Mariangela Corsi
Artois University
Internal medicineEndocrinologyLRP1SurgeryPathologyProinflammatory cytokineReceptorChemistryImmunologyAutismNeuroprotectionPlatelet lysateMacrophage polarizationInflammationHyaluronic acidInfiltration (medical)Blood–brain barrierAutism spectrum disorderKetogenic dietDiseaseWound healingKetone bodiesBioinformaticsInterleukin 18MedicineBiologyNeuroinflammationNeuropeptide Y receptorCell biologyPharmacology
Publications 19
Alzheimer’s disease (AD) is characterized by the abnormal accumulation of amyloid-β (Aβ) peptides in the brain. The pathological process has not yet been clarified, although dysfunctional transport of Aβ across the blood–brain barrier (BBB) appears to be integral to disease development. At present, no effective therapeutic treatment against AD exists, and the adoption of a ketogenic diet (KD) or ketone body (KB) supplements have been investigated as potential new therapeutic approaches. Despite ...
7 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#1Rita Businaro (Sapienza University of Rome)H-Index: 6
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
view all 14 authors...
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets, which are source of clinical hemoderivates, such as platelet lysate (PL), routinely employed in several clinical applications as wound healing, and to preserve ex vivo the progenitor properties of the adipose stromal cells pool. So far, the pres...
8 CitationsSource
#1Alessandro Pinto (Sapienza University of Rome)H-Index: 16
#2Alessio Bonucci (Sapienza University of Rome)H-Index: 1
Last. Rita Businaro (Sapienza University of Rome)H-Index: 18
view all 5 authors...
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease. The main activity of the ketogenic diet has been related to improved mitochondrial function and decreased oxidative stress. B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular e...
49 CitationsSource
#1Raffaele CapoanoH-Index: 13
#2Rita Businaro (Sapienza University of Rome)H-Index: 18
Last. Serafino RicciH-Index: 16
view all 12 authors...
OBJECTIVE: Treatment of wounds difficult to heal concerns 50% of the elderly population in Italy and is therefore an extreme relevance social burden. The present study shows how the treatment with autologous leuco-platelets reduces the healing time of wounds improving the functional recovery. PATIENTS AND METHODS: One hundred patients with ulcers of the legs were divided in two groups: 1) 50 patients treated with conventional therapies; 2) 50 patients treated with autologous leuco-platelet conce...
4 CitationsSource
#1Andrzej MałeckiH-Index: 1
#2Janina Skipor-Lahuta (PAN: Polish Academy of Sciences)H-Index: 1
Last. András Dér (MTA: Hungarian Academy of Sciences)H-Index: 23
view all 299 authors...
11 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 6
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
Last. Alessandro Pinto (Sapienza University of Rome)H-Index: 16
view all 8 authors...
BACKGROUND: Most of the recent reports suggest that inflammatory mediators play a central role in the etiopathogenesis of Alzheimer's disease (AD) and that the conditions leading to a chronic low-grade inflammation, such as stress, depression, obesity and metabolic syndrome, increase the odds of developing Mild Cognitive Impairment (MCI) and AD. Microglia cells are the main actors in the AD process: stimuli from the microenvironment may induce microglia cells to switch to a classically activated...
21 CitationsSource
#1Rita BusinaroH-Index: 18
#2Ilia J. ElenkovH-Index: 30
Last. Rachele RiganòH-Index: 31
view all 10 authors...
#1Mariangela CorsiH-Index: 7
#2T Di RaimoH-Index: 1
Last. Max Rapp-Ricciardi (University of Gothenburg)H-Index: 4
view all 7 authors...
: Cognitive disability linked to neurodegenerative diseases and in particular to Alzheimer's disease, remains an increasing cause for concern through a dramatic prevalence increment and associated socio-economic burdens. Initially Alzheimer's disease develops asymptomatically with primary clinical signs, such as memory impairment, decline of spatial and perceptual abilities, occurring at a later stage. This delay implies the possibility of promoting early interventions during the pre-symptomatic...
4 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#2Mariangela Corsi (Sapienza University of Rome)H-Index: 7
Last. Elena De Falco (Sapienza University of Rome)H-Index: 20
view all 11 authors...
New civil wars and waves of terrorism are causing crucial social changes, with consequences in all fields, including health care. In particular, skin injuries are evolving as an epidemic issue. From a physiological standpoint, although wound repair takes place more rapidly in the skin than in other tissues, it is still a complex organ to reconstruct. Genetic and clinical variables, such as diabetes, smoking, and inflammatory/immunological pathologies, are also important risk factors limiting the...
8 CitationsSource
#1Rita Businaro (Sapienza University of Rome)H-Index: 18
#2Mariangela Corsi (Sapienza University of Rome)H-Index: 7
Last. Serafino Ricci (Sapienza University of Rome)H-Index: 16
view all 11 authors...
Background Autism spectrum disorder (ASD) is a neurodevelopmental disease which affects 1 in 88 children. Its etiology remains basically unknown, but it is apparent that neuroinflammation is involved in disease development. Great attention has been focused on pro-inflammatory cytokines, and several studies have reported their dysfunction unbalance in serum as well as in the brain. The present work aimed at evaluating putative dysregulation of interleukin-18 (IL-18), a pro-inflammatory cytokine o...
15 CitationsSource