In this study, we present a motion compensation approach that directly applied to Listmode or sinogram data. Using the proposed approach, a regular reconstruction method with minimal or no modifications can be applied...
#1Tao Feng (BP)H-Index: 7
#2Gang YangH-Index: 1
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 0 authors...
The conventional gating approach creates a dilemma for systems with large field-of-view (FOV) such as the uExplorer system. The motion effect is localized with variable motion amplitude across the whole FOV. A conventional gating approach would increase the noise for regions without motion, or with small motion amplitude. Existing local gating approach that allows optimized locally adaptive gating numbers requires a 4D reconstruction, which is time-consuming for generating of a 3D image. Image-d...
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