Subramaniam Pennathur
University of Michigan
Internal medicineEndocrinologyChemistryImmunologyMyeloperoxidaseMetabolomicsOxidative stressInflammationType 2 diabetesCholesterolKidney diseaseDiseaseLipoproteinKidneyHypochlorous acidBiochemistryDiabetes mellitusMedicineBiologyCell biology
182Publications
45H-index
5,230Citations
Publications 181
Newest
#1Jonathan B Thacker (UM: University of Michigan)
#1Jonathan B. Thacker (UM: University of Michigan)
Last. Subramaniam Pennathur (UM: University of Michigan)H-Index: 45
view all 3 authors...
γ-Glutamylpeptides have been identified as potential biomarkers for a number of diseases including cancer, diabetes, and liver disease. In this study, we developed and validated a novel quantitative analytical strategy for measuring γ-glutamylisoleucine, γ-glutamylthreonine, and γ-glutamylvaline, all of which have been previously reported as potential biomarkers for prostate cancer, in HeLa cells using UHPLC-MS/MS. A BEH C18 column was used as the stationary phase. Mobile phase A was 99:1 water:...
Source
#1Stephanie Eid (UM: University of Michigan)H-Index: 9
#2Lucy M. Hinder (UM: University of Michigan)H-Index: 16
Last. Frank C. Brosius (UM: University of Michigan)H-Index: 60
view all 17 authors...
Diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN) are two common diabetic complications. However, their pathogenesis remains elusive and current therapies are only modestly effective. We evaluated genome-wide expression to identify pathways involved in DKD and DPN progression in db/db eNOS-/- mice receiving renin-angiotensin-aldosterone system (RAS)-blocking drugs to mimic the current standard of care for DKD patients. Diabetes and eNOS deletion worsened DKD, which improved ...
Source
#1Max T. Aung (UM: University of Michigan)H-Index: 7
#2Youfei Yu (UM: University of Michigan)H-Index: 5
Last. John D. MeekerH-Index: 75
view all 9 authors...
BACKGROUND Humans are exposed to mixtures of toxicants that can impact several biological pathways. We investigated the associations between multiple classes of toxicants and an extensive panel of biomarkers indicative of lipid metabolism, inflammation, oxidative stress, and angiogenesis. METHODS We conducted a cross-sectional study of 173 participants (median 26 wk gestation) from the LIFECODES birth cohort. We measured exposure analytes of multiple toxicant classes [metals, phthalates, phenols...
Source
#1Stephanie Eid (UM: University of Michigan)H-Index: 9
#2Phillipe D. O'Brien (UM: University of Michigan)H-Index: 11
Last. Subramaniam Pennathur (UM: University of Michigan)H-Index: 45
view all 12 authors...
Diabetes is a global healthcare problem associated with enormous healthcare and personal costs. Despite glucose lowering agents that control glycaemia, both type 1 (T1D) and type (T2D) diabetes patients often develop microvascular complications that increase morbidity and mortality. Current interventions rely on careful glycemic control and healthy lifestyle choices, but these are ineffective at reversing or completely preventing the major microvascular complications, diabetic peripheral neuropa...
Source
#1Matthew A. Sparks (Duke University)H-Index: 30
#2Fitra Rianto (Duke University)H-Index: 1
Last. Thomas M. Coffman (NUS: National University of Singapore)H-Index: 86
view all 14 authors...
Activation of AT1 (type 1 Ang) receptors stimulates cardiomyocyte hypertrophy in vitro. Accordingly, it has been suggested that regression of cardiac hypertrophy associated with renin-Ang system blockade is due to inhibition of cellular actions of Ang II in the heart, above and beyond their effects to reduce pressure overload. We generated 2 distinct mouse lines with cell-specific deletion of AT1A receptors, from cardiomyocytes. In the first line (C-SMKO), elimination of AT1A receptors was achie...
1 CitationsSource
#1Anna V. Mathew (UM: University of Michigan)H-Index: 18
#2Lixia Zeng (UM: University of Michigan)H-Index: 13
Last. Subramaniam Pennathur (UM: University of Michigan)H-Index: 45
view all 8 authors...
Increased myeloperoxidase (MPO) expression and activity are associated with atherosclerotic disease in patients with chronic kidney disease (CKD). However, the causal relationship between MPO and the development and progression of atherosclerosis in patients with CKD is unknown. Eight-week-old male low-density-lipoprotein-receptor-deficient mice were subjected to 5/6 nephrectomy, irradiated, and transplanted with bone marrow from MPO-deficient mice to induce bone marrow MPO deletion (CKD-bMPOKO)...
1 CitationsSource
#1Jennifer L. Bragg-Gresham (UM: University of Michigan)H-Index: 59
#2Jarnail Singh Thakur (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 26
Last. Rajiv SaranH-Index: 61
view all 8 authors...
OBJECTIVES India is witnessing a disturbing growth in non-communicable diseases (NCDs), including chronic kidney disease (CKD). Recently, a WHO STEPS survey was conducted in the state of Punjab, India to collect data from the adult population on NCD risk factors. We sought to compare the prevalence of CKD and its risk factors between this large state in northern India and the USA. SETTING Samples were drawn from both locations, Punjab, India and the USA, using multistage stratified sampling desi...
Source
#1Oren Rom (UM: University of Michigan)H-Index: 16
#2Yuhao Liu (UM: University of Michigan)H-Index: 4
Last. Y. Eugene Chen (UM: University of Michigan)H-Index: 59
view all 33 authors...
Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has reached epidemic proportions with no pharmacological therapy approved. Lower circulating glycine is consistently reported in patients with NAFLD, but the causes for reduced glycine, its role as a causative factor, and its therapeutic potential remain unclear. We performed transcriptomics in livers from humans and mice with NAFLD and found suppression of glycine biosynthetic genes, primarily alanine-glyoxyl...
5 CitationsSource
#1Max T. Aung (UM: University of Michigan)H-Index: 7
#2Yanyi Song (UM: University of Michigan)H-Index: 3
Last. Bhramar Mukherjee (UM: University of Michigan)H-Index: 58
view all 9 authors...
Diverse toxicological mechanisms may mediate the impact of environmental toxicants (phthalates, phenols, polycyclic aromatic hydrocarbons, and metals) on pregnancy outcomes. In this study, we introduce an analytical framework for multivariate mediation analysis to identify mediation pathways (q = 61 mediators) in the relationship between environmental toxicants (p = 38 analytes) and gestational age at delivery. Our analytical framework includes: (1) conducting pairwise mediation for unique expos...
1 CitationsSource
Source